Lifetime History of Depression Predicts Increased Amyloid-β Accumulation in Patients with Mild Cognitive Impairment

[Journal of Alzheimer’s Disease 45(3), 2015, 907-919.DOI 10.3233/JAD-142931]

The ADNI reported AV-45 mean values on figure 2 (page 912) and table 2 (page 914) were raw AV-45 values, and should be changed to AV-45 SUVR values.

Therefore, the regional AV-45 SUVR values on Figure 2 and table 2 have changed in the corrected Figure 2 and Table 2 below.

Table II

Comparison of region-of-interest based AV-45 SUVR between aMCI patients with a lifetime history of major depression and aMCI patients without a lifetime history of major depression

Regions of interest	aMCI-LMD (n = 39)		aMCI+LMD (n = 39)		F-value	p-value
	SUVR	(SD)	SUVR	(SD)
	mean		mean
Frontal ∗	1.32	0.21	1.39	0.27	4.29	0.04 ∗
Cingulate	1.43	0.21	1.50	0.29	3.94	0.05
Parietal	1.33	0.21	1.39	0.25	3.41	0.07
Temporal	1.24	0.19	1.29	0.23	2.88	0.10

Abbreviations: aMCI = amnestic mild cognitive impairment; aMCI+LMD = aMCI with a lifetime history of major depression; aMCI-LMD = aMCI without any lifetime history of major depression; ANCOVA = analysis of covariance; AV-45 SUVR =¹⁸F-Florbetapir standardized uptake value ratio with a reference to cerebellar grey matter.