Abstract
Indocyanine green (ICG), with spectral absorption at 800--810 nm, is a chromophore that strongly absorbs and converts near-infrared laser energy into thermal energy. By directly injecting ICG into a tumor, selective tumor hyperthermia during laser irradiation occurs. In this study, 4 dogs with spontaneous tumors were injected in situ with a 0.25% energy. Thermal data were collected from multiple thermocouples placed within the tumor and tumor response was recorded. Tissue heating to ≥ 42°C was observed in all tumors. One dog had a complete remission, one dog had stable disease for 12 weeks, and the other 2 dogs developed progressive disease shortly after treatment. Results from this study demonstrate that chromophore-enhanced laser-induced hyperthermia can effectively and selectively heat canine tumors. However, tumor size and pigmentation of overlying skin are potentially limiting factors to the success of this novel c ancer treatment.
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