The purpose of this study was to examine varying degrees of knee flexion on isokinetic eversion (E) to inversion (I) strength ratios. Twenty healthy subjects volunteered for this study. Concentric (CON) peak torque (PT) of both ankles (dominant, non-dominant) at three different angles of knee flexion (15°, 30°, 45°) and two different velocities (30°/s, 120°/s) was assessed with ankle plantar flexion maintained at 10°. The E
_{CON}
:I
_{CON}
ratios at 30°/s ranged from 0.87 to 1.04 across all three angles, while those at 120°/s ranged from 0.86 to 1.00 indicating no differences in ratios between knee-flexion angles or ankles. However, there was a trend in lower ratios evident in the dominant compared to non-dominant ankles. These results suggest that subjects may be positioned with knee flexion angles ranging from 15° to 45° without influencing the outcome of the ankle eversion and inversion strength measurements.