Abstract
The association of smoking with preclinical cognitive decline remains unclear and may be modified by the APOE ɛ4 genotype. In 5,705 participants (mean age: 63.9±9.1 years; 57.4% women) from the population-based Rotterdam Study, we investigated the relationship between smoking and cognitive decline over a 5.5-year period and examined potential effect modification by APOE ɛ4 genotype. We found that current smoking was related to decline in global cognition [difference compared to never smoking: –0.06 (95% C.I.–0.10;–0.01)], as well as decline on specific cognitive tests including the Letter Digit Substitution Task, the 15-Word Learning Test, and the Purdue Pegboard. We found no evidence for effect modification by APOE ɛ4 genotype on this relation.
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