Simulation of stress urinary incontinence for in-vitro studies

Abstract

A simulation system that generates dynamic bladder pressures for the use of testing and examining artificial urinary sphincters is designed, implemented, and compared to in-vivo measurements of Valsalva and coughing profiles. Cylinder and piston, which are integrated into the universal testing machine, simulating the bladder are connected with explanted sow urethras. The AMS 800™ artificial urinary sphincter closes the urethra with well-defined external pressures. In order to select appropriate profiles for the bladder pressure, 34 Valsalva and coughing profiles of 6 patients were evaluated with respect to amplitude, pressure raise, dwell time, and half width.