This study assessed the effect of stimulating the somatosensory system of Alzheimer’s disease (AD) patients at three stages of their illness with 40 Hz sound. In this AB cross-over study design, 18 participants (6 mild, 6 moderate, 6 severe) each participated in 13 sessions: one intake and 12 treatment. Treatment A consisted of 40 Hz sound stimulation and Treatment B consisted of visual stimulation using DVDs, each provided twice a week over 6 weeks for a total of 6 times per treatment. Outcome measures included: St. Louis University Mental Status Test (SLUMS), Observed Emotion Rating Scale, and behavioral observation by the researcher. Data were submitted to regression analysis for the series of 6 SLUMS scores in treatment A and 6 scores in B with comparison by group. The slopes for the full sample and subgroups in the 40 Hz treatment were all significant beyond alpha = 0.05, while those for the DVD were not. A thematic analysis of qualitative observations supported the statistical findings. 40 Hz treatment appeared to have the strongest impact on persons with mild and moderate AD. Results are promising in terms of a potential new treatment for persons with AD, and further research is needed.
OlazaranJ, ReisbergB, ClareL, CruzI, Peña-CasanovaJ, Del SerT, WoodsB, BeckC, AuerS, LaiC, SpectorA, FazioS, BondJ, KivipeltoM, BrodatyH, RojoJM, CollinsH, TeriL, MittelmanM, OrrellM, FeldmanHH, MuñizR (2010) Nonpharmacological therapies in Alzheimer’s disease: A review of efficacy. Dement Geriatr Cogn Disord30, 161–178.
7.
TurpieI (2014) Global aging: Challenges and opportunities from a health care perspective. Presented at: Landscapes of Aging CAG conference, October 2014, Niagara Falls, ON.
8.
RibaryU, IoannidestAA, SinghtKD, HassontR, BoltontJPR, LadoF, MogilnerA, LlinasR (1991) Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans. Proc Natl Acad Sci U S A88, 11037–11041.
9.
LlinasR, RibaryU (1993) Coherent 40-HZ oscillation characterizes dream state in humans. Proc Natl Acad Sci U S A90, 2078–2081.
RossB, JamaliS, MiyazakiT, FujiokaT (2013) Synchronization of beta and gamma oscillations in the somatosensory evoked neuromagnetic steady-state response. Exp Neurol245, 40–51.
12.
BartelL (2013) Vibroacoustic therapy. In International Dictionary of Music Therapy, Kirkland, K, ed. Routledge, New York, pp. 138.
13.
BartelL (2013) Physioacoustic method. In International Dictionary of Music Therapy, Kirkland, K, ed. Routledge, New York, pp. 99.
14.
BartelL (2013) Low frequency sound therapy. In International Dictionary of Music Therapy, Kirkland, K, ed. Routledge, New York, pp. 70–71.
15.
WigramT (1997) The effect of vibroacoustic therapy compared with music and movement based physiotherapy on multiply handicapped patients with high muscle tone and spasticity. In Music Vibration and Health, WigramT, DileoC, eds. Jeffery Books, Cherry Hill, NJ, pp. 69–85.
16.
KarkkainenM, MitsuiJ (2006) The effects of sound based vibration treatment on the human mind and body: The physioacoustic method. J Int Soc Life Inform Sci24, 155–159.
17.
ZhengA, SakariR, ChengSM, HietikkoA, MoilanenP, TimonenJ, FagerlundKM, KärkkäinenM, AlènM, ChengS (2009) Effects of a low-frequency sound wave therapy programme on functional capacity, blood circulation and bone metabolism in frail old men and women. Clin Rehabil23, 897–908.
18.
McKhannGM, KnopmanDS, ChertkowH, HymanBT, JackCRJr, KawasCH, KlunkWE, KoroshetzWJ, ManlyJJ, MayeuxR, MohsRC, MorrisJC, RossorMN, ScheltensP, CarrilloMC, ThiesB, WeintraubS, PhelpsCH (2011) The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging and the Alzheimer’s Association workgroup. Alzheimers Dement7, 263–269.
19.
American Psychiatric Association
(2000) Diagnostic and statistical manual of mental disorders: DSM-IV-TR. Washington, DC.
The Best Caribbean Beaches. Dir. Greg Voevodsky. Powerfloe Network. 2003, DVD.
22.
TariqSH, TumosaN, ChibnallJT, PerryHMIII, MorleyJE (2006) The Saint Louis University Mental Status (SLUMS) Examination for detecting mild cognitive impairment and dementia is more sensitive than the Mini-Mental Status Examination (MMSE) – A pilot study. Am J Geriatr Psychiatry14, 900–910.
23.
LawtonMP, Van HaitsmaK, KlapperJA (1999) Observed Emotion Rating Scale. Madlyn and Leonard Abramson Centre for Jewish Life, http://www.abramsoncenter.org/PRI Accessed May 22 2015.
24.
HuangC, WahlundLO, DierksT, JulinP, WinbladB, JelicB (2000) Discrimination of Alzheimer’s disease and mild cognitive impairment by equivalent EEG sources: A cross-sectional and longitudinal study. Clin Neurophysiol111, 161–167.
25.
Van DeursenJ (2009) Functional and structural brain markers of Alzheimer’s disease: Clinical studies using EEG and VBM. NeuroPsych Publishers, Maastricht, The Netherlands.
26.
JeongJ (2004) EEG dynamics in patients with Alzheimer’s disease. Clin Neurophysiol115, 1490–1505.
27.
van DeursenJA, VuurmanEFPM, VerheyFRJ, van Kranen-MastenbroekVHJM, RiedelWJ (2008) Increased EEG gamma band activity in Alzheimer’s disease and mild cognitive impairment. J Neural Transm115, 1301–1311.
28.
RibaryU (2005) Dynamics of thalamo-cortical network oscillations and human perception. In, Laureys S, ed. Progress in Brain Research150, 127–142.
29.
RibaryU, LlinasR, KlugerA, CappellJ, SukJ, FerrisSH (1990) Dynamics of magnetic auditory evoked steady-state responses in Alzheimer patients. Electroencephalogr Clin Neurophysiol Suppl75, S126.
30.
PaulRH, ClarkRC, LawrenceJ, GoldbergE, WilliamsLM, CooperN, CohenRA, BrickmanAM, GordonE (2005) Age-dependent change in executive function and gamma 40 Hz phase synchrony. J Integr Neurosci4, 63–76.
31.
Griskova-BulanovaI, DapsysK, MaciulisV (2013) Does brain ability to synchronize with 40 Hz auditory stimulation change with age?Acta Neurobiol Exp73, 564–570.
32.
OsipovaD, PekkonenE, AhveninenJ (2006) Enhanced magnetic auditory steady-state response in early Alzheimer’s disease. Clin Neurophysiol117, 1990–1995.
33.
GoutagnyR, KranticS (2013) Hippocampal oscillatory activity in Alzheimer’s disease: Toward the identification of early biomarkers?Aging Dis4, 134–140.
34.
LozanoAM, LipsmanN (2013) Probing and regulating dysfunctional circuits using deep brain stimulation. Neuron77, 406–424.
35.
CotelliM, CalabriaM, ManentiR, RosiniS, ZanettiO, CappaSF, MiniussiC (2011) Improved language performance in Alzheimer disease following brain stimulation. J Neurol Neurosurg Psychiatry82, 794–797.
36.
JamaliS, RossB (2013) Somatotopic finger mapping using MEG: Toward an optimal stimulation paradigm. Clin Neurophysiol124, 1659.
37.
FriesP (2005) A mechanism for cognitive dynamics: Neuronal communication through neuronal coherence. Trends Cogn Sci9, 474–480.
KoikeY, IwamotoS, KimataY, NohnoT, HiragamiF, KawamuraK, NumataK, MuraiH, OkisimaK, IwataM, KanoY (2004) Low-frequency vibratory sound induces neurite outgrowth in PC12m3 cells in which nerve growth factor-induced neurite outgrowth is impaired. Tiss Cult Res Commun23, 81–90.
40.
PatelA (2003) A new approach to the cognitive neuroscience of melody. In The Cognitive Neuroscience of Music, PeretzI, ZatorreR eds. Oxford University Press, Oxford, pp. 325–345.
