Abstract
The antagonizing effect of the β-adrenoceptor antagonist propranolol (PRP) on the desipramine (DMI)-induced regeneration of brain noradrenergic fibers was examined. The symmetrical sites of the rat frontal cortex were pretreated with 6-hydroxydopamine (6-OHDA). Then, the same cortical site of one hemisphere was infused with DMI, while the corresponding site of the other hemisphere was infused with DMI (1 mM) plus PRP (1 mM). The DMI-induced axonal regeneration was attenuated by PRP. This finding suggests that activation of β-adrenoceptors is involved at least in part in the regeneration of brain noradrenergic axons.
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