Abstract
This article reviews the relationships between alterations in several neurotransmitter systems and functional recovery of sensory and motor functions after trauma to the central nervous system in animal models. The timing of administration of promising therapeutic agents is discussed in relationship to the role of rehabilitation while the subject is under the influence of these agents. If caution is not employed in administering some drugs after injury, deleterious effects on recovery can be observed. Finally, attention is given to the mechanisms of drug-induced recovery and speculation concerning possible links to protein kinases and accessing of learned behaviors that are transiently depressed after brain injury.
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