Adults at Increased Alzheimer’s Disease Risk Display Cognitive-Motor Integration Impairment Associated with Changes in Resting-State Functional Connectivity: A Preliminary Study
Restricted accessResearch articleFirst published online August 3, 2016
Adults at Increased Alzheimer’s Disease Risk Display Cognitive-Motor Integration Impairment Associated with Changes in Resting-State Functional Connectivity: A Preliminary Study
Background: Many neuroimaging parameters have demonstrated utility as
biomarkers in preclinical AD, including resting-state functional connectivity in the
default mode network. However, neuroimaging is not a practical, cost effective screening
instrument.
Objective: Here we investigate the relationship between performance on a
cognitive-motor integration assessment and alterations in resting-state functional
connectivity in an at-risk population.
Methods: Three groups of ten adults (young: mean age = 26.6 ± 2.7, low AD
risk: mean age = 58.7 ± 5.6, and high AD risk: mean age = 58.5 ± 6.9) performed a simple
cognitive-motor integration task using a dual-touchscreen laptop and also underwent
functional magnetic resonance imaging at rest.
Results: We found poorer cognitive-motor integration performance in high AD
risk participants, as well as an association with lower resting-state functional
connectivity in this group.
Conclusion: These findings provide novel insight into underlying AD-related
brain alterations associated with a behavioral assessment that can be easily administered
clinically.
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