Preliminary application of real-time shear wave elastography to evaluate endometrial receptivity and predict pregnancy outcome

Abstract

BACKGROUND:

Endometrial receptivity is crucial for the establishment of a healthy pregnancy outcome. Previous research on endometrial receptivity primarily examined endometrial thickness, endometrial echo types, and endometrial blood supply.

OBJECTIVE:

To explore the differences in the elastic modulus of the endometrium in women with various pregnancy outcomes by real-time shear wave elastography (SWE) and to investigate its application value in evaluation of endometrial receptivity.

METHODS:

A total of 205 pregnant women who were admitted at Wenzhou People’s Hospital between January 2021 and December 2022 were selected. Three-dimensional transvaginal sonography and real-time shear wave elastography were performed in the proliferative phase and receptive phase of the endometrium, and the average elastic modulus of the endometrium in the two phases was obtained and compared. According to whether the pregnancy was successful or not, the participants were divided into the pregnancy group ( $n=$ 72) and non-pregnancy group ( $n=$ 133), and the differences in intimal thickness, 3D blood flow parameters, and average elastic modulus of intima were compared between the two groups.

RESULTS:

The average elastic modulus of the endometrium in the proliferative phase and receptive phase was (23.92 $\pm$ 2.31) kPa and (11.82 $\pm$ 2.24) kPa, respectively, and the difference was statistically significant $P<$ 0.05. The average elastic modulus of the endometrium in the pregnancy group and non-pregnancy group was (9.97 $\pm$ 1.08) kPa and (12.82 $\pm$ 2.06) kPa, respectively, and the difference was statistically significant $P<$ 0.05. The area under the curve of predicting pregnancy by the average elastic modulus of the endometrium in the receptive phase was 0.888 (0.841 $\sim$ 0.934), with corresponding $P$ value $<$ 0.05. The critical value was 11.15, with a corresponding sensitivity of 81.7% and specificity of 78.2%.

CONCLUSION:

Real-time shear wave elastography can quantitatively evaluate endometrial elasticity, indirectly reflect the endometrial phase, and provide a new diagnostic concept for evaluating endometrial receptivity and predicting pregnancy outcome in infertile patients.