Localization of current dipole by minimizing entropy of dipole distribution for magnetoencephalography

Abstract

A method to reconstruct the current dipoles in human brain for magnetoencephalography was examined. In the method, a spatial filter provided the initial guess of the current dipole distribution. Then the current dipoles were localized by minimized the entropy calculated with the current dipole distribution. The reconstructed dipole moments were corrected in a post processing. In the numerical simulations the proposed method was compared with the focal underdetermined system solver (FOCUSS) which reconstructed a sparse distribution of the current dipoles. The proposed method was able to reconstruct the current dipoles more robustly than FOCUSS from the measured magnetic fluxes with low signal-to-noise ratio.