The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio® XT Patch. The associations between global cortical Aβ (> 1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.
DienerH, HartRG, KoudstaalPJ, LaneDA, LipGY (2019) Atrial fibrillation and cognitive function: JACC review topic of the week. J Am Coll Cardiol73, 612–619.
2.
AldrughS, SardanaM, HenningerN, SaczynskiJS, Mc-ManusDD (2017) Atrial fibrillation, cognition and demen-tia: A review. J Cardiovasc Electrophysiol28, 958–965.
3.
ChenLY, ChungMK, AllenLA, EzekowitzM, FurieKL, McCabeP, NoseworthyPA, PerezMV, TurakhiaMP; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Stroke Council (2018) Atrial fibrillation burden: Moving beyond atrial fibrillation as a binary entity: A scientific statement from the American Heart Association. Circulation137, e623.
4.
RooneyMR, NorbyFL, MaheshwariA, LutseyPL, DudleySCJr, SolimanEZ, LoehrLR, MosleyTH, CoreshJ, AlonsoA, ChenLY (2021) Frequent premature atrial contractions are associated with poorer cognitive function in the Atherosclerosis Risk in Communities (ARIC) Study. Mayo Clin Proc96, 1147–1156.
5.
HimmelreichJCL, LucassenWAM, HeugenM, BossuytPMM, TanHL, HarskampRE, van Etten-JamaludinFS, van WeertHCPM (2019) Frequent premature atrial contractions are associated with atrial fibrillation, brain ischaemia, and mortality: A systematic review and meta-analysis. Europace21, 698–707.
6.
MurphyMP, CorriveauRA, WilcockDM (2016) Vascular contributions to cognitive impairment and dementia (VCID). Biochim Biophys Acta1862, 857.
7.
The Atherosclerosis Risk in Communities (ARIC) Study: Design and objectives. The ARIC investigators. (1989), Am J Epidemiol129, 687–702.
8.
GottesmanRF, AlbertMS, AlonsoA, CokerLH, CoreshJ, DavisSM, DealJA, McKhannGM, MosleyTH, SharrettAR, SchneiderALC, WindhamBG, WruckLM, KnopmanDS (2017) Associations between midlife vascular risk factors and 25-year incident dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort. JAMA Neurol74, 1246–1254.
9.
RooneyMR, SolimanEZ, LutseyPL, NorbyFL, LoehrLR, MosleyTH, ZhangM, GottesmanRF, CoreshJ, FolsomAR (2019) Prevalence and characteristics of subclinical atrial fibrillation in a community-dwelling elderly population: The ARIC Study. Circ Arrhythm Electrophysiol12, e007390.
10.
AlonsoA, AgarwalSK, SolimanEZ, AmbroseM, ChamberlainAM, PrineasRJ, FolsomAR (2009) Incidence of atrial fibrillation in whites and African-Americans: The Atherosclerosis Risk in Communities (ARIC) study. Am Heart J158, 111–117.
11.
GottesmanRF, SchneiderAL, ZhouY, ChenX, GreenE, GuptaN, KnopmanDS, MintzA, RahmimA, SharrettAR, WagenknechtLE, WongDF, MosleyTHJr (2016) The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE. Neurology87, 473–480.
12.
OttA, BretelerMM, de BruyneMC, van HarskampF, GrobbeeDE, HofmanA (1997) Atrial fibrillation and dementia in a population-based study: The Rotterdam Study. Stroke28, 316–321.
13.
de BruijnRF, HeeringaJ, WoltersFJ, FrancoOH, StrickerBH, HofmanA, KoudstaalPJ, IkramMA (2015) Association between atrial fibrillation and dementia in the general population. JAMA Neurol72, 1288–1294.
