Abstract
Previous studies suggest that gut microbiota is associated with neuropsychiatric
disorders, such as Parkinson’s disease, amyotrophic lateral sclerosis, and depression.
However, whether the composition and diversity of gut microbiota is altered in patients
with Alzheimer’s disease (AD) remains largely unknown. In the present study, we collected
fecal samples from 43 AD patients and 43 age- and gender-matched cognitively normal
controls. 16S ribosomal RNA sequencing technique was used to analyze the microbiota
composition in feces. The composition of gut microbiota was different between the two
groups. Several bacteria taxa in AD patients were different from those in controls at
taxonomic levels, such as
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