The Bothrops legacy: Vasoactive peptides from Brazil

Greene LJ , Camargo AC , Krieger EM , Stewart JM , Ferreira SH Inhibition of the conversion of angiotensin I to II and potentiation of bradykinin by small peptides present in Bothrops jararaca venom. Circ Res 1972;31 (suppl 2):62-71.

Nguyen G. , Delarue F. , Burcklé C. , Bouzhir L. , Giller T. , Sraer JD Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002;109:1417-27.

Ludwig J. , Kerscher S. , Brandt U. et al. Identification and characterisation of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules . J Biol Chem 1998;273:10939-47.

Schefe JH , Menk M. , Reinemund J. et al. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res 2006;99:1355-66.

Ichihara A. , Suzuki F. , Nakagawa T. et al. Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice. J Am Soc Nephrol 2006;17:1950-61.

Feldt S. , Maschke U. , Dechend R. , Luft FC , Muller DN The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling . J Am Soc Nephrol 2008;[Epub ahead of print]

Muller DN , Klanke B. , Feldt S. et al. (Pro)renin receptor peptide inhibitor `handle-region` peptide does not affect hypertensive nephrosclerosis in Goldblatt rats. Hypertens 2008;51:676-81.

Feldt S. , Batenburg WW , Mazak I. et al. Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertens 2008;22:[Epub ahead of print]

Batenburg WW , Krop M. , Garrelds IM et al. Prorenin is the endogenous agonist of the (pro)renin receptor. Bindings kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor . J Hypertens 2007;25:2441-53.

Robertson AL Jr , Khairallah PA Angiotenisn II: rapid localization in nuclei of smooth and cardiac muscle. Science 1971 ;172:1138-9.

Kumar R. , Singh VP , Bake KM The intracellular reninangiotensin system: implications in cardiovascular angiotensin system: implications in cardiovascular remodeling. Curr Opin Nephrol Hypertens 2008;17:168-73.

Haller H. , Lindschau C. , Erdmann B. , Quass P. , Luft FC Effects of intracellular angiotensin II in vascular smooth muscle cells. Circ Res 1996;79:765-72.

Lambert DW , Hooper NM , Turner AJ Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system. Biochem Pharmacol 2008;75:781-6.

Raizada MK , Ferreira AJ ACE 2: a new target for cardiovascular disease therapuetics. J Cardiovasc Pharmacol 2007;50:112-19.

Feng Y. , Yue X. , Xia H. et al. Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor down-regulation. Circ Res 2008;[Epub ahead of print]

Wu P. , Costa-Gonalves AC , Todiras M. et al. Endothelial dysfunction and elevated blood pressure in MAS gene-deleted mice. Hypertension 2008;51:574-80.

van der Wouden EA , Ochodnick P. , van Dokkum RP et al. The role of angiotensin(1-7) in renal vasculature of the rat. J Hypertens 2006;24:1971-8.

Nagata S. , Kato J. , Sasaki K. , Minomino N. , Eto T. , Kitamura K. Isolation and identification of proangiotensin-1-12, a possible component of the renin-angiotensin system. Biochem Biophy Res Commun 2006;350:1026-31.

Sharma U. , Rhaleb NE , Pokharel S. et al. Novel antiinflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage. Am J Physiol Heart Circ Physiol 2008;[Epub ahead of print].

Lu H. , Rateri DL , Feldman DL et al. Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. J Clin Invest 2008;[Epub ahead of print].

Kobori H. , Nangaku M. , Navar LG , Nishiyama A. The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev 2007;59:251-87.

Souza PP , Fukada SY , Cunha FQ , Costa CA , Costa-Neto CM Regulation of angiotensin II receptors levels during rat induced pulpitis . Regul Pept 2007;140(1-2):27-31.

Padia SH , Kemp BA , Howell NL , Fournie-Zaluski MC , Roques BP , Carey RM Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats. Hypertens 2008;51:460-5.

Ceravolo GS , Fernandes L. , Munhoz CD et al. Angiotensin II chronic infusion induces B1 receptor expression in aorta of rats. Hypertens 2007;50:756-61.

Gassanov N. , Devost D. , Danalache B. et al. Functional activity of the carboxyl-terminally extended oxytocin precursor Peptide during cardiac differentiation of embryonic stem cells. Stem Cells 2008;26(1):45-54.

Meirovich YF , Veinot JP , de Bold ML et al. Relationship between natriuretic peptides and inflammation: proteomic evidence obtained during acute cellular cardiac allograft rejection in humans. J Heart Lung Transplant 2008;27(1):31-7.

Zhou MS , Hernandez Schulman I. , Pagano PJ , Jaimes EA , Raij L. Reduced NAD(P)H oxidase in low renin hypertension: link among angiotensin II, atherogenesis, and blood pressure. Hypertens 2006;47(1):81-6.

Huang R. , Karve A. , Shah I. et al. Deletion of the mouse {alpha}-calcitonin gene-related peptide gene increases the vulnerability of the heart to ischemia/reperfusion Injury. Am J Physiol Heart Circ Physiol 2008;[Epub ahead of print].

Liberman M. , Bassi E. , Martinatti MK et al. Oxidant generation predominates around calcifying foci and enhances progression of aortic valve calcification. Arterioscler Thromb Vasc Biol 2007;[Epub ahead of print].

Hilgers RH , Todd J. Jr , Webb RC Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats. J Hypertens 2007;25:1687-97.

Hercule HC , Tank J. , Plehm R. et al. Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice. Exp Physiol 2007;92:1014-22.

Okruhlicova L. , Morwinski R. , Schulze W. et al. Autoantibodies against G-protein-coupled receptors modulate heart mast cells. Cell Mol Immunol 2007;4:127-33.