The attractive properties of the hypercube graph such as its diameter, good connectivity, and symmetry have made it a popular topology for the design of multi-computer interconnection networks. Efforts to improve some of these properties have led to the evolution of hypercube variants. Let c be the proper coloring of graph G, where the neighboring vertices will get individual colors. Coloring c is irregular if distinct vertices have distinct color codes and the least number of colors that ought to receive an irregular coloring is the irregular chromatic number, χ
ir
(G). In this paper, we discuss the irregular coloring and find the irregular chromatic number for the hypercube graph Q
n
and some of its variants using binomial coefficients for the Locally twisted cube graph LTQ
n
, Crossed cube graph CQ
n
and two types of Fractal cubic network graph FCNG1 (k) and FCNG2 (k).