Assessing Vitamin-D status and checking if low serum 25(OH)D is a factor in breast cancer (BC) for Southern Moroccan women.
MATERIALS/METHODS:
Study conducted in Morocco about women with BC (n = 90) and controls (n = 90). 25-hydroxy-vitamin-D biological analyzes executed during the first consultation. Social data and anthropometric parameters were collected for all participants.
RESULTS:
Women from urban areas constitued 67.78 % for the cases and 85.6% for the controls. The average age was 48.72±9.71 (cases) and 46.40±12.52 (controls). We found that 53.33% of cases and 40% of controls were postmenopausal and that hypovitaminosis-D affected 80 and 64.4% of cases and controls, respectively. Statistical analysis showed that hypovitaminosis-D was a significative risk factor for BC in Southern Moroccan women. The Odds Ratio was of 5 (p < 0.0001). The BC subtypes had Odds Ratios greater than 1. The highest value was obtained with Luminal B subtype (Odds ratio = 6.25; p = 0.0007).
CONCLUSION:
This study reinforces the evidence implicating hypovitaminosis-D among modifiable risk factors for BC. Further studies are needed to assess the extent of hypovitaminosis-D in Moroccan women with BC.
International Agency of Research on Cancer. Global Cancer Observatory. Available from https://gco.iarc.fr.
2.
MichelsKB, MohllajeeAP, Roset-BahmanyarE, BeehlerGP, MoysichKBDiet and breast cancer: a review of the prospective observational studies. Cancer. 2007;109(12 Suppl):2712–49.
3.
CharoenngamN, ShirvaniA, HolickMFVitamin D for skeletal and non-skeletal health: What we should know. J Clin Orthop Trauma. 2019;10(6):1082–93. doi: 10.1016/j.jcot.2019.07.004. Epub 2019 Jul 13. PMID: 31708633; PMCID: PMC6834997.
4.
HolickMF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–81. doi: 10.1056/NEJMra070553. PMID: 17634462.
5.
LipsP. Vitamin D status and nutrition in Europe and Asia. J Steroid Biochem Mol Biol. 2007;103(3-5):620–5.
6.
AmreinK, ScherklM, HoffmannM, Neuwersch-SommereggerS, KöstenbergerM, TmavaBerisha A, et al. Vitamin D deficiency 2.0: an update on the current status worldwide. Eur J Clin Nutr. 2020;74(11):1498–513.
7.
WackerM, HolickMFVitamin D - effects on skeletal and extraskeletal health and the need for supplementation. Nutrients. 2013;5(1):111–48.
8.
JeonSM, ShinEAExploring vitamin D metabolism and function in cancer. Exp Mol Med. 2018;50(4):1–14.
9.
NormanAW. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr. 2008;88(2):491–9.
10.
FeldmanD, KrishnanAV, SwamiS, GiovannucciE, FeldmanBJThe role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014;14(5):342–57.
11.
VrielingA, SeiboldP, JohnsonTS, HeinzJ, ObiN, KaaksR, et al. Circulating 25-hydroxyvitamin D and postmenopausal breast cancer survival: Influence of tumor characteristics and lifestyle factors?Int J Cancer. 2014;134(12):2972–83.
12.
FerreiraIB, Marinho EdaC, CustódioID, GontijoCA, PaivaCE, CrispimCA, et al. Food intake and the nutritional status of women undergoing chemotherapy. Cien Saude Colet. 2016;21(7):2209–18.
13.
McCulloughML, StevensVL, PatelR, JacobsEJ, BainEB, HorstRL, et al. Serum 25-hydroxyvitamin D concentrations and postmenopausal breast cancer risk: a nested case control study in the Cancer Prevention Study-II Nutrition Cohort. Breast Cancer Res. 2009;11:R64.8.
14.
AtoumM, AlzoughoolFVitamin D and Breast Cancer: Latest Evidence and Future Steps. Breast Cancer (Auckl). 2017;11:1178223417749816.
15.
HatseS, LambrechtsD, VerstuyfA, SmeetsA, BrouwersB, VandorpeT, BrouckaertO, PeutemanG, LaenenA, VerlindenL, KriebitzschC, DieudonnéAS, ParidaensR, NevenP, ChristiaensMR, BouillonR, WildiersHVitamin D status at breast cancer diagnosis: correlation with tumor characteristics, disease outcome, and genetic determinants of vitamin D insufficiency. Carcinogenesis. 2012;33(7):1319–26. doi: 10.1093/carcin/bgs187. Epub 2012 May 23. PMID: 22623648.
16.
YousefFatimah M, JacobsElizabeth T, KangPaul T, HakimIman A, ScottGoing, YousefJehad M, Al-RaddadiRajaa M, KumosaniTaha A, ThomsonCynthia A. Vitamin D status and breast cancer in Saudi
Arabian women: case-control study. The American Journal of Clinical Nutrition. 2013;98(1):105–10, https://doi.org/10.3945/ajcn.112.054445.
HolickMF, BinkleyNC, Bischoff-FerrariHA, GordonCM, HanleyDA, HeaneyRP, et al. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30.
20.
GoldhirschA, WinerEP, CoatesAS, GelberRD, Piccart-GebhartM, ThürlimannB, SennHJ; Panel members. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann Oncol. 2013;24(9):2206–23. doi: 10.1093/annonc/mdt303. Epub 2013 Aug 4. PMID: 23917950; PMCID: PMC3755334.
21.
BilinskiK, BoyagesJ. Association between 25-hydroxyvitamin D concentration and breast cancer risk in an Australian population: an observational case-control study. Breast Cancer Res Treat. 2013;137(2):599–607.
22.
SofiNY, JainM, KapilU, SeenuV, KamalVK, PandeyRM. Nutritional risk factors and status of serum 25(OH)D levels in patients with breast cancer: A case control study in India. J Steroid Biochem Mol Biol. 2018;175:55–59. Australian population: an observational case-control study. Breast Cancer Res Treat. 2013;137(2):599-607.
23.
YousefFM, JacobsET, KangPT, HakimIA, GoingS, YousefJM, et al. Vitamin D status and breast cancer in Saudi Arabian women: case-control study. Am J Clin Nutr. 2013;98(1):105–10.
24.
JamshidinaeiniY, AkbariME, AbdollahiM, AjamiM, DavoodiSHVitamin D Status and Risk of Breast Cancer in Iranian Women: A Case-Control Study. J Am Coll Nutr. 2016;35(7):639–46.
25.
AmirE, CecchiniRS, GanzPA, CostantinoJP, BeddowsS, HoodN, et al. 25-Hydroxy vitamin-D, obesity, and associated variables as predictors of breast cancer risk and tamoxifen benefit in NSABP-P1. Breast Cancer Res Treat. 2012;133(3):1077–88.
26.
Shekarriz-FoumaniR, KhodaieFThe Correlation of Plasma 25-Hydroxyvitamin D Deficiency With Risk of Breast Neoplasms: A Systematic Review. Iran J Cancer Prev. 2016;9(3):e4469.
27.
EstébanezN, Gómez-AceboI, PalazuelosC, LlorcaJ, Dierssen-SotosTVitamin D exposure and Risk of Breast Cancer: a meta-analysis. Sci Rep. 2018;8(1):9039.
28.
McNamaraM, RosenbergerKDThe Significance of Vitamin D Status in Breast Cancer: A State of the Science Review. J Midwifery Womens Health. 2019;64(3):276–88.
29.
McDonnellSL, BaggerlyCA, FrenchCB, BaggerlyLL, GarlandCF, GorhamED, et al. Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations ≥60 vs < 20 ng/ml (150 vs 50 nmol/L): Pooled analysis of two randomized trials and a prospective cohort. PLoS One. 2018;13(6):e0199265.
30.
VanceV, CampbellS, McCargarL, MourtzakisM, HanningRDietary changes and food intake in the first year after breast cancer treatment. Appl Physiol Nutr Metab. 2014;39(6):707–14.
31.
KimHJ, LeeYM, KoBS, LeeJW, YuJH, SonBH, et al. Vitamin D deficiency is correlated with poor outcomes in patients with luminal-type breast cancer. Ann Surg Oncol. 2011;18(7):1830–6.
32.
TommieJL, PinneySM, Nommsen-RiversLASerum Vitamin D Status and Breast Cancer Risk by Receptor Status: A Systematic Review. Nutr Cancer. 2018;70(5):804–20.
33.
WhitingSusan J, CalvoMona S. Nutrition and Lifestyle Effects on Vitamin D Status. Editor: FeldmanDavid, Vitamin D Third edition. Academic Press, USA. 2011.
34.
LaPortaE, WelshJModeling vitamin D actions in triple negative/basal-like breast cancer. J Steroid Biochem Mol Biol. 2014;144(Pt A):65–73. doi: 10.1016/j.jsbmb.2013.10.022.
35.
YaoS, AmbrosoneCBAssociations between vitamin D deficiency and risk of aggressive breast cancer in African-American women. J Steroid Biochem Mol Biol. 2013;136:337–41.
