Financial capacity is often one of the first instrumental activities of daily living to be affected in cognitively normal (CN) older adults who later progress to amnestic mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia.
Objective:
The objective of this study was to investigate the association between financial capacity and regional cerebral tau.
Methods:
Cross-sectional financial capacity was assessed using the Financial Capacity Instrument –Short Form (FCI-SF) in 410 CN, 199 MCI, and 61 AD dementia participants who underwent flortaucipir tau positron emission tomography from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Linear regression models with backward elimination were used with FCI-SF total score as the dependent variable and regional tau and tau-amyloid interaction as predictors of interest in separate analyses. Education, age, sex, Rey Auditory Verbal Learning Test Total Learning, and Trail Making Test B were used as covariates.
Results:
Significant associations were found between FCI-SF and tau regions (entorhinal: p < 0.001; inferior temporal: p < 0.001; dorsolateral prefrontal: p = 0.01; posterior cingulate: p = 0.03; precuneus: p < 0.001; and supramarginal gyrus: p = 0.005) across all participants. For the tau-amyloid interaction, significant associations were found in four regions (amyloid and dorsolateral prefrontal tau interaction: p = 0.005; amyloid and posterior cingulate tau interaction: p = 0.005; amyloid and precuneus tau interaction: p < 0.001; and amyloid and supramarginal tau interaction: p = 0.002).
Conclusion:
Greater regional tau burden was modestly associated with financial capacity impairment in early-stage AD. Extending this work with longitudinal analyses will further illustrate the utility of such assessments in detecting clinically meaningful decline, which may aid clinical trials of early-stage AD.
Alzheimer’s Association (2019) 2019 Alzheimer’s disease facts and figures. Alzheimers Dement15, 321–387.
2.
TabiraT, HottaM, MurataM, YoshiuraK, HanG, IshikawaT, KoyamaA, OgawaN, MarutaM, IkedaY, MoriT, YoshidaT, HashimotoM, IkedaM (2020) Age-related changes in instrumental and basic activities of daily living impairment in older adults with very mild Alzheimer’s disease. Dement Geriatr Cogn Dis Extra10, 27–37.
3.
JekelK, DamianM, WattmoC, HausnerL, BullockR, ConnellyPJ, DuboisB, EriksdotterM, EwersM, GraesselE, KrambergerMG, LawE, MecocciP, MolinuevoJL, NygardL, Olde-RikkertMG, OrgogozoJM, PasquierF, PeresK, SalmonE, SikkesSA, SobowT, SpiegelR, TsolakiM, WinbladB, FrolichL (2015) Mild cognitive impairment and deficits in instrumental activities of daily living: A systematic review. Alzheimers Res Ther7, 17.
4.
AhnIS, KimJH, KimS, ChungJW, KimH, KangHS, KimDK (2009) Impairment of instrumental activities of daily living in patients with mild cognitive impairment. Psychiatry Investig6, 180–184.
5.
DauphinotV, Delphin-CombeF, MouchouxC, DoreyA, BathsavanisA, MakaroffZ, RouchI, Krolak-SalmonP (2015) Risk factors of caregiver burden among patients with Alzheimer’s disease or related disorders: A cross-sectional study. J Alzheimers Dis44, 907–916.
6.
MarshallGA, AmariglioRE, SperlingRA, RentzDM (2012) Activities of daily living: Where do they fit in the diagnosis of Alzheimer’s disease?Neurodegener Dis Manag2, 483–491.
7.
RaccichiniA, CastellaniS, CiverchiaP, FioravantiP, ScarpinoO (2009) The caregiver’s burden of Alzheimer patients: Differences between live-in and non-live-in. Am J Alzheimers Dis Other Demen24, 377–383.
8.
MarsonDC, TriebelK, KnightA (2012) Financial capacity. In Civil capacities in clinical neuropsychology: Research findings and practical applications. Oxford University Press, New York, NY, US, pp. 39–68.
9.
GersteneckerA, EakinA, TriebelK, MartinR, Swenson-DravisD, PetersenRC, MarsonD (2016) Age and education corrected older adult normative data for a short form version of the Financial Capacity Instrument. Psychol Assess28, 737–749.
SherodMG, GriffithHR, CopelandJ, BelueK, KrzywanskiS, ZamriniEY, HarrellLE, ClarkDG, BrockingtonJC, PowersRE, MarsonDC (2009) Neurocognitive predictors of financial capacity across the dementia spectrum: Normal aging, mild cognitive impairment, and Alzheimer’s disease. J Int Neuropsychol Soc15, 258–267.
12.
RoyK, PepinLC, PhiliossaintM, LoriusN, BeckerJA, LocascioJJ, RentzDM, SperlingRA, JohnsonKA, MarshallGA (2014) Regional fluorodeoxyglucose metabolism and instrumental activities of daily living across the Alzheimer’s disease spectrum. J Alzheimers Dis42, 291–300.
13.
OgamaN, SakuraiT, NakaiT, NiidaS, SajiN, TobaK, UmegakiH, KuzuyaM (2017) Impact of frontal white matter hyperintensity on instrumental activities of daily living in elderly women with Alzheimer disease and amnestic mild cognitive impairment. PLoS One12, e0172484.
SalmonE, LespagnardS, MariqueP, PeetersF, HerholzK, PeraniD, HolthoffV, KalbeE, AnchisiD, AdamS, ColletteF, GarrauxG (2005) Cerebral metabolic correlates of four dementia scales in Alzheimer’s disease. J Neurol252, 283–290.
16.
HalawaOA, GatchelJR, AmariglioRE, RentzDM, SperlingRA, JohnsonKA, MarshallGA, Alzheimer’s Disease Neuroimaging Initiative (2019) Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer’s disease. Alzheimers Res Ther11, 14.
17.
MarshallGA, GatchelJR, DonovanNJ, MunizMC, SchultzAP, BeckerJA, ChhatwalJP, HanseeuwBJ, PappKV, AmariglioRE, RentzDM, SperlingRA, JohnsonKA (2019) Regional tau correlates of instrumental activities of daily living and apathy in mild cognitive impairment and Alzheimer’s disease dementia. J Alzheimers Dis67, 757–768.
18.
MarshallGA, FairbanksLA, TekinS, VintersHV, CummingsJL (2006) Neuropathologic correlates of activities of daily living in Alzheimer disease. Alzheimer Dis Assoc Disord20, 56–59.
19.
MarshallGA, LoriusN, LocascioJJ, HymanBT, RentzDM, JohnsonKA, SperlingRA (2014) Regional cortical thinning and cerebrospinal biomarkers predict worsening daily functioning across the Alzheimer’s disease spectrum. J Alzheimers Dis41, 719–728.
20.
TolbertS, LiuY, HellegersC, PetrellaJR, WeinerMW, WongTZ, Murali DoraiswamyP (2019) Financial management skills in aging, MCI and dementia: Cross sectional relationship to 18F-Florbetapir PET cortical beta-amyloid deposition. J Prev Alzheimers Dis6, 274–282.
21.
LeeJC, KimSJ, HongS, KimY (2019) Diagnosis of Alzheimer’s disease utilizing amyloid and tau as fluid biomarkers. Exp Mol Med51, 1–10.
22.
SuppiahS, DidierMA, VinjamuriS (2019) The who, when, why, and how of PET amyloid imaging in management of Alzheimer’s disease-review of literature and interesting images. Diagnostics (Basel)9, 65.
23.
IqbalK, LiuF, GongCX, Grundke-IqbalI (2010) Tau in Alzheimer disease and related tauopathies. Curr Alzheimer Res7, 656–664.
24.
FranzmeierN, NeitzelJ, RubinskiA, SmithR, StrandbergO, OssenkoppeleR, HanssonO, EwersM, Alzheimer’s Disease Neuroimaging I (2020) Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease. Nat Commun11, 347.
25.
JohnsonKA, SchultzA, BetenskyRA, BeckerJA, SepulcreJ, RentzD, MorminoE, ChhatwalJ, AmariglioR, PappK, MarshallG, AlbersM, MauroS, PepinL, AlverioJ, JudgeK, PhiliossaintM, ShoupT, YokellD, DickersonB, Gomez-IslaT, HymanB, VasdevN, SperlingR (2016) Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann Neurol79, 110–119.
26.
LiY, YaoZ, YuY, ZouY, FuY, HuB, Alzheimer’s Disease Neuroimaging Initiative (2019) Brain network alterations in individuals with and without mild cognitive impairment: Parallel independent component analysis of AV1451 and AV45 positron emission tomography. BMC Psychiatry19, 165.
27.
XieL, DasSR, WisseLEM, IttyerahR, YushkevichPA, WolkDA, Alzheimer’s Disease Neuroimaging Initiative (2018) Early tau burden correlates with higher rate of atrophy in transentorhinal cortex. J Alzheimers Dis62, 85–92.
28.
SperlingRA, MorminoEC, SchultzAP, BetenskyRA, PappKV, AmariglioRE, HanseeuwBJ, BuckleyR, ChhatwalJ, HeddenT, MarshallGA, QuirozYT, DonovanNJ, JacksonJ, GatchelJR, RabinJS, JacobsH, YangHS, ProperziM, KirnDR, RentzDM, JohnsonKA (2019) The impact of amyloid-beta and tau on prospective cognitive decline in older individuals. Ann Neurol85, 181–193.
29.
WeinerMW, VeitchDP, AisenPS, BeckettLA, CairnsNJ, GreenRC, HarveyD, JackCR, JagustW, LiuE, MorrisJC, PetersenRC, SaykinAJ, SchmidtME, ShawL, SiuciakJA, SoaresH, TogaAW, TrojanowskiJQ, Alzheimer’s Disease Neuroimaging Initiative (2012) The Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception. Alzheimers Dement8, S1–68.
30.
ReyA (1964) L’examen clinique en psychologie [The clinical examination in psychology]. Presses Universitaries De France.
31.
ReitanR (1958) Validity of the trail making test as an indicator of organic brain damage. Percept Mot Skills8, 271–276.
32.
LandauSM, BreaultC, JoshiAD, PontecorvoM, MathisCA, JagustWJ, MintunMA, Alzheimer’s Disease Neuroimaging Initiative (2013) Amyloid-beta imaging with Pittsburgh compound B and florbetapir: Comparing radiotracers and quantification methods. J Nucl Med54, 70–77.
33.
TosunD, LandauS, AisenPS, PetersenRC, MintunM, JagustW, WeinerMW, Alzheimer’s Disease Neuroimaging Initiative (2017) Association between tau deposition and antecedent amyloid-beta accumulation rates in normal and early symptomatic individuals. Brain140, 1499–1512.
34.
LandauSM, HarveyD, MadisonCM, KoeppeRA, ReimanEM, FosterNL, WeinerMW, JagustWJ, Alzheimer’s Disease Neuroimaging Initiative (2011) Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI. Neurobiol Aging32, 1207–1218.
35.
VidoniED, HoneaRA, BurnsJM (2010) Neural correlates of impaired functional independence in early Alzheimer’s disease. J Alzheimers Dis19, 517–527.
36.
Schmitter-EdgecombeM, WooE, GreeleyDR (2009) Characterizing multiple memory deficits and their relation to everyday functioning in individuals with mild cognitive impairment. Neuropsychology23, 168–177.
37.
MarshallGA, RentzDM, FreyMT, LocascioJJ, JohnsonKA, SperlingRA, Alzheimer’s Disease Neuroimaging Initiative (2011) Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer’s disease. Alzheimers Dement7, 300–308.
38.
LilamandM, CesariM, CantetC, PayouxP, AndrieuS, VellasB, the MAPT/DSA study group (2018) Relationship between brain amyloid deposition and instrumental activities of daily living in older adults: A longitudinal study from the Multidomain Alzheimer Prevention Trial. J Am Geriatr Soc66, 1940–1947.
39.
TangMX, SternY, MarderK, BellK, GurlandB, LantiguaR, AndrewsH, FengL, TyckoB, MayeuxR (1998) The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics. JAMA279, 751–755.
