Apparent Cognitive Decline as Revealed by an Executive Function Test within a Cohort of Elderly Individuals Self-Reporting Normal Cognitive Performance
Restricted accessResearch articleFirst published online January 9, 2018
Apparent Cognitive Decline as Revealed by an Executive Function Test within a Cohort of Elderly Individuals Self-Reporting Normal Cognitive Performance
Alzheimer’s disease (AD) can be preceded by subtle memory decline that can last a decade or more before progressing to what would be diagnosed as the mild cognitive impairment stage. During this early stage of decline, individuals and even their caregivers can fail to perceive any serious difficulty or need to consult a physician. Herein, we present evidence in support of these concerns, and demonstrate how this can interfere not only with clinical trials of AD but also those involving cognitive performance of elderly individuals without intentional reference to AD.
CaselliRJ, BeachTG, KnopmanDS, Graff-RadfordNR (2017) Alzheimer disease: Scientific breakthroughs and translational challenges. Mayo Clin Proc92, 978–994.
2.
KoskasP, Pons-PeyneauC, Houenou-QuenumN, RomdhaniM, GasmiM, GalleronS, DrunatO (2017) Factors influencing time between onset of signs/symptoms and referral for dementia in elderly outpatients. Rev Neurol (Paris), doi: 10.1016/j.neurol.2017.05.012
3.
McGoughE, Kirk-SanchezN, Liu-AmbroseT (2017) Integrating health promotion into physical therapy practice to improve brain health and prevent Alzheimer disease. J Neurol Phys Ther41, S55–S62.
4.
ShliskyJ, BloomDE, BeaudreaultAR, TuckerKL, KellerHH, Freund-LeviY, FieldingRA, ChengFW, JensenGL, WuD, MeydaniSN (2017) Nutritional considerations for healthy aging and reduction in age-related chronic disease. Adv Nutr8, 17–26.
5.
KnightA, BryanJ, MurphyK (2016) Is the Mediterranean diet a feasible approach to preserving cognitive function and reducing risk of dementia for older adults in Western countries? New insights and future directions. Ageing Res Rev25, 85–101.
6.
GallagherD, KissA, LanctotK, HerrmannN (2016) Depressive symptoms and cognitive decline: A longitudinal analysis of potentially modifiable risk factors in community dwelling older adults. J Affect Disord190, 235–240.
7.
LeeSH, KimYB (2016) Which type of social activities may reduce cognitive decline in the elderly?: A longitudinal population-based study. BMC Geriatr16, 165.
8.
SheaTB, RogersE, RemingtonR (2012) Nutrition and dementia: Are we asking the right questions?J Alzheimers Dis30, 27–33.
9.
SheaTB, RemingtonR (2012) Positive argument for debate in J Neural Transmission: Alzheimer’s disease: Are we intervening too late? Yes, by decades. J Neural Trans119, 1529–1532.
10.
HertzogC, KramerAF, WilsonRS, LindenbergerU (2008) Enrichment effects on adult cognitive development: Can the functional capacity of older adults be preserved and enhanced?Psychol Sci Public Interest9, 1–65.
11.
BarekatainM, AlaviradM, TavakoliM, EmsakiG, MaracyMR (2016) Cognitive rehabilitation in patients with nonamnestic mild cognitive impairment. J Res Med Sci21, 101.
12.
ChanA, LeporeA, KotoyaE, ZemianekJ, RemingtonR, SheaTB (2010) Efficacy of a vitamin/nutriceutical formulation on cognitive speed and recall in adults with no known or suspected dementia. J Nutri Health Aging14, 224–230.
13.
RemingtonR, BechtelC, LarsenD, LortieJJ, SamarA, DoshanjhL, FishmanP, LuoY, SmyersK, HoffmannH, BarysauskasC, BartonB, SheaTB (2015) A nutritional formulation for cognitive performance and mood in Alzheimer’s disease: A phase II multi-site randomized trial with an open-label extension. J Alzheimers Dis45, 395–405.
14.
RemingtonR, LortieJ, HoffmanH, PageR, MorrellC, SheaTB (2015) A nutritional formulation for cognitive performance in mild cognitive impairment: A placebo-controlled trial with an open-label extension. J Alzheimers Dis48, 591–595.
15.
BradfordA, KunikME, SchultzP, WilliamsSP, SinghH (2009) Missed and delayed diagnosis of dementia in primary care: Prevalence and contributing factors. Alzheimer Dis Assoc Disord23, 306–314.
16.
KotagalV, LangaKM, PlassmanBL, FisherGG, GiordaniBJ, WallaceRB, BurkeJR, SteffensDC, KabetoM, AlbinRL, FosterNL (2015) Factors associated with cognitive evaluations in the United States. Neurology84, 64–71.
17.
BarrettAM, OrangeW, KellerM, DamgaardP, SwerdlowRH (2006) Short-term effect of dementia disclosure: How patients and families describe the diagnosis. J Am Geriatr Soc54, 1968–1970.
18.
JessenF (2014) Subjective and objective cognitive decline at the pre-dementia stage of Alzheimer’s disease. Eur Arch Psychiatry Clin Neurosci264, S3–S7.
19.
VanniniP, AmariglioR, HanseeuwB, JohnsonKA, McLarenDG, ChhatwalJ, Pascual-LeoneA, RentzD, SperlingRA (2017) Memory self-awareness in the preclinical and prodromal stages of Alzheimer’s disease. Neuropsychologia99, 343–349.
20.
BegumA, MorganC, ChiuCC, TyleeA, StewartR (2012) Subjective memory impairment in older adults: Aetiology, salience and help seeking. Int J Geriatr Psychiatry27, 612–620.
