An expeditious synthesis of 1,2,4-triazolinones appended to 1,3-thiazoles using zinc triflate as catalyst

Abstract

A convenient and high yielding method was developed for the ring transformation of 1,3,4-oxadiazolinones (2a–e) from 3-arylsydnones (1a–e) to 1,2,4-triazolinones (3a–e) using zinc triflate as catalyst and then appended to 1,3-thiazoles via an imino bridge in one-pot reaction with excellent yields. The novel compounds were further scored for c logP values, drug likeliness, drug score and toxicity rates using molecular OSIRIS property explorer. Selective compounds were also screened for antimicrobial studies.