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Abstract

Background:

Cognitive decline is influenced by various factors including diet, cardiovascular disease, and glucose control. However, the combined effect of these risk factors on cognitive performance is yet to be fully understood.

Objective:

The current study aimed to explore the inter-relationship between these risk factors and cognitive performance in older adults at risk of future cognitive decline.

Methods:

The sample comprised 163 (Age: M = 65.23 years, SD = 6.50) participants. Food Frequency Questionnaire data was used to score diet quality and adherence to the Western Style Diet (WSD) and Prudent Style Diet (PSD). Glucose control was gauged by serum levels of glycated hemoglobin (HbA1c) and arterial stiffness was measured using carotid to femoral pulse wave velocity. Cognitive performance was assessed using two subtests of the Swinburne University Computerized Cognitive Assessment Battery (SUCCAB) and Rey’s Verbal Learning Test (RVLT).

Results:

Diet quality, adherence to the WSD or PSD, and glucose control were not significantly related to cognitive outcomes. However, a significant negative association was found between arterial stiffness and the spatial working memory subtest of SUCCAB (β= –0.21, p < 0.05). Arterial stiffness also significantly interacted with the PSD to impact total recall (F change (1,134) = 5.37, p < 0.05) and the composite score of RVLT (F change (1,134) = 4.03, p < 0.05).

Conclusion:

In this sample of older adults at risk of cognitive decline, diet alone was not found to predict cognitive performance; however, it was found to moderate the relationship between arterial stiffness and cognition.

Keywords

Aging arterial stiffness cognition diet dietary patterns glucose control working memory

INTRODUCTION

The growing number of elderly people [1] has resulted in increasing numbers of people living with age-related diseases such as dementia, cardiovascular disease, and metabolic syndrome [2 –5]. However, the development of such non-communicable disorders is not an inevitable part of senescence. Increasing research suggests that modifiable lifestyle factors such as diet can delay the onset and progression of age-related diseases [6 –9].

At a population level, aging is associated with a decline in cognitive abilities. However, the extent of cognitive decline is subject to wide interindividual variation [10, 11]. Some individuals reach old age with their cognitive abilities relatively intact while others develop cognitive aging disorders such as Alzheimer’s disease (AD). The development of AD has a long preclinical stage where the biological markers of the disease are present for years, possibly decades, before diagnosis [12, 13]. As there are no effective treatments once a clinical diagnosis is reached, evidence suggests targeting the preclinical stage with intervention strategies may be a more effective strategy to combat AD [12].

Diet has been proposed as a possible intervention strategy during the preclinical stages of AD as it has been linked to many aspects of health including cognitive performance. Research has shown that ‘healthy diets’ assessed using measures of diet quality or adherence to dietary patterns, such as the Mediterranean diet, Dietary Approaches to Stop Hypertension (DASH) diet, the Mediterranean-DASH diet intervention for neurodegenerative delay, (MIND) diet, and prudent style diet (PSD), have been associated with reduced risk of cognitive decline [14 –19] and improved cognitive performance after dietary intervention [20 –22]. However, Australians predominantly do not adhere to these healthy dietary patterns. On average, Australians are exceeding recommendations for discretionary food and only 4%are meeting the recommended daily intake of vegetables and legumes [23, 24]. This suggests that the typical Australian diet is more consistent with a Western Style Diet (WSD), which comprises a high intake of processed foods, red meat, processed meats, saturated fat, full-fat dairy, alcohol and refined sugars; reduced consumption of complex carbohydrates, fiber intake, fruit and vegetables [25, 26]. Even though adherence to the WSD is increasing globally, research on how this dietary pattern affects cognitive performance is limited when compared to healthy dietary patterns [18 , 28]. However, adherence to the WSD and similar dietary patterns have been related to accelerated decline in visuospatial functioning [26] and poorer vocabulary and semantic fluency [29]. Another way to capture the complex nature of diet is to measure diet quality which assesses overall nutritional risk for future disease [30]. Poorer diet quality which is associated with the WSD has been found to be related to impaired cognition [31], while an optimal diet has been related to better cognitive processing [32].

Diet quality and adherence to various dietary patterns have also been related to cardiovascular health. For example, higher diet quality has been found to reduce the risk of cardiovascular disease [33, 34], whereas adherence to the WSD has been linked to increased risk of cardiovascular disease [35]. Cardiovascular function may be an important mechanisms underpinning the relationship between diet and cognition as it is also related to cognitive function [36, 37]. Arterial stiffness is a useful measure of cardiovascular health and function. During aging arterial walls change from a relatively ‘elastic’ to a more ‘inelastic’ state termed ‘arterial stiffness’. This results in an increase in pressure wave reflections that arrive back to the heart augmenting the aortic pressures [38, 39]. Higher arterial stiffness is associated with poorer cognitive performance, with higher predictive validity in comparison to other cardiovascular health markers such as brachial blood pressure [40, 41]. As arterial stiffness is a well establish risk factor for cognitive decline and is also related to diet [40], diet may be a moderating factor in the relationship between arterial stiffness and cognitive health.

Diet is also a possible moderating factor in the relationship between glucose control and cognitive health. As a hallmark of metabolic syndrome and diabetes, poor glucose control and insulin resistance have also been found to be related to worse cognitive performance and increased risk of dementia in both healthy individuals and those with diabetes [42 –46]. Specifically, increased glycated hemoglobin (HbA1c), a measure of glucose control over the preceding 8–12 weeks, has been related to declines in episodic memory in both people with and without diabetes [47], declines in the performance on the Mini-Mental State Examination (MMSE) in people without diabetes [48] and reduced hippocampal and frontal brain volumes in adolescents with diabetes [49]. The relationship of glucose control with both cognition and diet [50, 51] suggests that diet may also have a moderating effect on the relationship between glucose control and cognition.

The current body of evidence supports the link between diet and various cardio-metabolic risk factors with cognitive decline. However, little is known about the mechanisms underpinning diet and how it may interact with other risk factors to have a combined, perhaps even synergistic effect on cognition. The present study aimed to explore the relationship between diet (specifically diet quality and adherence to both the WSD and PSD) and cognitive performance in a non-clinical population of older adults at risk of cognitive decline [12, 52]. It is hypothesized that greater diet quality and adherence to PSD will be related to improved cognitive performance, whereas greater adherence to the WSD will be related to poorer cognitive performance. The study also aimed to explore whether glucose control and arterial stiffness are related to cognitive performance in a population free of diabetes and cardiovascular disease and whether diet moderates the relationships of glucose control and arterial stiffness with cognitive performance. However, the study was powered for at most one interaction and this was chosen to be the interaction between arterial stiffness and adherence to the PSD. While the literature supports possible interactions between diet and both measures of cardio metabolic risk. Arterial stiffness and PSD were chosen as the primary interaction to extend the work of Kennedy et al. (2018) [53], which explored how arterial stiffness and lifestyle factors impact cognition in a similar sample older Australian adults. All other interaction analyses were regarded as exploratory.

MATERIALS AND METHODS

The present study analyzed baseline data from an existing clinical trial: Phospholipid Intervention for Cognitive Aging Reversal (PLICAR) conducted at the Centre for Human Psychopharmacology at Swinburne University, Melbourne, Australia. This clinical trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12613000347763). The aim of the PLICAR trial was to investigate the effects of a dietary intervention on cognition and health in older individuals at risk of future cognitive decline, the results of which will be published elsewhere (for more details on the randomized controlled trial, see [54]). The present investigation is an exploratory cross-sectional examination of the relationship between diet, arterial stiffness, glucose control, and cognitive performance prior to administering the intervention. The study was approved by the Swinburne University Human Research Ethics Committee (SUHREC Project No. 2012/294).

Participants

There were 163 participants (M = 65.23 years, SD = 6.50) who completed testing for the study. They were recruited through the Centre for Human Psychopharmacology database of existing participants, community flyers, and internet advertisements. Interested participants were initially screened via telephone as a preliminary assessment of eligibility. Participants were excluded from the study if they were below 55 years of age, diagnosed with any neurological disorders, diabetes, heart disease, bleeding disorders, psychiatric illnesses, depression, or dementia. To assess risk of future cognitive decline, participants were also screened to ensure that they met Crook et al.’s [52] criteria for age associated memory impairment using the Verbal Paired Associates (VPA) test [55] and Memory Complaint Questionnaire [56]. A maximum score of 32 on the VPA was used to screen for objective memory impairment and a minimum score of 25 on the MAC-Q [56] was use to screen for subjective memory complaints. This ensured that participants had self-reported memory complaints and scored at least one standard deviation below the mean for memory as measured on the VPA, suggesting future risk of further cognitive decline.

The initial phone screening was conducted as a preliminary assessment of eligibility and discussion outlining what participation involved. If eligible following the telephone screen, the participant was scheduled for a practice session which included additional screening measures to finalize eligibility. It included written informed consent, the MMSE [57], and the Beck Depression Inventory-II (BDI-II) [58]. The session also allowed participants to familiarize themselves with the study procedures through a practice trial of computerized cognitive assessments (SUCCAB). Administration of the Food Frequency Questionnaire (FFQ) was also completed during the practice session. The baseline testing session was conducted on average 20.17 (±21.65) days after the practice session. Participants were asked to fast from 10 pm the night before and abstain from any alcohol (for 12 h prior to testing) and caffeinated beverages (on the day of testing). On arrival, a fasting blood sample was collected by a registered research nurse or a qualified venipuncture technician. The blood sample was then sent to a pathology laboratory for analysis of HbA1c levels. Following this, the participant was provided with a standard light breakfast followed by a 15 min break. During the testing session, participants completed the cognitive assessments (SUCCAB and RVLT). An outline of assessments is displayed in Fig. 1.

Fig. 1

Schedule of assessments from the PLICAR trial used in the current analysis.

Diet

To measure nutritional intake, the Food Frequency Questionnaire (FFQ) from the Cancer Council Victoria was used [59, 60]. This FFQ is a well validated and reliable measure of habitual dietary intake in an Australian population [61, 62]. It assesses frequency of consumption and average serving size of 74 different food items and six alcoholic beverages over the last 12 months. Estimations of daily intake for each food item were calculated in grams per day based on the reported portion size. Total energy (kJ) intake per day was computed based on the AUSNUT 2007 nutrient database [63].

Responses on the FFQ were used to score adherence to the Western Style Diet (WSD) and Prudent Style Diet (PSD), based on the method used by Gardener et al. [26]. This method was chosen as Gardener et al. used the same FFQ [59, 60] as the current study and it was conducted in a similar cohort of elderly Australian individuals. Supplementary Tables 1 and 2 outline the food items in each of the WSD and PSD factors developed by Gardener et al. Adherence was scored by multiplying consumption of each food group (grams per day) with its corresponding factor loading and adding these values together. A higher score indicates greater adherence to each respective dietary pattern [26].

In addition to scoring adherence to these two dietary patterns, overall diet quality was assessed using the Australian version of the Diet Screening Tool (DST) [30, 64]. The tool comprised twenty items and has a maximum score of 104, with a higher score reflecting better diet quality [30, 64]. It has recently been found to differentiate nutrient intake, blood nutrient status, mood, and cognition in Australian middle-aged adults [32]. Frequency data from the FFQ was used to score diet quality from the DST. As no frequency data was available for olive oil intake, this question was omitted, changing the overall maximum score to 99 (range: 0–99). As the DST is a validated measure of diet quality, Pearson’s correlations were conducted to demonstrate that both the WSD and PSD measure low and high diet quality respectably. The WSD was negatively correlated with DST (r = –0.392, p < 0.001), whereas the PSD was positively correlated with the DST (r = 0.437, p < 0.00).

Arterial stiffness assessment

Arterial stiffness was assessed using carotid-femoral pulse wave velocity (cf-PWV). This was measured using the SphygmoCor® device (Model XCEL, AtCor Medical, Sydney, Australia). Cf-PWV was calculated using a femoral cuff. This cuff measures the pressure pulse waveform from the femoral artery. While the participant was supine, the cuff was inflated to measuring the pulse pressure waveform from the femoral artery and the research assistant concurrently measured the carotid waveform using a pressure tonometer probe (placed on the participant’s neck/ carotid pulse). The distance between the two points (carotid & femoral) were measured to estimate the speed of the pressure pulse. cf-PWV is a well validated method and is considered the gold standard for non-invasive arterial stiffness assessment [65, 66]. For each participant two cf-PWV recordings were made, the recordings were then reviewed by SG and the recording with the lower standard deviation was selected for analysis. For participants with two cf-PWV recordings with the same standard deviation, the score was averaged.

Glucose control

Fasting hematological testing was conducted at the start of the visit to assess glucose control. Pre-processing was completed on site where possible, samples were then couriered to a commercial pathology laboratory for analysis. Glucose control was specifically measured using the blood marker glycated hemoglobin (HbA1c). As this measure reflects average blood glucose levels in the preceding 8 to 12 weeks [67], elevated HbA1c indicates poorer glucose control. Studies have suggested that glucose control should be measured and reported in the standardized International Federation of Clinical Chemistry and Laboratory Medicine units (IFCC) [68, 69]. Normal levels of HbA1c are defined as between 20–42 mmol/mol and levels above 46 mmol/mol are considered to be an indicator of diabetes [69].

Cognitive outcomes

Swinburne university computerized cognitive assessment battery (SUCCAB)

The SUCCAB is a well validated and reliable measure of cognitive functioning in older adults [70]. The full battery was designed to measure performance accuracy and response time across eight different measures of cognitive functioning. Contextual Memory (CM) and Spatial Working Memory (SWM) are two of the most sensitive tests of age-associated cognitive decline [70]. Both tasks are sensitive to change through dietary intervention [21 , 72]. The current study focused on the performance outcomes for these two tests. SWM measures the ability to hold spatial information in working memory whereas CM measures an aspect of contextual episodic memory for everyday objects [70].

Testing was conducted using a color computer monitor and responses were recorded using a standard keyboard with the keys A and L labelled to indicate yes/no responses respectively and the arrow keyboard buttons were also used. For both the SWM and CM tasks, written and verbal instructions were provided to participants as well as a practice trial to allow participants to familiarize themselves with the test and response method.

The SWM task of SUCCAB begins with the presentation of a 4 x 4 grid on the screen, with six random grid positions containing white squares for 3 s (see Fig. 2a). Following this, a series of single white squares are sequentially presented in different locations on the grid. Participants were required to respond ‘yes’ or ‘no’ on a labelled keyboard to indicate if they believe the single test square was in one of the locations of the original pattern (see Fig. 2b). Participants had 2 s to respond if they took longer, it was marked as incorrect.

Fig. 2

Spatial working memory task. a) The 4 x 4 grid on the screen contacting six random grid white squares. B) A single white square is presented in on the grid. Participants required to respond ‘yes’ or ‘no’ to indicate if square was in one of the locations of the original pattern.

During the CM task, participants were presented with a series of 20 colored images of everyday objects. These images were presented at different locations on the screen, either the top, bottom, left or right; each image was displayed for 3 s with no inter-stimulus interval (see Fig. 3a). Once the series of images were all presented, a second set of the same pictures were presented in the center of the screen and participants were required to indicate where the original image was located using the arrow keys on the keyboard (see Fig. 3b).

Fig. 3

Contextual memory. a) Example of an everyday object presented on the top of the screen. b) Example of the same everyday object presented in the second set, participants was required to indicate original located using the arrow keys on the keyboard.

The results from the correctly performed trials were averaged to provide an overall mean reaction time in milliseconds for each test. Response accuracy was calculated for both SWM and CM as the percentage of the correctly performed trials. Performance scores for both the SWM and CM subtests were calculated by dividing accuracy by reaction time with higher scores indicative of better performance.

Rey’s verbal learning test (RVLT)

In addition to the SUCCAB, RVLT was also used to assess cognitive performance. RVLT is a well validated and reliable test of verbal learning and memory [73, 74]. Measures of memory and verbal memory have been found to be sensitive to age associated cognitive decline and have been found to be sensitive to different dietary patterns and dietary intervention [75, 76].

During the RVLT test, the experimenter read a list of 15 words to the participant in a fixed sequence, with one word every 2 s. After the presentation of the sequence, participants were asked to recall as many of the words as they could. This immediate recall process was repeated five times and following this there was a 20 min delay during which participants completed other cognitive assessments. After the delay participants were asked to recall as many words as they could remember from the original list.

There were three performance scores for this measure: Total immediate recall was the summed total number of words recalled for the first five trials (scores ranged from 0–75). Maximum immediate recall was the highest number of words recalled during the first five trials (scores ranged from 0–15) and Delayed recall was the number of words recalled in the sixth trial (scores ranged from 0–15) [74, 77]. A memory composite score was also calculated using the same method as Durga et al., the z scores for each of the outcomes were added together and divided by three [77].

Data analyses

All data analyses were conducted using SPSS version 27. Demographic data were presented using the mean and standard deviation. All data used in the current analysis met assumptions for regression, so no transformation was needed. Z scores were calculated for each variable, scores greater than 3.29 or scores greatly disconnected from the spread of the data were considered outliers and excluded from subsequent analysis. A series of two stage hierarchical regressions were conducted with the covariates entered at stage one and the independent variables (PSD, WSD, DST, cf-PWV, and HbA1c) entered at stage two. Dependent variables were the performance outcomes for SUCCAB and RVLT. Covariates were age (in years), gender, years of education, energy intake (kJ), and body mass index (BMI; weight in kilograms/height in m²). These covariates have been found to be related to cognition in the past [53 , 78–83]. All the covariates except for gender were included in the model as continuous variables. Significance was set at a 5%level.

Following primary analyses, additional sequential multiple regression analyses were conducted to test for diet and cardio-metabolic risk interaction effects. Firstly, the dietary, glucose and, arterial stiffness measures were centered, allowing for interaction terms to be computed. The interaction terms were then computed by multiplying two centered variables together (e.g., for the interaction between PSD and arterial stiffness these two centered measures were multiplied together). For the multiple regressions, the covariates (age, gender, years of education, energy intake (kJ) and BMI) were entered at stage one, the two centered variables at stage two and the interaction term at stage three. Due to the small sample size only one of these interactions was tested for significance. A sample size estimation was conducted using G^*Power [84], finding that when using ten variables in a model (five covariates, five independent variables), a 1%significance level to allow for six cognition outcomes, an estimated effect size of f² = 0.15 and power of 0.80, a sample of 160 participants is required. In order to visualize the significant interactions, Cohen et al. (2003) suggest plotting the dependent variable at one standard deviation below the mean (low), at the mean (medium), and one standard deviation above the mean (high) for the predictor variables [85].

RESULTS

Means and standard deviations for the demographic variables and baseline measures for participants are presented in Table 1. Participants in the study had a mean age of 65.23 years, 46.6%of participants completed tertiary education, around half the participants were retired (49.7%) with only 20.3%still working full time. On average participant BMI was above the healthy range (M = 28.21, SD = 4.98), almost all participant had glucose control readings in the healthy range (HbA1c between 20–42 mmol/mol) and of arterial stiffness measures were within two standard deviations of the norms for this age range [66]. All cognitive outcomes were negatively correlated with age (p < 0.007).

Table 1

Summary of means and standard deviations for all variables

Variable	N	M	SD	Min	Max
Demographic
Age (y)	163	65.23	6.50	55.00	84.00
Years of Education	163	15.14	3.42	5.00	23.00
BMI (kg/m²)	162	28.21	4.98	18.00	46.11
Diet
WSD score	157	178.20	137.23	–76.93	629.75
PSD score	157	234.85	127.45	–165.27	560.04
DST	158	67.58	9.31	38.00	85.00
Energy (kJ)	157	7,220.36	2,255.77	3,367.35	10,795.40
Glucose control
HbA1c (mmol/mol)	153	37.03	3.66	28.00	46.00
Arterial Stiffness
cf-PWV (m/s)	149	10.71	1.75	6.00	15.6
Cognitive Variables
SUCCAB
CM Performance	162	67.83	17.30	27.58	113.19
SWM Performance	162	63.29	17.32	8.38	115.66
RVLT
Total immediate recall	163	46.88	9.14	19.00	67.00
Max immediate recall	163	11.89	2.13	5.00	15.00
Delayed recall	163	8.87	3.13	0.00	15.00
Memory composite	163	0.00	0.94	–2.89	1.87

M, mean; SD, standard deviation; Min, minimum; Max, maximum; BMI, body mass index; WSD, Western style diet; PSD, Prudent style diet; DST, diet screening tool; HbA1c, Glycated hemoglobin; cf-PWV, Carotid to femoral Pulse wave velocity; SUCCAB, Swinburne University Computerized Cognitive Assessment Battery; CM, Contextual memory; SWM, Spatial Working Memory; RVLT, Rey’s Verbal Learning Test.

Standardized beta coefficients from cognition regression analyses examining the effects of adherence to diet quality, WSD, PSD, glucose control (HbA1c) and carotid femoral pulse wave velocity (cf-PWV) are presented in Table 2. Each model was adjusted for the covariates described above. Lower cf-PWV significantly predicted better SWM performance after controlling for age, gender, education, energy, BMI, and the other independent variables (F Change (5,127) = 4.07, p = 0.045). The model predicted a total of 16.8%of the variance in SWM, of which cf-PWV accounted for an additional 2.4%of this variance above and that explained by the other predictors. There were no other significant relationships between cognitive performance and the other independent variables.

Table 2

Association of diet, glucose control and PWV with cognitive performance, standardized coefficients beta

	SUCCAB		RVLT
	SWM Per	CM Per	Total immediate recall	Maximum immediate recall	Delayed recall	Memory Composite
WSD	–0.033	–0.009	0.079	0.083	0.077	0.085
PSD	–0.031	0.087	–0.035	–0.041	–0.025	–0.036
DST	–0.007	0.044	–0.059	–0.039	–0.062	–0.057
HbA1c	–0.128	–0.122	–0.074	–0.026	–0.076	–0.128
Cf-PWV	–0.211^*	–0.043	–0.025	–0.039	–0.108	–0.062

^*p < 0.05 N = 163, Model adjusted for age, gender, education, energy intake, BMI. WSD, Western style diet; PSD, Prudent style diet; DST, diet screening tool; HbA1c, Glycated hemoglobin; cf-PWV, Carotid to femoral Pulse wave velocity; SUCCAB, Swinburne University Computerized Cognitive Ageing Battery; CM Per, Contextual memory performance; SWM Per, Spatial Working Memory performance; RVLT, Rey’s Verbal Learning Test.

In order to examine the interaction between the PSD and arterial stiffness, additional three stage hierarchical regressions were conducted. There was a significant interaction between PSD and cf-PWV for RVLT total immediate recall. While the control variables predicted 22%of the variance in RVLT total immediate recall (F Change (5,137) = 7.720, p < 0.001), the inclusion of the PSD and cf-PWV predicted an additional 0.1 %of the variance (F Change (2, 135) = 0.106, p = 0.899). Finally, the addition of the interaction term at stage three predicted an additional 3%of the variance (F Change (1,134) = 5.367, p = 0.022). There was also a significant interaction between PSD and cf-PWV for the composite score for RVLT. The control variables were found to predict 18.8%of the variance in RVLT composite score (F Change (5, 137) = 6.343, p < 0.001). The inclusion of the PSD and cf-PWV predicted an additional 0.4%of the variance (F Change (2, 135) = 0.309, p = 0.734). Finally, the addition of the interaction term at stage three predicted an additional 2.4%of the variance (F Change (1,134) = 4.034, p = 0.047). These two interaction effects are illustrated in Fig. 4.

Fig. 4

Interaction plot for selected cognitive tasks (significant). a) a. total recall across low, medium, and high levels of PSD and PWV. b) RVLT composite score across low, medium, and high levels of PSD and PWV. Low = one standard deviation below the mean (PSD: N = 31, PWV: N = 21); Medium = mean value; High = one standard deviation bove the mean (PSD: N = 30, PWV: N = 23).

Additional exploratory interactions were conducted for the other dietary patterns and diet quality with arterial stiffness and glucose control. However, there were no significant interactions between WSD and cf-PWV, WSD and HbA1c, Diet quality and PWV, and diet quality and HbA1c for any of the cognitive outcomes. The results did not differ when removing BMI as a covariate.

DISCUSSION

In this cross-sectional study of Australian older adults who may be at risk for future cognitive decline, we found that when studied as independent predictors, diet quality and adherence to either the WSD or PSD were not significantly related to cognitive performance. Likewise, there was no significant association between glucose control and cognitive performance. However, cf-PWV, a measure of arterial stiffness, was found to be a significant predictor of SWM performance, a measure that has been found to be sensitive to age associated cognitive decline [70]. We also found that cf-PWV significantly interacted with PSD to impact cognitive performance for total recall and the composite score of RVLT. To the best of the author’s knowledge, this is the first study to investigate the inter-relationship between the diet, arterial stiffness, glucose control, and cognitive performance.

The relationship observed between arterial stiffness and SWM is consistent with previous research. Kennedy et al. identified a significant association between cf-PWV and SWM performance scores in older adults. They found that cf-PWV (along with fitness) mediated the association between age and SWM performance [53]. Others have made similar observations regarding arterial stiffness and cognitive performance in older adults [41, 86] and in middle aged adults [87]. The participants in the current study were free from cardiovascular disease, indicating that even in individuals with ‘healthy’ cardiovascular function, elevated arterial stiffness may have implications for cognitive performance, particularly working memory.

Contrary to expectations we did not find a significant relationship between either of the dietary patterns or diet quality with cognitive performance. While there is evidence to support a link between diet and cognitive performance [16 , 88], data from other studies appears ambiguous or even contrary [89 –91]. Gardener et al. [26] also failed to link adherence to the PSD with cognitive performance, though the Mediterranean style diet and WSD were found to impact cognition. They suggested that despite adherence to a PSD reflecting that of the Mediterranean style diet, adherence to a PSD may not relate to cognition due to a reduced emphasis on fish consumption and subsequent intake of long chain omega-3 fatty acids. Further, the even though the current sample is of older adults, the mean age of 65years may not be old enough to detect a significant impact of diet on cognition. Another suggestion which may partially explain the results of the present study is that different dietary patterns may interact, and in turn, cancel out their effect on cognition. While the majority of past research has investigated adherence to a singular dietary pattern at a time, people tend to consume a variety of foods that may score on multiple dietary patterns and these different foods may interact to impact cognitive performance. For example, Shakersain et al. previously reported that adherence to the PSD attenuated the effects of the WSD on cognitive performance [92]. Another more recent study also found that the adherence to a WSD attenuates the protective role of the Mediterranean diet on cognitive decline [93]. Further, the current method of measuring diet may not be detailed enough to capture the current dietary patterns of the population under investigation. Participants may be adhering to another dietary pattern or variation of the WSD or PSD that was not captured by the FFQ used. In addition, the 20-item DST used to measure diet quality may not have sufficient detail to identify adequate nutrition risk in this population. All of these factors may have contributed to the present study failing to link diet as an independent predictor of cognitive performance.

This study is also the first to investigate how diet interacts with risk factors for cognitive decline to impact cognitive performance. The significant interaction for RVLT total recall suggests that for those with high adherence to the PSD, lower cf-PWV is conducive to better cognitive performance than is higher cf-PWV. This suggest that diet may not impact cognitive performance in isolation, rather its relationship with brain health may be due to complex interaction with other risk factors. Unexpectedly, individuals with low adherence to the PSD and high cf-PWV perform better than those with low adherence and low cf-PWV. This unusual relationship may be because low adherence to either diet pattern only provides information about what individuals are not consuming [26]. As a result, it is unclear what aspects of diet could be contributing to the relationship observed when looking at low adherence. It can also be observed in Fig. 4 that those with high adherence to the PSD and high PWV have the worst cognitive performance. This finding, while unexpected, suggests that once significant pathology has occurred (i.e., greater arterial stiffness), diet does not have a protective role for cognitive performance. The significant interaction between PSD and cf-PWV for the RVLT composite score indicates reduced variance in cognitive performance for individuals with low adherence to the PSD regardless of cf-PWV status, though individuals with lower cf-PWV appeared to demonstrate the worst performance. Conversely, there was markedly greater variance in RVLT composite score for individuals demonstrating high adherence to the PSD, with individuals concurrently demonstrating lower cf-PWV outperforming those with poorer cf-PWV (see Fig. 4). The combined interactions between the PSD and cf-PWV suggests that the PSD may not be an independent factor predicting cognitive performance but may operate in conjunction with measures of central arterial stiffness (e.g., cf-PWV). Future research should investigate more cardio protective dietary patterns such as the Mediterranean diet or the DASH diet in conjunction with cognitive and cardiovascular function, especially as the PSD was not found to have a beneficial effect for those with higher arterial stiffness.

Though there were only two significant interactions, the findings of this study provide important evidence that the risk factors for cognitive decline do not work in isolation. Another study to explore the interdependent relationships between various risk factors for cognitive decline and brain health was conducted by Mosconi et al. (2018) [94]. They found that diet and insulin sensitivity explained variability in cortical thickness, and this was then related to memory performance. The findings from this study and the current findings suggest that future research must consider these interactions between risk factors. This will help us better understand how these factors impact cognition and may enable intervention programs to be tailored to individuals needs and prioritizing those who will best benefit from lifestyle intervention.

The current study has several limitations. Firstly, the use of a cross sectional design does not allow for the assessment of cause and effect relationships. Therefore, all current findings need confirmation through both longitudinal studies and trials. Secon-dly, the sample size is relatively small in comparison to large cohort studies. This therefore limited the number of participants demonstrating WSD, PSD, diet quality scores, cf-PWV or HbA1c levels greater than one standard deviation above the mean for these factors. This prevented a slope analysis from being conducted and subsequent exploration of whether there were significant differences between levels of adherence to dietary patterns, cf-PWV and HbA1c levels. Thirdly, sole reliance on the FFQ limited the extent to which dietary adherence or quality could be assessed. Dietary analysis based on participant recall, a defining characteristic of an FFQ, is prone to error. This would be an especially pertinent limitation given the study involved participants who had self-reported memory complaints [26, 52]. Given these participants subjectively report issues with their memory, the accuracy at recalling the foods consumed over the last 12 months cannot be guaranteed. In order to address this limitation, future research should seek to utilize nutrient biomarkers such as those used by Bowman et al. to compliment data derived from FFQs [95]. Moreover, the FFQ used in the current study does not provide an indication as to the frequency, or amount, to which sugary sweetened beverages and olive oil is consumed. This is problematic as sugary beverages are consumed in high amounts in Australia [23] and have been found to increase the risk of stroke and dementia [96] and therefore potentially impact cognitive function, particularly in older adults. Likewise, olive oil has also been found to play an important role in healthy dietary patterns such as the Mediterranean diet and has been shown to play a protective role in regards to cognitive function [97, 98]. Further, the weighting of the food groups for the PSD (Supplementary Table 2) suggest that this dietary pattern may be over representing fruit and vegetable intake over other food groups. The current study only controlled for age, gender, education, and energy intake and BMI. Additional factors such as physical activity and participation in cognitive activities may also impact the relationship. Therefore, future studies should control for these measures as well. Finally, the current study considered results significant at the p < 0.05 level and did not correct for multiple comparisons, this needs to be taken into account when interpreting the findings as they may be due to chance.

Despite these limitations, the current study possessed a number of strengths. These include the use of covariates known to impact cognitive performance, diet, and cardiovascular and metabolic health. The use of age sensitive measures of cognition (SUCCAB and RVLT) are advantageous for detecting subtle associations between cognitive performance compared to generalized cognitive measures (e.g., MMSE) routinely utilized in aging research. The use of both SUCCAB and RVLT in the current study also allows for an increased number of cognitive domains to be assessed. Additionally, the use of a whole diet analysis is superior to investigating the individual food groups alone, as whole dietary analysis more accurately reflects real world food and nutrient consumption [92, 99]. Aside from dietary adherence, diet quality was also assessed to capture the overall nutritional risk of participants. Diet quality has been investigated as a predictor of cognitive function [31, 100] and may represent an important predictor of brain tissue integrity in older adults [101].

CONCLUSION

In this sample of older Australian adults at risk for future cognitive decline, diet alone was not an independent predictor of cognitive performance, but rather interacted with arterial stiffness (i.e., cf-PWV). Arterial stiffness was also found to significantly predict cognitive performance independently; however, no relationship was observed between glucose control and cognitive outcomes. The current study provides further evidence that diet and arterial stiffness may not be acting in isolation, but rather in a combined, perhaps even synergistic fashion. In particular, the findings from this study provide additional evidence that diet may be acting through cardiovascular health to impact cognition. Exploring how dietary factors interact with other important health factors (e.g., physical activity), may provide valuable information in regard to the progression of cognitive decline and how these factors could be modified to reduce the impact of unhealthy brain aging.

Footnotes

ACKNOWLEDGMENTS

The authors would like to thank Renee Rowsell, Rebecca King, Naomi Perry, Katheryn Cox, and Helen Macpherson for administrative support, oversight, and help setting up the RCT. The resources of Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, were used to conduct this study. The authors would also like to express our gratitude to the participants who volunteered their time for this study.

This study received funding from Arla Foods Ingredients Group P/S, Denmark. S.G. is funded by Australian Research Training Program Stipends. Arla Foods Ingredients Group P/S, Denmark had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Authors’ disclosures available online ().

The supplementary material is available in the electronic version of this article: .

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Diet May Moderate the Relationship Between Arterial Stiffness and Cognitive Performance in Older Adults

Abstract

Background:

Objective:

Methods:

Results:

Conclusion:

Keywords

INTRODUCTION

MATERIALS AND METHODS

Participants

Diet

Arterial stiffness assessment

Glucose control

Cognitive outcomes

Swinburne university computerized cognitive assessment battery (SUCCAB)

Rey’s verbal learning test (RVLT)

Data analyses

RESULTS

DISCUSSION

CONCLUSION

Footnotes

ACKNOWLEDGMENTS

References