Abstract
This paper presents an overview of the definition, clinical features, epidemiology, classification, pathophysiology, evaluation and risk assessment and treatment pharmacodynamics of anaphylaxis from the perspective of Australasian paramedic practice.
Keywords
References
1.
Reber
L.L.
,
Hernandez
J.D.
,
Galli
S.J.
The pathophysiology of anaphylaxis. J Allergy Clin Immunol 2017 ; 140 : 335 –48 . Available at: https://linkinghub.elsevier.com/retrieve/pii/S0091674917310205
2.
Simons
F.E.R.
,
Ardusso
L.R.F.
,
Bilò
M.B.
International consensus on (ICON) anaphylaxis. World Allergy Organ J 2014 ; 7 : 9 . Available at: https://linkinghub.elsevier.com/retrieve/pii/S1939455119302406
3.
Kemp
S.F.
Pathophysiology of anaphylaxis. In:
Kelso
J.M.
,
Feldweg
A.M.
, editors. UpToDate. Waltham, MA : UpToDate ; 2020 .
4.Australasian Society of Clinical Immunology and Allergy. Anaphylaxis 2019. Available at: www.allergy.org.au/patients/about-allergy/anaphylaxis
5.
Jimenez-Rodriguez
T.
,
Garcia-Neuer
M.
,
Alenazy
L.A.
,
Castells
M.
Anaphylaxis in the 21st century: phenotypes, endotypes, and biomarkers. J Asthma Allergy 2018 ; 11 : 121 –42 . Available at: www.dovepress.com/anaphylaxis-in-the-21st-century-phenotypes-endotypes-and-biomarkers-peer-reviewed-article-JAA
6.
Campbell
R.L.
,
Kelso
J.M.
Anaphylaxis: acute diagnosis. In:
Walls
R.M.
,
Feldweg
A.M.
, editors. UpToDate. Waltham, MA : UpToDate ; 2020 .
7.Australasian Society of Clinical Immunology and Allergy. Allergy and Immune Diseases in Australia (AIDA) Report 2013. Balgowah, Australia ; 2013 .
8.House of Representatives Standing Committee on Health Aged Care and, Sport. Walking the allergy tightrope: addressing the rise of allergies and anaphylaxis in Australia. 2020 . Available at: www.allergy.org.au/images/docs/Walkingtheallergytightrope.pdf
9.
Turner
P.J.
,
Jerschow
E.
,
Umasunthar
T.
Fatal anaphylaxis: mortality rate and risk factors. J Allergy Clin Immunol Pract 2017 ; 5 : 1169 –78 . Available at: https://linkinghub.elsevier.com/retrieve/pii/S2213219817305159
10.
Xu
Y.S.
,
Kastner
M.
,
Harada
L.
Anaphylaxis-related deaths in Ontario: a retrospective review of cases from 1986 to 2011. Allergy Asthma Clin Immunol 2014 ; 10 : 38 . Available at: https://aacijournal.biomedcentral.com/articles/10.1186/1710-1492-10-38
11.
Tanno
L.K.
,
Bierrenbach
A.L.
,
Simons
F.E.R.
Critical view of anaphylaxis epidemiology: open questions and new perspectives. ibid. 2018 ; 14 : 12 . Available at: https://aacijournal.biomedcentral.com/articles/10.1186/s13223-018-0234-0
12.
Turner
P.J.
,
Worm
M.
,
Ansotegui
I.J.
Time to revisit the definition and clinical criteria for anaphylaxis? World Allergy Organ J 2019 ; 12 : 100066 . Available at: https://linkinghub.elsevier.com/retrieve/pii/S1939455119312207
13.
LoVerde
D.
,
Iweala
O.I.
,
Eginli
A.
,
Krishnaswamy
G.
Anaphylaxis. Chest 2018 ; 153 : 528 –43 . Available at: https://linkinghub.elsevier.com/retrieve/pii/S0012369217313326
14.
Montañez
M.I.
,
Mayorga
C.
,
Bogas
G.
Epidemiology, mechanisms, and diagnosis of drug-induced anaphylaxis. Front Immunol 2017 ; 8 . Available at: http://journal.frontiersin.org/article/10.3389/fimmu.2017.00614/full
15.
Fenny
N.
,
Grammer
L.C.
Idiopathic anaphylaxis. Immunol Allergy Clin North Am 2015 ; 35 : 349 –62 . Available at: https://linkinghub.elsevier.com/retrieve/pii/S0889856115000053
16.
Denholm
L.
,
Gallagher
G.
Physiology and pharmacology of nausea and vomiting. Anaesth Intensive Care Med 2018 ; 19 : 513 –6 . Available at: https://linkinghub.elsevier.com/retrieve/pii/S1472029918301541
17.
Bot
I.
,
Shi
G-P
,
Kovanen
P.T.
Mast cells as effectors in atherosclerosis. Arterioscler Thromb Vasc Biol 2015 ; 3 : 265 –71 . Available at: www.ahajournals.org/doi/10.1161/ATVBAHA.114.303570
18.
Lagraauw
H.M.
,
Wezel
A.
,
van der Velden
D.
,
Kuiper
J.
,
Bot
I.
Stress-induced mast cell activation contributes to atherosclerotic plaque destabilization. Sci Rep 2019 ; 9 : 2134 . Available at: www.nature.com/articles/s41598-019-38679-4
19.
Mali
S.
,
Jambure
R.
Anaphylaxis management: current concepts. Anesth Essays Res 2012 ; 6 : 115 . Available at: www.aeronline.org/text.asp?2012/6/2/115/108284
20.
Marone
G.
,
Genovese
A.
,
Varricchi
G.
,
Granata
F.
Human heart as a shock organ in anaphylaxis. Allergo J Int 2014 ; 23 : 60 –6 . Available at: http://link.springer.com/10.1007/s40629-014-0007-3
21.
Campbell
R.L.
,
Kelso
J.M.
Anaphylaxis: emergency treatment. In:
Walls
R.M.
,
Randolph
A.G.
,
Feldweg
A.M.
, editors. UpToDate. Waltham, MA : UpToDate ; 2020 .
22.
Ring
J.
,
Beyer
K.
,
Biedermann
T.
Guideline for acute therapy and management of anaphylaxis. Allergo J Int 2014 ; 23 : 96 –112 . Available at: http://link.springer.com/10.1007/s40629-014-0009-1
23.
Lee
J.K.
,
Vadas
P.
Anaphylaxis: mechanisms and management. Clin Exp Allergy 2011 ; 41 : 923 –38 . Available at: http://doi.wiley.com/10.1111/j.1365-2222.2011.03779.x
24.
Bock
S.A.
Fatal anaphylaxis. In:
Kelso
J.
,
Feldweg
A.
editors. UpToDate. Waltham, MA : UpToDate ; 2020 .
25.
Arts
L.
,
Lim
E.H.T.
,
van de Ven
P.M.
,
Heunks
L.
,
Tuinman
P.R.
The diagnostic accuracy of lung auscultation in adult patients with acute pulmonary pathologies: a meta-analysis. Sci Rep 2020 ; 10 : 1 –11 .
26.
Tupper
J.
Anaphylaxis: a review and update. Can Fam Physician 2010 ; 56 : 1009 –11 .
27.
Lieberman
P.L.
Biphasic and protracted anaphylaxis. In:
Kelso
J.M.
,
Feldweg
A.M.
editors. UpToDate. Waltham, MA : UpToDate ; 2020 .
28.
Simons
F.E.R.
,
Ardusso
L.R.F.
,
Bilò
M.B.
World Allergy Organization guidelines for the assessment and management of anaphylaxis. World Allergy Organ J 2011 ; 4 : 13 –37 . Available at: https://linkinghub.elsevier.com/retrieve/pii/S1939455119304132
29.
Maurer
M.
,
Magerl
M.
Hereditary angioedema: an update on available therapeutic options. JDDG J der Dtsch Dermatologischen Gesellschaft 2010 ; 8 : 663 –72 . Available at: http://doi.wiley.com/10.1111/j.1610-0387.2010.07450.x
30.
Craig
T.
,
Pürsün
E.A.
,
Bork
K.
WAO guideline for the management of hereditary angioedema. World Allergy Organ J 2012 ; 5 : 182 –99 . Available at: www.waojournal.org/content/5/12/182
31.
Ring
J.
,
Klimek
L.
,
Worm
M.
Adrenaline in the acute treatment of anaphylaxis. Dtsch Aerzteblatt Online 2018 ; Available at: www.aerzteblatt.de/10.3238/arztebl.2018.0528
32.
Kay
L.J.
,
Peachell
P.T.
Mast cell beta2-adrenoceptors. In: Mast Cells in Allergic Diseases. Basel : KARGER ; 2005 . p. 145 –53 . Available at: www.karger.com/Article/FullText/87641
33.
Wood
J.P.
Safety of epinephrine for anaphylaxis in the emergency setting. World J Emerg Med 2013 ; 4 : 245 . Available at: www.wjem.com.cn/default/articlef/index/id/257
34.
Peachell
P.
Regulation of mast cells by β-agonists. Clin Rev Allergy Immunol 2006 ; 31 : 131 –42 . Available at: http://link.springer.com/10.1385/CRIAI:31:2:131
35.
Sicherer
S.H.
Prescribing epinephrine for anaphylaxis self-treatment. In:
Kelso
J.M.
,
Feldweg
A.
, editors. UpToDate. Waltham, MA : UpToDate ; 2020 .
36.
Gosens
R.
,
Gross
N.
The mode of action of anticholinergics in asthma. Eur Respir J 2018 ; 52 : 1701247 . Available at: http://dx.doi.org/10.1183/13993003.01247-2017
37.
Marotta
S.E.
,
Belchikov
Y.
,
Banker
K.
,
Marshall
P.S.
Emergency management of acute severe asthma exacerbation in the adult population. J Asthma Allergy Educ 2010 ; 1 : 174 –9 . Available at: http://journals.sagepub.com/doi/10.1177/2150129710374232
38.
Williams
D.M.
Clinical pharmacology of corticosteroids. Respir Care 2018 ; 63 : 655 –70 . Available at: http://rc.rcjournal.com/lookup/doi/10.4187/respcare.06314
39.
Alqurashi
W.
,
Ellis
A.K.
Do corticosteroids prevent biphasic anaphylaxis? J Allergy Clin Immunol Pract 2017 ; 5 : 1194 –205 . Available at: https://linkinghub.elsevier.com/retrieve/pii/S2213219817303859
40.
Sheikh
A.
,
ten Broek
V.
,
Brown
S.G.A.
,
Simons
F.E.R.
H1-antihistamines for the treatment of anaphylaxis. Allergy 2007 ; 62 : 830 –7 . Available at: http://doi.wiley.com/10.1111/j.1398-9995.2007.01435.x
41.
Kawano
T.
,
Scheuermeyer
F.X.
,
Gibo
K.
H1-antihistamines reduce progression to anaphylaxis among emergency department patients with allergic reactions. Zehtabchi S, editor. Acad Emerg Med 2017 ; 24 : 733 –41 . Available at: http://doi.wiley.com/10.1111/acem.13147
42.
Hernández-Cascales
J.
Does glucagon have a positive inotropic effect in the human heart? Cardiovasc Diabetol 2018 ; 17 : 148 . Available at: https://cardiab.biomedcentral.com/articles/10.1186/s12933-018-0791-z
43.
Insuela
D.B.R.
,
Azevedo
C.T.
,
Coutinho
D.S.
Glucagon reduces airway hyperreactivity, inflammation, and remodeling induced by ovalbumin. Sci Rep 2019 ; 9 : 6478 . Available at: www.nature.com/articles/s41598-019-42981-6
44.
Soong
J.T.Y.
,
Soni
N.
Circulatory shock. Medicine (Baltimore) 2013 ; 41 : 64 –9 . Available at: https://linkinghub.elsevier.com/retrieve/pii/S1357303912002812
45.
Hale
A.J.
,
Ricotta
D.N.
,
Herzig
S.J.
,
William
J.H.
,
Freed
J.A.
A quantitative approach to dilutional anemia. J Hematol 2019 ; 8 : 86 –7 . Available at: www.thejh.org/index.php/JH/article/view/498