A high flux neutron source based on a vacuum-insulated tandem accelerator (VITA) and a lithium target has been proposed and developed at the Budker Institute of Nuclear Physics in Novosibirsk, Russia. We describe VITA which provides a dc proton/deuteron beam with an energy within a range of 0.6–2.3 MeV with a current from 1 nA to 10 mA. VITA is also capable of producing α-particles through the 7Li(p,α)α and 11B(p,α) reactions, 478 keV photons through the 7Li(p,p)7Li reaction and positrons through the 19F(p,e+e−)16O reaction. We present several applications of this source: boron neutron capture therapy, nuclear cross sections determination, lithium target study, radiation blistering of metals during proton implantation and the radiation testing of promising materials.
BayanovB.F.BelovV.P.BenderE.D.BokhovkoM.V.DimovG.I.KononovV.N.KononovO.E.KuksanovN.K.PalchikovV.E.PivovarovV.A.SalimovR.A.SilvestrovG.I.SkrinskyA.N. and TaskaevS.Y., Accelerator based neutron source for the neutron-capture and fast neutron therapy at hospital, Nuclear Instr. and Methods in Physics Research, A413(2–3) (1998), 397–426. doi:10.1016/S0168-9002(98)00425-2.
4.
BikchurinaM.BykovT.KasatovD.KolesnikovI.MakarovA.ShchudloI.SokolovaE. and TaskaevS., The measurement of the neutron yield of the 7Li(p,n)7Be reaction in lithium targets, Biology10 (2021), 824. doi:10.3390/biology10090824.
5.
BykovT.GoloshevskiiN.GromilovS.KasatovD.KolesnikovI.KoshkarevA.MakarovA.RuktuevA.ShchudloI.SokolovaE. and TaskaevS., In situ study of the blistering effect of copper with a thin lithium layer on the neutron yield in the 7Li(p,n)7Be reaction, Nuclear Inst. and Methods in Physics Research B481 (2020), 62–81. doi:10.1016/j.nimb.2020.08.010.
6.
BykovT.KasatovD.KoshkarevA.MakarovA.LeonovV.PorosevV.SavinovG.SavinovS.ShchudloI.TaskaevS. and VerkhovodG., Evaluation of depth-dose profiles in a water phantom at the BNCT facility at BINP, JINST16 (2021), P10016. doi:10.1088/1748-0221/16/10/P10016.
7.
DymovaM.DmitrievaM.KuliginaE.RichterV.SavinovS.ShchudloI.SychevaT.TaskaevaI. and TaskaevS., Method of measuring high-LET particles dose, Radiation Research196 (2021), 192–196. doi:10.1667/RADE-21-00015.1.
8.
KanyginV.KasatovaA.ZavjalovE.RazumovI.KilesnikovS.KichiginA.SolovievaO.TsygankovaA.TaskaevS.KasatovD.SychevaT. and ByvaltsevV., Effects of boron neutron capture therapy on the growth of subcutaneous xenografts of human colorectal adenocarcinoma SW-620 in immunodeficient mice, Bulletin of Experimental Biology and Medicine172(9) (2021), 356–361. doi:10.47056/0365-9615-2021-172-9-356-361.
9.
KanyginV.KichiginA.ZaboronokA.KasatovaA.PetrovaE.TsygankovaA.ZavjalovE.MathisB. and TaskaevS., In vivo accelerator-based boron neutron capture therapy for spontaneous tumors in large animals: Case series, Biology11 (2022), 138. doi:10.3390/biology11010138.
10.
PopovaT.DymovaM.KorolevaL.ZakharovaO.LisitskiyV.RaskolupovaV.SychevaT.TaskaevS.SilnikovV. and GodovikovaT., Homocystamide conjugates of human serum albumin as a platform to prepare bimodal multidrug delivery systems for boron–neutron capture therapy, Molecules26 (2021), 6537. doi:10.3390/molecules26216537.
11.
SauerweinW.A.G.WittigA.MossR. and NakagawaY. (eds), Neutron Capture Therapy: Principles and Applications, Springer, Heidelberg, Germany, 2012.
12.
ShoshinA.BurdakovA.IvantsivskiyM.PolosatkinS.KlimenkoM.SemenovA.TaskaevS.KasatovD.ShchudloI.MakarovA. and DavydovN., Qualification of boron carbide ceramics for use in ITER ports, IEEE Transactions on Plasma Science (2020), 1474–1478. doi:10.1109/TPS.2019.2937605.
13.
ShoshinA.BurdakovA.IvantsivskiyM.PolosatkinS.SemenovA.SulyaevY.ZaitsevE.PolozovaP.TaskaevS.KasatovD.ShchudloI. and BikchurinaM., Test results of boron carbide ceramics for ITER port protection, Fusion Engineering and Design168 (2021), 112426. doi:10.1016/j.fusengdes.2021.112426.
14.
ShoshinA.BurdakovA.IvantsivskiyM.ReichleR.UdintsevV.GuiraoJ.PakS.ZvonkovA.KravtsovD.SorokinaN.SulyaevY.ListopadA.GavrilenkoD.TaskaevA.ShabuninE.SeryominV.ShiyankovS.ZaytcevE.SeleznevP.SemenovA.PolosatkinS.TaskaevS.KasatovD.ShchudloI.BikchurinaM.ModestovV.SmirnovA.PozhilovA.LobachevA.LoginovI.ShagnievO.KirienkoI. and BuslakovI., Integration of ITER diagnostic ports at the Budker institute, Fusion Engineering and Design178 (2022), 113114. doi:10.1016/j.fusengdes.2022.113114.
15.
TaskaevS.BikchurinaM.BykovT.KasatovD.KolesnikovI.MakarovA.OstreinovG.SavinovS. and SokolovaE., Cross-section measurement for the 7Li(p,alfa)4He reaction at proton energies 0.6–2 MeV, Nuclear Inst. and Methods in Physics Research B525 (2022), 55–61. doi:10.1016/j.nimb.2022.06.010.
16.
TaskaevS.BykovT.KasatovD.KolesnikovI.KoshkarevA.MakarovA.SavinovS.ShchudloI. and SokolovaE., Measurement of the 7Li(p,p’gamma)7Li reaction cross-section and 478 keV photon yield from a thick lithium target at proton energies from 0.65 MeV to 2.225 MeV, Nuclear Inst. and Methods in Physics Research B502 (2021), 85–94. doi:10.1016/j.nimb.2021.06.010.
17.
VorobyevaM.DymovaM.NovopashinaD.KuliginaE.TimoshenkoV.KolesnikovI.TaskaevS.RichterV. and VenyaminovaA., Tumor cell-specific 2’-fluoro RNA aptamer conjugated with closo-dodecaborate as a potential agent for boron neutron capture therapy, International Journal of Molecular Sciences22 (2021), 7326. doi:10.3390/ijms22147326.
18.
ZaboronokA.TaskaevS.VolkovaO.MechetinaL.KasatovaA.SychevaT.NakaiK.KasatovD.MakarovA.KolesnikovI.ShchudloI.BykovT.SokolovaE.KoshkarevA.KanyginV.KichiginA.MathisB.IshikawaE. and MatsumuraA., Gold nanoparticles permit in situ absorbed dose evaluation in boron neutron capture therapy for malignant tumors, Pharmaceutics13 (2021), 1490. doi:10.3390/pharmaceutics13091490.
