A supernatural multipurpose plant Sea buckthorn ( Hippophae rhamnoides L.): An updated overview of its folk traditional uses,phytochemical profile and biological activities
Restricted accessReview articleFirst published online March 28, 2023
A supernatural multipurpose plant Sea buckthorn ( Hippophae rhamnoides L.): An updated overview of its folk traditional uses,phytochemical profile and biological activities
Sea buckthorn (SBT) (Hippophae rhamnoides L.), a shrub rich with a huge variety of vitamins, antioxidants and other biologically active constituents with pharmacological and cosmaceutical applications.
OBJECTIVE:
The current review aims to compile the recent reported data on the ethnobotany, phytochemistry, biological activities and cosmaceutical uses of SBT plant from different regions of the world.
METHODS:
A wide-ranging inquiry on SBT was done electronically on the basis of articles and abstracts published in peer-reviewed journals, issued in conference proceedings, government reports, books, Master’s and Ph.D. theses, etc. The research was carried out in different international scientific databases like Academic Search, Biological Abstracts, BIOSIS, BioOne Previews, CabDirect, Cochrane Library, Pubmed/Medline, GeoRef, Google Scholar, JSTOR, Journal Citation Reports, Mendeley, Publons, Researchgate, Scopus, SciELO, Springer Link, Science Direct, Web of Science, Taylor and Francis with particular keywords.
RESULTS:
A total of 185 published papers were assessed through the search approach and 162 papers were included published on SBT. It was evident from the literature search that the uses of SBT as traditional medicine so far against nearly 50 health related complications in more than 18 regions of the world are still a common practice where the decoction of leaves and juice/paste from berries/fruits of SBT were the common administration modes. Data on the phytochemical profile of SBT revealed more than 50 diverse reported groups of compounds with remarkable antioxidant activity against reactive oxygen species (ROS) using DPPH, FRAP and ABTS as common methods. Moreover to-date, the reported antimicrobial activity of SBT uncovered that the extracts from SBT were examined in contradiction of 32 strains of bacteria and 15 strains of fungus with significant inhibitory actions against the bacterial and fungal strains. The SBT extracts actions reported so far on different viral disease categories displayed active inhibition of the growth of nearly 15 different viral strains. The reported anticancer activity of compounds in SBT extracts to date evidenced remarkable results against more than 20 different cancer cell lines/types. Moreover, SBT oil containing fatty acids, tocopherols and carotenoids is effectively used with cosmetic applications for skin care.
CONCLUSIONS:
Conclusively, SBT is rich with several remarkable phytochemicals that may have diverse biological actions and for that reason reassure the use of decoctions and/or infusions of SBT as folk traditional medicine around the world. Conversely, it is essential to explore the molecular mechanisms of compounds responsible for biological activities of SBT and to advance in the research of clinical uses and development of SBT based therapeutic and cosmetic products.
RousiA. The genus Hippophae L. A taxonomic study. Ann Bot Fenn. 1971;8:177–227.
2.
KatoK, KanayamaY, OhkawaW, KanahamaK. Nitrogen fixation in seabuckthorn (Hippophae rhamnoides L.) root nodules and effect of nitrate on nitrogenase activity. J Jpn Soc Hortic Sci. 2007;76:185–90.
3.
SinghV. Geographical adaptation and distribution of Sea buckthorn. In: SinghV(ed) Sea buckthorn (Hippophae L.)—a multipurpose wonder plant (vol I). Indus Publishing Company, New Delhi, 2003, pp. 21–34.
4.
PiłatB, BieniekA, ZadernowskiR. Common sea buckthorn (Hippophae Rhamnoides l.) As an alternative orchard plant. Pol J NatSci. 2015;30(4):417–30.
5.
XuMY, SunXX, TongWX. Medical research and development of Sea buckthorn. Hippophae. 1994;7:32–40.
6.
KimJS, KwonYS, SaYJ, KimMJ. Isolation and identification of Sea buckthorn (Hippophae rhamnoides) phenolics with antioxidant activity and α-glucosidase inhibitory effect. J Agric Food Chem. 2011;59(1):138–44. doi: 10.1021/jf103130a
7.
HuI, XiaJ, TuX. Achievements and experiences of construction and development of Hippophae rhamnoides resource in China. Sci Soil Water Cons. 2008;6:98–102.
8.
OyungerelD, JuuperelmaaU, NasanjargalD, AltangooG, BattumurS. Distribution and genetic resource of Mongolian natural wild Sea buckthorn (Hippophae rhamnoides L.). Mongol J Agric Sci. 2014;13:55–9. doi: 10.5564/mjas.v13i2.516
9.
GonchigsumlaaG. Competitiveness of Pastoral Livestock Production and Sea buckthorn Farming in Mongolia: Application of Policy Analysis Matrix. Ph.D. Thesis, Georg-August-Universität Göttingen, Göttingen, Germany, 2016.
10.
StobdanT, PhunchokT. Value chain analysis of Sea buckthorn (Hippophae rhamnoides L.) in Leh Ladakh; Ministry of agriculture and farmer welfare, government of India: New Dehli, India, 2017.
11.
ChadburnH, WilsonB. Elaeagnus rhamnoides. The IUCN red list of threatened species; 2018. Accessed on 746 25th July 2022. doi:10.2305/IUCN.UK.2018-1.RLTS.T55686342A119996497.en
12.
Joint Nature Conservation Committee (JNCC). Second report by the UK under article 17 on the implementation of the habitats directive from January 2001 to December 2006. Conservation status assessment for: H2160: Dunes with Hippophae rhamnoides. Peterborough: Joint Nature Conservation Committee (JNCC); 2007.
13.
KallioH, YangB, PeippoP. Effects of different origins and harvesting time on vitamin C, tocopherols, and tocotrienols in Sea buckthorn (Hippophae rhamnoides L.) berries . J Agric Food Chem. 2002;50:6136–42. doi: 10.1021/jf020421v
14.
JamyansanY, BadgaaD. Bioactive substances of Mongolian Sea buckthorn (Hippophae rhamnoides L.). In Sea buckthorn (Hippophae rhamnoides L.): A multipurpose wonder plant; Singh, V., Ed.; Daya Publishing House: New Delhi, India, 2005, pp. 145–50.
15.
UpadhyayNK, KumarMY, GuptaA. Antioxidant, cytoprotective and antibacterial effects of sea buckthorn (Hippophae rhamnoides L.) leaves. Food and Chem Toxicol. 2010;48:3443–8. doi: 10.1016/j.fct.2010.09.019
16.
AnderssonSC, OlssonME, JohanssonE, RumpunenK. Carotenoids in Sea Buckthorn (Hippophae rhamnoides L.) berries during ripening and use of pheophytin a as a maturity marker. J Agric Food Chem. 2008;57:250–8.
17.
BaoruY, RiinaM, PenttiH, HeikkiP. Phytosterols in sea buckthorn (Hippophae rhamnoides L.) berries: Identification and effects of different origins and harvesting times. J Agric Food Chem. 2001;49(11):5620–9. doi: 10.1021/jf010813m
18.
GreyC, WidénC, AdlercreutzP, RumpunenK, DuanRD. Antiproliferative effects of Sea buckthorn (Hippophaerhamnoides L.) extracts on human colon and liver cancer celllines. Food Chem. 2010;120(4):1004–10. doi: 10.1016/j.foodchem.2009.11.039
19.
GuptaR, SinghV. Mineral composition of sea buckthorn (Hippophae rhamnoides L.). In Sea Buckthorn (Hippophae rhamnoides L.): A Multipurpose Wonder Plant; Singh, V., Ed.; Daya Publishing House: New Delhi, India, 2005, pp. 272–84.
20.
YangB, KallioHP. Fatty acid composition of lipids in Sea Buckthorn (Hippophae rhamnoides L.) berries of different origins. J Agric Food Chem. 2001;49:1939–47. doi: 10.1021/jf001059s
21.
GuptaA, UpadhyayNK, SawhneyRC and KumarR. A poly-herbal formulation accelerates normal and impaired diabetic wound healing. Wound Rep Regen. 2008;16(6):784–90. doi: 10.1111/j.1524-475X.2008.00431.x
MaheshwariDT, Yogendra KumarMS, VermaSK, SinghVK, SinghSN. Antioxidant and hepatoprotective activities of phenolic rich fraction of Sea buckthorn (Hippophae rhamnoides L.) leaves. Food Chem Toxicol. 2001;49(9):2422–8. doi: 10.1016/j.fct.2011.06.061
24.
PopRM, SocaciuC, PinteaA, BuzoianuAD, SandersMG, GruppenH, et al. UHPLC/PDA–ESI/MS analysis of the main berry and leaf flavonol glycosides from different carpathian Hippophae rhamnoides L.varieties. Phytochem Anal. 2013;24:484–92. doi: 10.1002/pca.2460
25.
PadwadY, GanjuL, JainM, ChandaS, KaranD, BanerjeeKP, et al. Effect of leaf extract of Sea buckthorn on lipopolysaccharide induced inflammatory response in murine macrophages. Int Immunopharmacol. 2006;6:46–52. doi: 10.1016/j.intim2005.07.015
26.
KwonDJ, BaeYS, JuSM, GohAR, ChoiSY, ParkJ. Casuarinin suppresses TNF-a-induced ICAM-1 expression via blockade of NF-jB activation in HaCaT cells. Biochem Biophy Res Comm. 2011;409:780–5. doi: 10.1016/j.bbrc.2011.05.088
27.
NarayananS, RumaD, GitikaB, SharmaSK, PaulineT, SaiRam M, et al. Antioxidant activities of seabuckthorn (Hippophae rhamnoides) during hypoxia induced oxidative stress in glial cells. Mol Cell Biochem. 2005;278:9–14. doi: 10.1007/s11010-005-7636-2
28.
GeethaS, JayamurthyP, PalK, PandeyS, SawhneyRC. Hepatoprotective activity of Sea buckthorn (Hippophae rhamnoides L.) against carbon tetrachloride induced hepatic damage in rats. J Sci Food Agric. 2008;88:1592–7. doi: 10.1002/jsfa.3255
29.
HibasamiH, MitaniA, KatsuzakiH, ImaiK, YoshiokaK, KomiyaT. Isolation of five types of flavonol from seabuckthorn (Hippophae rhamnoides) and induction of apoptosis by some of the flavonols in human promyelotic leukemia HL-60 cells. Int J Mol Med. 2005;15:805–9.
30.
ChauhanAS, NegiPS, RamtekeRS. Antioxidant and antibacterial activities of aqueous extract of Sea buckthorn (Hippophae rhamnoides) seeds. Fitoterapia. 2007;78:590–2. doi: 10.1016/j.fitote.2007.06.004
31.
JainM, GanjuL, KatiyalA, PadwadY, MishraKP, ChandaS, et al. Effect of Hippophae rhamnoides leaf extract against Dengue virus infection in human blood-derived macrophages. Phytomedicine. 2008;15:793–9. doi: 10.1016/j.phymed.2008.04.017
32.
JaśniewskaA, DiowkszA. Wide spectrum of active compounds inSea Buckthorn (Hippophae rhamnoides) for disease preventionand food production. Antioxidants. 2021;10(8):1279. doi: 10.3390/antiox10081279
33.
ZebA. Important therapeutic uses of Sea buckthorn (Hippophae): A review. J Biol Sci. 2004;4(5):687–93. doi: 10.3923/jbs.2004.687.693
34.
RopO, ErcisliS, MlcekJ, JurikovaT, HozaI. Antioxidant and radical scavenging activities in fruits of 6 Sea buckthorn (Hippophae rhamnoides L.) cultivars. Turk J Agric Forest. 2014;38:224–32.
35.
OlasB, SkalskiB, UlanowskaK. The anticancer activity of Sea buckthorn [Eleagnus rhamnoides (L.) A.Nelson]. Front Pharmacol. 2018;9:232. doi: 10.3389.fphar.2018.00232
36.
OsawaruME, Dania-OgbeFM. Ethnobotanical studies of West African Okra [Abelmoschuscaillei (A.chev) stevels] from some tribes of south western Nigeria. Scient World J. 2010;5:1. doi: 10.4314/swj.v5i1.61484
37.
HussainA, HayatMQ, SahreenS, AinQU, BokhariSAI. Pharmacological promises of genus Artemisia (Asteraceae): A review. Proceed Pak Acad Sci: B. Life Environ Sci. 2017;54(4):265–87.
38.
HussainA, HayatMQ, BokhariSAI. Some important species of the genus Artemisia L.(Asteraceae) from northeastern (Gilgit-Baltistan) Pakistan and their folk medicinal uses. Proceed Pak Acad Sci: B. Life and Environ Sci. 2020;57(2):35–48.
39.
KoelzWN. Notes on the ethnobotany of Lahaul, a province of the Punjab. Quart J Crude Drug Res. 1979;17:1–56. doi: 10.3109/13880207909083272
40.
JainSK. Dictionary of Indian folk medicine and ethnobotany. Deep publications, New Delhi, India, 1991.
41.
BrijLal, AhujaPS, GuptaAK. Application of Sea buckthorn in Amchi system of medicine. In: Singh V, Khosla PK. (Eds.), Sea buckthorn–A resource for health and environment in twenty first century. CSK Himachal Pradesh Agricultural University, Palampur and Indian Society of Tree Scientists, Solan; 2001, pp. 239-42.
42.
ZadernowskiR, NaczkM, CzaplickiS. et alComposition of phenolic acids in sea buckthorn (Hippophae rhamnoides L.) berries. J Amer Oil Chem Soc. 2005;82:175–9. doi.org/10.1007/s11746-005-5169-1
43.
MaityD, PradhanN, ChauhanAS. Folk uses of some medicinal plants from North Sikkim. Ind J Trad Knowl. 2004;3(1):66–71.
44.
KunwarRM, AdhikarN. Ethnomedicine of Dolpa district, Nepal: The plants, their vernacular names and uses. Iyonia. 2005;8(1):43–9.
45.
BhattaraiS, ChaudharyRP, TaylorRS. Ethnomedicinal plants used by the people of Manang district, central Nepal. J Ethnobiol Ethnomed. 2006;2:41. doi: 10.1186/1746-4269-2-41
46.
KhanSW, KhatoonS. Ethnobotanical studies on useful trees and shrubs of Haramosh and Bugrote valleys, in Gilgit Northern areas of Pakistan. Pak J Bot. 2007;39(3):699–710.
47.
MemonAH, RindFMA, LaghariMGH, MughalUR, MemonN, GilalRA, et al. Common folk medicinal and ethnomedicinal uses of thirty medicinal plants of districts Dadu and Jamshoro, Sindh, Pakistan. Sindh Uni Res J (Sci Ser). 2008;40(2):89–108.
48.
SinghKN, LalB. Ethnomedicines used against four common ailments by the tribal communities of Lahaul-Spiti in western Himalaya. J Ethnopharmacol. 2008;115:147–59. doi: 10.1016/j.je2007.09.017
49.
AfzalS, AfzalN, AwanMR, KhanTS, GilaniA, KhanumR, et al. Ethno-botanical studies from Northern Pakistan. J Ayub Med Coll Abbott. 2009;21(1):52–7.
50.
PhaniKG, GuptaS, PalMM, SinghSB. Ethnobotanical studies of Nubra valley - A cold arid zone of Himalaya. Ethnobot Leafl. 2009;13:752–65.
51.
DhyaniD, MaikhuriRK, MisraS, RaoKS. Endorsing the declining indigenous ethnobotanical knowledge system of Seabuckthorn in Central Himalaya, India. J Ethnopharmacol. 2010;127(2):329–34. doi: 10.1016/j.je2009.10.037
52.
SuryakumarG, GuptaA. Medicinal and therapeutic potential of Sea buckthorn (Hippophae rhamnoides L.). J Ethnopharmacol. 2011;138(2):268–78. doi: 10.1016/j.je2011.09.024
53.
FahadS, BanoA. Ethnobotanical and physiological studies of some endangered plant species collected from two different altitudes in Gilgit Baltistan. Pak J Bot. 2012;44:165–70.
54.
AwanMR, ShahM, JanG, JamalZ. Ethno-botanical studies from Northern Pakistan. EPS global medical development Inc. Huhot, China, Natural Sciences Development Forum August 3rd-5th–2011 Abstract published; 2011, p. 118.
55.
SinghA, ButolaJS, SamantSS, SharmaP, LalM, MarpaS. Indigenous techniques of product development and economic potential of Sea buckthorn: A case study of cold desert region of Himachal Pradesh, India. Proceed Nat Acad Sci, Ind Sect B: Biol Sci. 2012;82(3):391–8.
56.
LiF, ZhuoJ, LiuB, JarvisD, LongC. Ethnobotanical study on wild plants used by Lhoba people in Milin County, Tibet. J Ethnobiol Ethnomed. 2015;11:23. doi: 10.1186/s13002-015-0009-3
57.
AbbasZ, KhanSM, AbbasiAM, PieroniA, UllahZ, IqbalM, et al. Ethnobotany of the Balti community, Tormik valley, Karakorum range, Baltistan, Pakistan. J Ethnobiol Ethnomed. 2016;12(1):38. doi: 10.1186/s13002-016-0114-y
58.
GyawaliR, PaudelH. Plant bio-resources used in ethno-veterinary practices in Jumla District. Nep Veter J. 2017;34:128–34. doi: 10.3126/nvj.v34i0.22915
59.
MalikK, AhmadM, ZafarM, UllahR, MahmoodHM, ParveenB, et al. An ethnobotanical study of medicinal plants used to treat skin diseases in northern Pakistan. BMC Compl Alt Med. 2019;19:210. doi: 10.1186/s12906-019-2605-6
60.
JoshiDR, KunwarRM, PokharelYR, BhattMD. Ecology and ethnobotany in and around Api Nampa Conservation Area (ANCA), Darchula, Nepal. Ethnobot Res Appl. 2021;22:1–13.
61.
ShahzadiN, KhanT, AliS. An allometric growth estimation and ethnobotanical studies of Hippophae rhamnoides substurkestanica from Oshikhandas and Bagrot valleys of district Gilgit, Gilgit-Baltistan, Pakistan. Nat Sci. 2021;19(6):26–8. doi: 10.7537/marsnsj190621.04
62.
ChandraS, ZafarR, DwivediP, ShindeLP, PritaB. Pharmacological and nutritional importance of Sea buckthorn (Hippophae). Pharm Innov J. 2018;7(5):258–63.
63.
GaoX, OhlanderM, JeppssonN, BjörkL, TrajkovskiV. Changes in antioxidant effects and their relationship to phytonutrients in fruits of Sea buckthorn (Hippophae rhamnoides L.) during maturation. J Agric Food Chem. 2000;48(5):1485–90. doi: 10.1021/jf991072g
64.
SoodSK, NathR, KaliaDC. Ethnobotany of cold desert tribes of Lahaul-Spiti (N.W. Himalaya). Deep publication, New Delhi, India, 2001.
65.
PengfeiL, TianshengD, XianglinH, JianguoW. Antioxidant properties of isolated isorhamnetin from the Sea buckthorn marc. Pl Foods Hum Nutr. 2009;64(2):141–5. doi: 10.1007/s11130-009-0116-1
66.
CristeA, UrcanAC, BuneaA, Pripon FurtunaFR, OlahNK, et al. Phytochemical composition and biological activity of berries and leaves from four Romanian Sea buckthorn (Hippophae rhamnoides L.) varieties. Molecules. 2020;25(5):1170. doi: 10.3390/molecules25051170
67.
SytarováI, OrsavováJ, SnopekL, MlçekJ, ByczyńskiŁ, MisurcováL. Impact of phenoliccompounds and vitamins C and E on antioxidant activity of Seabuckthorn (Hippophaë rhamnoides L.) berries andleaves of diverse ripening times. Food Chem. 2020;310:125784. doi: 10.1016/j.foodchem.2019.125784
68.
LiY, LiP, YangKL, HeQ, WangY, SunY, et al. Impact of drying methods on phenolic components and antioxidant activity of Sea buckthorn (Hippophae rhamnoides L.) berries from different varieties in China. Molecules. 2021;26(23):7189. doi: 10.3390/molecules2623718
69.
MihalceaL, TurturicaM, CucoleaEI, DanilăGM, DumitrascuL, ComanG, et al. CO2 supercritical fluid extraction of oleoresins from Sea buckthorn Pomace: Evidence of advanced bioactive profile and selected functionality. Antioxidants. 2021;10(11):1681. doi: 10.3390/antiox10111681
70.
PapN, ReshamwalaD, KorpinenR, KilpeläinenP, FidelisM, FurtadoMM, et al. Scots pine and Norway spruce extracts under a green integrated approach. Food Chem Toxicol. 2021;153:Article112284. doi: 10.1016/j.fct.2021.112284
71.
TkaczK, Gil-IzquierdoÁ, MedinaS, TurkiewiczIP, Domínguez-PerlesR, NowickaP, et al. Phytoprostanes,phytofurans, tocopherols, tocotrienols, carotenoids and free aminoacids and biological potential of Sea buckthorn juices. J Sci FoodAgric. 2022;102(1):185–97. doi: 10.1002/jsfa.11345
72.
WeiJ, LiS, SuT, ZhaoZ, JiangY, ZubarevYA, et al. Phenolic compositions and antioxidant activities of Hippophae tibetana and H.rhamnoides sssinensis berries produced in Qinghai-Tibet Plateau. Food Chem: X. 2022;15:100397. doi: 10.1016/j.fochx.2022.100397
73.
WaniTA, WaniSM, AhmadM, AhmadM, GaniA, MasoodiFA. Bioactive profile, health benefits and safety evaluation of Sea buckthorn (Hippophae rhamnoides L.): A review. Cogent Food and Agric. 2016;2(1):1128519. doi: 10.1080/23311932.2015.1128519
74.
ZhengWH, BaiHY, HanS, BaoF, ZhangK, SunL. Analysis on the constituents of branches, berries, and leaves of Hippophae rhamnoides L. by UHPLC-ESI-QTOF-MS and their anti-inflammatory activities. Nat Prod Comm. 2019;1-10. doi: 10.1177/1934578X19871404
75.
RehmanA, HussainS, JavedM, AliZ, RehmanH, ShahzadyTG, et al. Chemical composition andremedial perspectives of Hippophae rhamnoides Linn. Post Biol Komor. 2018;45(3):199–209.
76.
LiuS, XiaoP, KuangY, HaoJ, HuangT, LiuE. Flavonoids from Sea buckthorn: A review on phytochemistry, pharmacokinetics and role in metabolic diseases. J Food Biochem. 2021;45:e13724. doi: 10.1111/jfbc.13724
RastogiRP, MehrotraBN. Compendium of Indian medicinal plants, vols. 1–3. Central drug research institute, Lucknowand publications and information directorate, CSIR, New Delhi, pp. 1960-84.
79.
SabirSM, KhaliqA, MasoodH, TahirMK, KhanMQ. Phytochemical study of Sea buckthorn (Hippophae rhamnoides spp turkestanica) berries from Pakistan. Aust J Med Herbal. 2005;7(1):9–13.
80.
ArimboorR, VenugopalanVV, SarinkumarK, ArumughanC, SawhneyRC. Integrated processing of fresh Indian Sea buckthorn (Hippophae rhamnoides) berries and chemical evaluation of products. J Sci Food Agric. 2006;86(14):2345–235.
81.
RanjithA, KumarKS, VenugopalanVV, ArumughanC, SawhneyRC, SinghV. Fatty acids, tocols, and carotenoids in pulp oil of three Sea Buckthorn species (Hippophae rhamnoides, H.salicifolia, and H. tibetana) grown in the Indian Himalayas. J Amer Oil Chem’ Soc. 2006;83:359–64. doi: 10.1007/s11746-006-1213-z
HeinaahoM, HagermanAE, Julkunen-TiittoR. Effect of different organic farming methods on the phenolic composition of Sea buckthorn berries. J Agric Food Chem. 2009;57(5):1940–7. doi: 10.1021/jf802797v
84.
ChamanS, SyedNI, DanishZ, KhanFZ. Phytochemical analysis, antioxidant and antibacterial effects of Sea buckthorn berries. Pak J Pharmac Sci. 2011;24(3):345–51.
85.
KimJ, KwonY, SaY, KimM. Isolation and identification of Sea buckthorn (Hippophae rhamnoides) phenolics with antioxidant activity and α-glucosidase inhibitory effect. 2011;59(1):138–44. doi.org/10.1021/jf103130a
86.
KorekarG, StobdanT, SinghH, ChaurasiaOP, SinghSB. Phenolic content and antioxidant capacity of various solvent extracts from seabuckthorn (Hippophae rhamnoides L.) fruit pulp, seeds, leaves and stem bark. Acta Aliment. 2011;40(4):449–58. doi: 10.1556/AAlim.40.2011.4.4
87.
KumarMSY, DuttaR, PrasadD, MisraK. Subcritical water extraction of antioxidant compounds from Sea buckthorn (Hippophae rhamnoides) leaves for the comparative evaluation of antioxidant activity. Food Chem. 2011;127(3):1309–16. doi: 10.1016/j.foodchem.2011.01.088
88.
AroraR, MundraS, YadavA, SrivastavaRB, StobdanT. Antimicrobial activity of seed, pomace and leaf extracts of Sea buckthorn (Hippophae rhamnoides L.) against foodborne and food spoilage pathogens. Afr J Biotechnol. 2012;11(45):10424–30.
89.
FatimaT, SnyderCL, SchroederWR, CramD, DatlaR, WishartD, et al. Fatty acid composition of developing Sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. PloS One. 2012;7(4):e34099. doi: 10.1371/journal.pone.0034099
90.
GiuffridaD, PinteaA, DugoP, TorreG, PopRM, MondelloL. Determination of carotenoids and their esters in fruits of Sea buckthorn (Hippophae rhamnoides L.) by HPLC-DAD-APCI-MS. Phytochem Anal. 2012;23:267–73. doi: 10.1002/pca.1353
91.
MichelT, DestandauE, Le FlochG, LucchesiME, ElfakirC. Antimicrobial, antioxidant and phytochemical investigations of sea buckthorn (Hippophaë rhamnoides L.) leaf, stem, root and seed. Food Chem. 2012;131(3):754–60. doi: 10.1016/j.foodchem.2011.09.029
92.
KruczekM, SwiderskiA, Mech-NowakA, KrólK. Antioxidant capacity of crude extracts containing carotenoids from the berries of various cultivars of Sea buckthorn (Hippophae rhamnoides L.). Acta Biochimica Polonica. 2012;59(1):135–7.
93.
AhmadB, AliJ. Physiochemical, minerals, phytochemical contents, antimicrobial activities evaluation and fourier transform infrared (FTIR) analysis of Hippophae rhamnoides L.leaves extracts. Afr J Pharmacy and Pharmacol. 2013;7(7):375–88.
94.
ChenC, XuXM, ChenY, YuMY, WenFY, ZhangH. Identification, quantification and antioxidant activity of acylated flavonol glycosides from Sea buckthorn (Hippophae rhamnoides sssinensis). Food Chem. 2013;141(3):1573–9. doi: 10.1016/j.foodchem.2013.03.092
95.
GuptaD, KaulV. Qualitative analysis of bioactive compounds in leaves of Hippophae rhamnoides L. Nat Acad Sci Lett. 2013;36:477–81. doi: 10.1007/s40009-013-0160-0
96.
HussainM, AliS, AwanS, HussainM, HussainI. Analysis of minerals and vitamins in Sea buckthorn (Hippophae rhamnoids) pulp collected from Ghizer and Skardu districts of Gilgit-Baltistan. Int J Biosci. 2014;4(12):144–52. doi: 10.12692/ijb/4.12.144-152
97.
KorekarG, DolkarP, SinghH, SrivastavaRB, StobdanT. Variability and the genotypic effect on antioxidant activity, total phenolics, carotenoids and ascorbic acid content in seventeen natural population of Sea buckthorn (Hippophae rhamnoides L.) from trans-Himalaya. LWT - Food Sci Technol. 2014;55:157e162. doi: 10.1016/j.lwt.2013.09.006
98.
TeleszkoM, WojdyłoA, RudzińskaM, OszmiańskiJ, GolisT. Analysis of lipophilic and hydrophilic bioactive compounds content in Sea buckthorn (Hippophaë rhamnoides L.) berries. J Agric Food Chem. 2015;63(16):4120–9. doi: 10.1021/acs.jafc.5b00564
99.
ZebA, UllahS. Sea buckthorn seed oil protects against the oxidative stress produced by thermally oxidized lipids. Food Chem. 2015;186:6–12. doi: 10.1016/j.foodchem.2015.03.053
100.
QadirMI, AbbasK, YounusA, ShaikhRS. Antibacterial activity of Sea buckthorn (Hippophae rhamnoides L.) against methicillin resistant Staphylococcus aureus (MRSA). Pak J Pharmac Sci. 2016;29(5):1705–7.
101.
DolkarP, DolkarD, AngmoS, KumarB, StobdanT. Variability in phenolics, flavonoids and antioxidants in Seabuckthorn (Hippophae rhamnoides L.) seed from nine trans-Himalayan natural population. J Berry Res. 2017;7:109–16. doi: 10.3233/JBR-170149
102.
GuoR, GuoX, LiT, FuX, LiuRH. Comparative assessment of phytochemical profiles, antioxidant and antiproliferative activities of Sea buckthorn (Hippophae rhamnoides L.) berries. Food Chem. 2017;221:997–1003. doi: 10.1016/j.foodchem.2016.11.063
103.
GuptaD, KaulV. Antioxidant activity vis-a-vis phenolic content in leaves of sea buckthorn from Kargil District (J&K, India): A preliminary study. Nat Acad Sci Lett. 2016;40(1):53–6. doi: 10.1007/s40009-016-0510-9
104.
YueXF, ShangX, ZhangZJ, ZhangYN. Phytochemical composition and antibacterial activity of the essential oils from different parts of sea buckthorn (Hippophae rhamnoides L.). J Food Drug Anal. 2017;25(2):327–32. doi: 10.1016/j.jfda.2016.10.010
105.
ZhaoL, WenE, UpurH, TianS. High performance liquid chromatography-diode array detector method for the simultaneous determination of five compounds in the pulp and seed of Sea buckthorn. Pharmacog Mag. 2017;13(49):136–40. doi: 10.4103/0973-1296.197656
106.
LeleV, MonstaviciuteE, VarinauskaiteI, PeckaityteG, PaskeviciuteL, PlytnikaiteM, et al. Sea buckthorn (Hippophae rhamnoides L. ) and Quince (Cydonia oblonga L.) juices and their by-products as ingredients showing antimicrobial and antioxidant properties for chewing candy: Nutraceutical formulations. J Food Qual. 8. Article ID 202. 2018;8. Article ID 3474202. doi: 10.1155/2018/3474202
107.
IvanisováE, BlaskováM, TerentjevaM, GrygorievaO, VergunO, BrindzaJ, et al. Biological properties of Sea buckthorn(Hippophae rhamnoides L.) derived products. Acta ScientPolon. 2020;19(2):195–205. doi: 10.17306/J.AFS.0809
108.
SeglinaD, KrasnovaI, GrygierA, Radziejewska-KubzdelaE, RudzińskaM, GórnaśP. Unique bioactive moleculecomposition of Sea buckthorn (Hippophae rhamnoides L.) oilsobtained from the peel, pulp, and seeds via physical“solvent-free” approaches. J Amer Oil Chem Soc. 2021;98:1009–20. doi: 10.1002/aocs.12524
109.
ZhuY, YuenM, LiW, YuenH, WangM, SmithD, PengQ. Composition analysis and antioxidant activity evaluation of a high purity oligomeric procyanidin prepared from Sea buckthorn by a green method. Curr Res Food Sci. 2021;4:840–51. doi: 10.1016/j.crfs.2021.11.008
110.
BaseraIA, Verma, BhattVP, ShahMB. Determination of dioecy in Hippophae salicifolia by evaluating gallic acid content through a validated HPTLC method. J Appl Pharmac Sci. 2022;12(03):082–6. doi: 10.7324/JAPS.2022.120308
111.
HussainA. A preliminary up-to-date review on Pakistani medicinal plants with potential antioxidant activity. RADS J Biol Res Appl Sci. 2020;11(1):61–88.
112.
LaiLS, ChouST, ChaoWW. Studies on the antioxidative activities of Hsian-tsao (Mesona procumbens Hemsl) leaf gum. J Agric Food Chem. 2001;49:963–8. doi: 10.1021/jf001146k
113.
PapucC, DiaconescuC, NicorescuV. Antioxidant activity of Sea buckthorn (Hippophae Rhamnoides) extracts compared with common food additives. Roman Biotech Lett. 2008;13(6):4049–53.
114.
JeongJH, LeeJW, KimKS, KimJS, HanSN, YuCY, et al. Antioxidant and antimicrobial activities of extracts from a medicinal plant, Sea buckthorn. J Kor Soc Appl Biol Chem. 2010;53(1):33–8. doi: 10.3839/jksabc.2010.006
115.
AlexandrakisZ, KyriakopoulouK, KatsarosG, KrokidaM, TaoukisP. Selection of process conditions for high pressure pasteurization of Sea buckthorn juice retaining high antioxidant activity. Food Biopro Technol. 2014;7(11):3226–34. doi: 10.1007/s11947-014-1299-5
116.
NazirF, SalimR, BashirM. Chemical and antioxidant properties of Sea buckthorn (Hippophae rhamnoides). Pharma Innov J. 2017;6(12):173–6.
117.
TkaczK, WojdyłoA, TurkiewiczIP, BobakŁ, NowickaP. Anti-oxidant and anti-enzymatic activities of Sea buckthorn(Hippophaë rhamnoides L.) fruits modulated bychemical components. Antioxidants (Basel). 2019;8(12):618. doi: 10.3390/antiox8120618
118.
ZhengH, MaoL, YangJ, ZhangC, MiaoS, GaoY. Effect of oil content and emulsifier type on the properties and antioxidant activity of Sea buckthorn oil-in-water emulsions. J Food Qual. 2020. Article ID 1540925. doi: 10.1155/2020/1540925
119.
Puupponen-PimiäR, NohynekL, MeierC, KähkönenM, HeinonenM, HopiaA, et al. Antimicrobial properties of phenolic compounds from berries. J Appl Microbiol. 2001;90(4):494–507. doi: 10.1046/j.1365-2672.2001.01271.x
120.
GuptaSM, GuptaAK, AhmedZ, KumarA. Sea buckthorn (Hippophae L.): A multipurpose wonder plant, Vol. 4: Emerging trends in research and technologies (Virendra Singh, Editor-in-Chief, 2014), Daya Publishing House, New Delhi, India; 2014, pp. 393-401.
121.
SaimaWMK, IqbalA, ShumailH, KhalidS, AkhtarN, GhaffarN, et al. Antimicrobial activities of different solvent extracted sample of Hippophae rhamnoides L. (Sea Buckthorn). Pure and Appl Biol (PAB). 2021;1(1):259–70.
122.
SandulachiE, MacariA, CojocariD, BalanG, PopaS, TurculetN, et al. Antimicrobial properties of Sea buckthorn grown in the Republic of Moldova. J Engin Sci. 2022;(1):164–75. doi: 10.52326/jes.utm.2022.29(1).15
123.
GuptaSM, GuptaAK, AhmedZ, KumarA. Antibacterial and antifungal activity in leaf, seed extract and seed oil of Sea buckthorn (Hippophae salicifolia D. Don) Plant. J Pl Pathol Microbiol. 2011;2:105. doi: 10.4172/2157-7471.1000105
124.
DaenaroM, SmeriglioA, Clara De FrancescoB, OccutiutoC, MilanoG, et al. Antiviral activity of plants and their isolated bioactive compounds: An update. Phytother Res. 2020;34(4):742–68. doi: 10.1002/ptr.6575
125.
LarmoP, AlinJ, SalminenE, KallioH, TahvonenR. Effects of sea buckthorn berries on infections and inflammations: A double-bind, randomized, placebo-controlled trial. Europ J Clin Nutr. 2008;62(9):1123–30. doi: 10.1038/sj.ejcn.1602831
126.
ShipulinaLA. Some new data about antiviral and related activities of Sea buckthorn principals and the prospects of their use. All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, 2013.
127.
TorelliA, GianchecchiE, ManentiA, PicciniG, Lorente PastorE, et al. Sea buckthorn bud extract displays activity against cell-cultured influenza virus. J. Preven Meas Hyg. 2015;56(2):E51–6.
128.
KrejcarovaJ, StrakovaE, SuchyP, HerzigI. Sea buckthorn (Hippophae rhamnoides L.) as a potential source of nutraceuticals and its therapeutic possibilities- a review. Acta Vet Brno. 2015;84:257–68. doi: 10.2754/AVB201584030257
129.
EnkhtaivanG, JohnKM, PanduranganM, HurJH, LeutouAS, et al. Extreme effects of Seabuckthorn extracts on influenza viruses and human cancer cells and correlation between flavonol glycosides and biological activities of extracts. Saudi J Biol Sci. 2017;24:1646–56. doi: 10.1016/j.sjbs.2016.01.004
130.
SinghD, JayashankarB, MishraKP, TanwarH, MadhusudanaSN, BelludiAY, et al. Adjuvant activity of ethanol extract of Hippophae rhamnoids leaves with inactivated rabies virus antigen. Pharm Biol. 2018;56(1):25–31. doi;10.1080/13880209.2017.1413662
131.
PourPM, FakhriS, AsgaryS, MuhammadiHF, EcheverriJ. The signaling pathways, and therapeutic targets of antiviral agents: Focusing on the antiviral approaches and clinical perspective of anthocyanins in the management of viral disease. Front Pharmacol. 2019. doi: 10.3389/fphar.2019.01207
132.
RédeiD, KúszN, RafaiT, BogdanovA, BuriánK, CsorbaA, et al. 14-Noreudesmanes and a phenylpropane heterodimer from Seabuckthorn berry inhibit Herpes simplex type 2 virus replication. Tetrahedron. 2019;71(10):1364–70. doi: 10.1016/j.tet.2019.01.050
133.
ZhanY, TaW, TangW, HuaR, WangJ, WangC, et al. Potential antiviral activity of isohemnetin against SARS-CoV-2 spike pseudotyped virus in vitro. J Drug Devel Res. 2020;1-7. doi: 10.1002/ddr.21815
134.
JainM, GanjuL, KatiyalA, PadwadY, MishraKP, ChandaS, et al. Effect of Hippophae rhamnoides leaf extract against Dengue virus infection in human blood-derived macrophages. Phytomedicine. 2008;15(10):793–9. doi: 10.1016/j.phymed.2008.04.017
135.
SiegelRL, MillerKD, FuchsHE, JemalA. Cancer statistics. CA Cancer J Clin. 2022;72(1):7–33. doi: 10.3322/caac.21708
136.
CosteaT, HuditaA, CiolacOA, GalateanuB, GinghinaO, CostacheM, et al. Chemoprevention of colorectal cancer by dietary compounds. Int J Mol Sci. 2018;19:3787. doi: 10.3390/ijms19123787
137.
PatelCA, DivakarK, SantaniD, SolankiHK, ThakkarJH. Remedial prospective of Hippophae rhamnoides Linn. (Sea buckthorn). Int Schol Res Not. 2012;436857. doi: 10.5402/2012/436857
138.
LiC, YangX, ChenC, CaiS, HuJ. Isorhamnetin suppresses colon cancer cell growth through the PI3K-Akt-Mtor pathway. Mol Med Rep. 2014;9(3):935–40. doi: 10.3892/mmr.2014.1886
139.
WangY, NieF, OuyangJ, WangX, MaX. Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells. Tum Boil. 2014;35(10):9563–9. doi: 10.1007/s13277-014-2233-1
140.
AliJ, AhmadB. Comparative antitumor and anti-proliferative activities of Hippophae rhamnoides L.leaves extracts. J Coast Life Med. 2015;3(3):228–32.
141.
ChakrabortyM, KarmakarI, HaldarS, NepalA, HaldarPK. Anticancer and antioxidant activity of methanol extract of Hippophae salicifolia in EAC induced swiss albino mice. Int J Pharm Pharm Sci. 2015;7:180–4.
142.
WangH, GaoT, DuY, YangH, WeiL, BiH, et al. Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L.berry. Carb Poly. 2015;131:288–96. doi: 10.1016/j.carbpol.2015.06.021
143.
OppermannC, EngelN, RuthW, NebeB, KraglU. LC-MS analysis of extracts from beech and Sea buckthorn to correlate the phytoestrogen content and anti-cancer activity. J Chem Pharm Res. 2015;7(5):175–85.
144.
BatboldU, LiuJJ. Chemosensitization effect of Sea buckthorn (Hippophae rhamnoides L.) pulp oil via autophagy and senescence in NSCLC Cells. Foods. 2022;11:1517. doi: 10.3390/foods11101517
145.
KimSJ, HwangE, YiSS, SongKD, LeeHK, HeoT, et al. Sea buckthorn leaf extract inhibits glioma cell growth by reducing reactive oxygen species and promoting apoptosis. Appl Biochem Biotech. 2017;182(4):1663–74. doi: 10.1007/s12010-017-2425-4
146.
WeiJ, SuH, BiY, LiJ, FengL, ShengW. Anti-proliferative effect of isorhamnetin on HeLa cells through inducing G2/M cell cycle arrest. Exp Ther Med. 2018;15(4):3917–23. doi: 10.3892/etm.2018.5892
147.
AliI, ZahraNUA, SharifHMM, BhattiHAA. new potent anti-cancer corosolic ester identified from the super miracle plant Hippophae rhamnoides (Sea buckthorn). Biochem Mod Appl. 2019;2(1):24–9. doi: 10.33805/2638-7735.119
148.
MasoodiKZ, WaniW, DarZA, MansoorS, Anam-ul-HaqS, FarooqI, et al. Sea buckthorn (Hippophae rhamnoides L.) inhibits cellular proliferation, wound healing and decreases expression of prostate specific antigen in prostate cancer cells in vitro. J Funct Foods. 2020;73:104102. doi: 10.1016/j.jff.2020.104102
149.
DudauM, VilceanuAC, CodriciE, MihaiS, PopescuID, AlbulescuL, et al. Sea-buckthorn seed oil induces proliferation of both normal and dysplastic keratinocytes in basal conditions and under UVA irradiation. J Person Med. 2021;11(4):278. doi: 10.3390/jpm11040278
150.
MarciniakB, KontekR, ZuchowskiJ, StochmalA. Novel bioactive properties of low-polarity fractions from Sea-buckthorn extracts (Elaeagnus rhamnoides (L.) A. Nelson) –(in vitro). Biomed Pharmacotheer. 2021;135:111141. doi: 10.1016/j.biopha.2020.111141
151.
JuszczakM, KluskaM, SkalskiB, ZuchowskiJ, StochmalA, OlasB. et alMultidirectional effects of saponin fraction isolated from the leaves of Sea buckthorn Elaeagnus rhamnoides (L.) A. Nelson. Biomed Pharmacother. 2021;137:111395. doi: 10.1016/j.biopha.2021.111395
152.
KoskovacM, CuparaS, KipicM, BarjaktarevicA, MilovanovicO, KojicicK, et al. Sea buckthorn oil—a valuable source for cosmeceuticals. Cosmetics. 2017;4(4):40. doi.org/10.3390/cosmetics4040040
153.
ZielinskaA, NowakI. Fatty acids in vegetable oils and their importance in cosmetic industry. Chem Aust. 2014;68:103–10.
154.
YenCH, DaiYS, YangYH, LeeJH, ChiangBL. Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. Ann Allergy Asthma Immunol. 2008;100:66–73.
155.
AkhtarN, KhanBA, MahmoodT, ParveenR, QayumM, AnwarM, et al. Formulation and evaluation of antisebum secretion effects of Sea buckthorn w/o emulsion. J Pharm Bioallied Sci. 2010;2(1):13–7. doi: 10.4103/0975-7406.62698
156.
DudauM, CodriciE, TarcomnicuI, MihaiS, PopescuID, AlbulescuL, et al. A fatty acid fraction purified from Sea buckthorn seed oil has regenerative properties on normal skin cells. Front Pharmacol. 2021;12:737571. doi: 10.3389/fphar.2021.737571
157.
WeimannE, SilvaMBB, MurataGM, BortolonJR, DermargosA, CuriR, et al. Topical anti-inflammatory activity of palmitoleic acid improves wound healing. PLoS On. 2018;13:e0205338. doi: 10.1371/journal.pone.0205338
ZielinskaA, NowakI. Fatty acids in vegetable oils and their importance in cosmetic industry. Chem Aust. 2014;68:103–10.
160.
HwangIS, KimJE, ChoiSI, LeeHR, LeeYJ, JangMJ, et al. UV radiation-induced skin aging in hairless mice is effectively prevented by oral intake of sea buckthorn (Hippophae rhamnoides L.) fruit blend for 6 weeks through MMP suppression and increase of SOD activity. Int J Mol Med. 2012;30(2):392–400. doi: 10.3892/ijmm.2012.1011
161.
KoraćRR, KhambholjaKM. Potential of herbs in skin protectionfrom ultraviolet radiation. Pharmacogn Rev. 2011;5(10):164–73. doi: 10.4103/0973-7847.91114
162.
KhanBA, AkhtarN, MahmoodT, KhanHMS, Shahiq-Uz Zaman, RasuA. In-vivo study of stratum corneum water content and transepideramal water loss using a newly formulated topical cream of hippophae rhamnoides fruit extract. Afr J Pharm Pharmacol. 2011;5(8):1092–5.
