Abstract

Get full access to this article
View all access options for this article.
References
1.
Kumar
DKV
,
Choi
HS
,
Washicosky
KJ
,
Eimer
WA
,
Tucker
S
,
Ghofrani
J
,
Lefkowitz
A
,
McColl
G
,
Goldstein
LE
,
Tanzi
RE
,
Moir
RD
(2016 ) Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease . Sci Transl Med 8 , 340ra72 .
2.
Bishop
GM
,
Robinson
SR
(2002 ) The amyloid hypothesis: Let sleeping dogmas lie? Neurobiol Aging 23 , 1101 –1105 .
3.
Wozniak
M
,
Mee
AP
,
Itzhaki
RF
(2009 ) Herpes simplex virus type 1 DNA is located within Alzheimer’s disease amyloid plaques . J Pathol 217 , 131 –138 .
4.
Itzhaki
RF
(2018 ) Corroboration of a major role for herpes simplex virus type 1 in Alzheimer’s disease . Front Aging Neurosci 10 , 324 .
5.
Tzeng
NS
,
Chung
CH
,
Lin
FH
,
Chiang
CP
,
Yeh C
Bin
,
Huang
SY
,
Lu
RB
,
Chang
HA
,
Kao
YC
,
Yeh
HW
,
Chiang
WS
,
Chou
YC
,
Tsao
CH
,
Wu
YF
,
Chien
WC
(2018 ) Anti-herpetic medications and reduced risk of dementia in patients with herpes simplex virus infections—a nationwide, population-based cohort study in Taiwan . Neurotherapeutics 15 , 417 –429 .
6.
Itzhaki
RF
,
Lathe
R
(2018 ) Herpes viruses and senile dementia: first population evidence for a causal link . J Alzheimers Dis 64 , 363 –366 .
7.
Readhead
B
,
Haure-Mirande
JV
,
Funk
CC
,
Richards
MA
,
Shannon
P
,
Haroutunian
V
,
Sano
M
,
Liang
WS
,
Beckmann
ND
,
Price
ND
,
Reiman
EM
,
Schadt
EE
,
Ehrlich
ME
,
Gandy
S
,
Dudley
JT
(2018 ) Multiscale analysis of independent Alzheimer’s cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus . Neuron 99 , 64 –82 .
8.
Lin
WR
,
Wozniak
MA
,
Cooper
RJ
,
Wilcock
GK
,
Itzhaki
RF
(2002 ) Herpesviruses in brain and Alzheimer’s disease . J Pathol 197 , 395 –402 .
9.
Venegas
C
,
Kumar
S
,
Franklin
BS
,
Dierkes
T
,
Brinkschulte
R
,
Tejera
D
,
Vieira-Saecker
A
,
Schwartz
S
,
Santarelli
F
,
Kummer
MP
,
Griep
A
,
Gelpi
E
,
Beilharz
M
,
Riedel
D
,
Golenbock
DT
,
Geyer
M
,
Walter
J
,
Latz
E
,
Heneka
MT
(2017 ) Microglia-derived ASC specks crossseed amyloid-β in Alzheimer’s disease . Nature 552 , 355 .
10.
Tejera
D
,
Mercan
D
,
Sanchez-Caro
JM
,
Hanan
M
,
Greenberg
D
,
Soreq
H
,
Latz
E
,
Golenbock
D
,
Heneka
MT
(2019 ) Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome . EMBO J 38 , e101064 .
11.
Keshavan
M
(2019 ) On Alzheimer’s, scientists head back to the drawing board — and once-shunned ideas get an audience. STAT News , https://www.statnews.com/2019/07/22/on-alzheimers-scientists-head-back-to-the-drawing-board-and-once-shunned-ideas-get-an-audience/, Posted 22 July 2019, Accessed 21 August 2019.
12.
Devanand
DP
. Anti-viral Therapy in Alzheimer’s Disease. https://clinicaltrials.gov/ct2/show/NCT03282916, Last updated 11 April 2019, Accessed 21 August 2019.
13.
Poole
S
,
Singhrao
SK
,
Chukkapalli
S
,
Rivera
M
,
Velsko
I
,
Kesavalu
L
,
Crean
SJ
(2015 ) Active invasion of porphyromonas gingivalis and infection-induced complement activation in apoe-/- mice brains . J Alzheimers Dis 43 , 67 –80 .
14.
Dominy
SS
,
Lynch
C
,
Ermini
F
,
Benedyk
M
,
Marczyk
A
,
Konradi
A
,
Nguyen
M
,
Haditsch
U
,
Raha
D
,
Griffin
C
,
Holsinger
LJ
,
Arastu-Kapur
S
,
Kaba
S
,
Lee
A
,
Ryder
MI
,
Potempa
B
,
Mydel
P
,
Hellvard
A
,
Adamowicz
K
,
Hasturk
H
,
Walker
GD
,
Reynolds
EC
,
Faull
RLM
,
Curtis
MA
,
Dragunow
M
,
Potempa
J
(2019 ) Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors . Sci Adv 5 , eaau3333 .
15.
National Institute on Aging (1 April 2019) Notice of Special Interest: High-Priority Research Topic for PAR-19-070. Retrieved from https://grants.nih.gov/grants/guide/notice-files/NOT-AG-19-012.html.
