This article pinpoints the essential factors influencing hospital information system (HIS) acceptance. The principal HIS users are physicians, who play a preeminent role in healthcare services. Gleaned from hospital physicians in Pakistan, questionnaire data help evaluate HIS acceptance. The critical factors affecting it are assessed through structural equation modeling (SEM), using a partial least squares (PLS) software. The results show that human compatibility, organizational support and HIS quality positively affect both HIS perceived usefulness and HIS perceived ease of use. Subsequently, these two intermediate factors positively affect hospital information system acceptance. Despite its limitations, the study not only contributes theoretically, but also yields both future-research directions and practical policymaking guidelines, so that healthcare providers deliver what HIS users need.
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