Suppression of longitudinal increase in CSF F 2 -isoprostanes in Alzheimer's disease

Abstract

We report the first longitudinal analysis of cerebrospinal fluid (CSF) F₂-isoprostanes (IsoPs), quantitative in vivo biomarkers of lipid peroxidation, in patients with mild Alzheimer's disease (AD). CSF F₂-IsoPs (i) were significantly increased in patients followed over one year, (ii) correlated with some clinical indices of dementia following correction for variation in ventricular enlargement, and (iii) were significantly lower in patients who used both α-tocopherol and vitamin C.