Common Variants in PLD3 and Correlation to Amyloid-Related Phenotypes in Alzheimer’s Disease

Abstract

Abstract

The phospholipase D3 (PLD3) gene has shown association with Alzheimer’s disease (AD). However, the role of PLD3 common variants in amyloid-β (Aβ) pathology remains unclear. We examined the association of thirteen common single nucleotide polymorphisms (SNPs) with cerebrospinal fluid (CSF) Aβ _1 - 42 levels and florbetapir retention on florbetapir ¹⁸F amyloid positron emission tomography (AV45-PET) in a large population. We found that one SNP (rs11667768) was significantly associated with CSF Aβ _1 - 42 levels in the normal cognition group. We did not observe an association of any SNP with florbetapir retention. Our study predicted the potential role of PLD3 variants in Aβ pathology.