Spotlight on Renin

References 1. Hobart PM , Fogliano M. , O'Connor BA , Schaefer IM , Chirgwin JM Human renin gene: structure and sequence analysis. Proc Natl Acad Sci USA 1984;81:5026-30.

Danser AHJ , Derkx FHM , Schalekamp Madh , Hense HW , Riegger GAJ , Schunkert H. Determinants of interindividual variation of renin and prorenin concentrations: evidence for a sexual dimorphism of (pro)renin levels in humans. J Hypertens 1998;16:853-62.

Danser AHJ , Deinum J. Renin, Prorenin and the Putative (Pro)renin Receptor. Hypertens 2005;46:1069-76.

Lenz T. , Sealey JE , Maack T. et al. Half-life, hemodynamic, renal, and hormonal effects of prorenin in cynomolgus monkeys. Am J Physiol 1991;260:R804-R810.

Derkx FHM , Deinum J. , Lipovski M. , Verhaar M. , Fischli W. , Schalekamp Madh. Nonproteolytic `activation` of prorenin by active site-directed renin inhibitors as demonstrated by renin-specific monoclonal antibody. J Biol Chem 1992;267:22837-42.

Pitarresi TM , Rubattu S. , Heinrikson R. , Sealey JE Reversible cryoactivation of recombinant human prorenin. J Biol Chem 1992;267:11753-9.

Suzuki F. , Hayakawa M. , Nakagawa T. et al. Human prorenin has `gate and handle` regions for its non-proteolytic activation. J Biol Chem 2003;278:22217-22.

Deinum J. , Derkx FHM , Schalekamp Madh. Probing epitopes on human prorenin during its proteolytic and non-proteolytic activation. Biochim Biophys Acta 1998; 1388:386-96.

Galen FX , Devaux C. , Atlas S. et al. New monoclonal antibodies directed against human renin. Powerful tools for the investigation of the renin system. J Clin Invest 1984; 74:723-35.

Deinum J. , Derkx FHM , Schalekamp Madh. Improved immunoradiometric assay for plasma renin. Clin Chem 1999;45:847-54.

de Bruin RA , Bouhuizen A. , Diederich S. , Perschel FH , Boomsma F. , Deinum J. Validation of a new automated renin assay . Clin Chem 2004 ;50:2111-16.

van Kats JP , Danser AHJ , van Meegen JR , Sassen LM , Verdouw PD , Schalekamp Madh. Angiotensin production by the heart: a quantitative study in pigs with the use of radiolabeled angiotensin infusions. Circulation 1998;98: 73-81.

van Kats JP , Schalekamp Madh , Verdouw PD , Duncker DJ , Danser AHJ. Intrarenal angiotensin II: interstitial and cellular levels and site of production. Kidney Int 2001;60: 2311-17.

Danser AHJ , van Kats JP , Admiraal PJJ et al. Cardiac renin and angiotensins. Uptake from plasma versus in situ synthesis. Hypertension 1994;24:37-48.

Katz SA , Opsahl JA , Lunzer MM , Forbis LM , Hirsch AT Effect of bilateral nephrectomy on active renin, angiotensinogen, and renin glycoforms in plasma and myocardium. Hypertension 1997;30:259-66.

Hilgers KF , Veelken R. , Müller DN et al. Renin uptake by the endothelium mediates vascular angiotensin formation. Hypertension 2001;38:243-8.

Kantachuvesiri S. , Fleming S. , Peters J. et al. Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease . J Biol Chem 2001;276:3672-733.

Prescott G. , Silversides DW , Reudelhuber TL Tissue activity of circulating prorenin. Am J Hypertens 2002 ;15:280-5.

van den Eijnden Mmed , de Bruin RJA , de Wit E. et al. Transendothelial transport of renin-angiotensin system components. J Hypertens 2002;20:2029-37.

Campbell DJ , Valentijn AJ Identification of vascular renin-binding proteins by chemical cross-linking: inhibition of binding of renin by renin inhibitors . J Hypertens 1994;12: 879-90.

Müller DN , Fischli W. , Clozel JP et al. Local angiotensin II generation in the rat heart: role of renin uptake. Circ Res 1998;82:13-20.

Loudon M. , Bing RF , Thurston H. , Swales JD Arterial wall uptake of renal renin and blood pressure control. Hypertension 1983;5:629-34.

van Kesteren CAM , Danser AHJ , Derkx FHM et al. Mannose 6-phosphate receptor-mediated internalization and activation of prorenin by cardiac cells. Hypertension 1997;30:1389-96.

Nguyen G. , Delarue F. , Burcklé C. , Bouzhir L. , Giller T. , Sraer J. -D. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002;109:1417-27.

van den Eijnden Mmed , Saris JJ , de Bruin RJA et al. Prorenin accumulation and activation in human endothelial cells. Importance of mannose 6-phosphate receptors. Arterioscler Thromb Vasc Biol 2001;21:911-16.

Saris JJ , van den Eijnden Mmed , Lamers JMJ , Saxena PR , Schalekamp Madh , Danser AHJ. Prorenin-induced myocyte proliferation: no role for intracellular angiotensin II. Hypertension 2002;39:573-7.

Nguyen G. , Delarue F. , Berrou J. , Rondeau E. , Sraer JD Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen. Kidney Int 1996;50:1897-903.

Sealey JE , Catanzaro DF , Lavin TN et al. Specific prorenin/renin binding (ProBP). Identification and characterization of a novel membrane site. Am J Hypertens 1996;9:491-502.

Ichihara A. , Hayashi M. , Kaneshiro Y. et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the `handle` region for nonproteolytic activation of prorenin. J Clin Invest 2004 ;114:1128-35.