Abstract
The present study examined the relationships among statin use, APOE genotype, and insulin resistance as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) in healthy older adults. APOE ε4- (i.e., not having an ε4 allele) statin users had higher HOMA-IR values compared with ε4+/statin users (p = 0.0169), and with non-users who were ε4- (p = 0.0003) or ε4+ (p = 0.0006). These results suggest that statin use may modulate insulin levels for individuals without an APOE ε4 allele.
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