Genetic Deficiency of Plasma Lipoprotein-Associated Phospholipase A 2 (PLA2G7 V297F Null Mutation) and Risk of Alzheimer's Disease in Japan

Abstract

High plasma lipoprotein phospholipase A₂ activity (Lp-PLA₂) is reported to be a risk factor for dementia. A loss of function polymorphism in the Lp-PLA₂ gene – PLA2G7 V279F – is found almost exclusively in Asians. In 1,952 subjects with late-onset AD and 2,079 non-demented controls recruited from Japan, the PLA2G7 null allele was not associated with risk or age at onset of AD: logistic regression OR 0.98 (95% CI 0.86–1.12, p = 0.81) per additional null allele, adjusted for age/age at onset, gender, and APOE ε4. Genetic deficiency of Lp-PLA₂ activity is not associated with a reduced risk of AD in the Japanese population.