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Abstract

BACKGROUND:

There is the paucity of HTLV-1/-2 studies on Nigerian pregnant women despite the medical and public health significance of maternal-to-child transmission of HTLV-1/-2.

OBJECTIVE:

This study aims to determine the seroprevalence and risk factors of HTLV-1/-2 infections among pregnant women attending the University of Abuja Teaching Hospital (UATH), Abuja, Nigeria.

MATERIALS AND METHODS:

Blood samples were collected from consented pregnant women and analysed for ant-HTLV-1/-2 total antibodies using a commercial Enzyme-Linked Immunosorbent Assay (ELISA) kit. Pretested structured questionnaires were used to collate participants’ socio-demographic variables and risk factors of HTLV infection.

RESULTS:

Out of the 156 pregnant women tested for HTLV-1/-2 antibodies, 16 (10.3%) were seropositive. There was no significant association between the socio-demographic variables collated and seroprevalence of HTLV-1/-2 infection among pregnant women ( $p>$ 0.05). Pregnant women with HIV infection had a lower prevalence of HLTV-1/-2 infection than those without HIV infections (7.5% versus 11.7%). Pregnant women with multiple sexual partners had a higher risk of HTLV-1/-2 infection than those who had single (OR $=$ 2.08, 95% CI: 0.53–8.18). Women with a history of needles injury had a higher risk of HTLV-1/-2 infection than those who do not (OR $=$ 1.24, 95% CI: 0.38–4.08). The history of blood transfusion was significantly associated with HTLV-1/-2 infection ( $p=$ 0.027). However, no significant association existed between other risk factors of HTLV-1/-2 infection among pregnant women ( $p>$ 0.05).

CONCLUSION:

Considering the 3% pooled national prevalence of HTLV-1/-2 infection in Nigeria, the seroprevalence reported in this study is relatively high. Thus, there is a need for more large cohort studies and routine screening of population at increased risk of infection.

Keywords

Retroviruses vertical transmission serological survey HTLV maternal infection Nigeria

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Sero-epidemiology of human T-cell lymphotropic viruses-1 and -2 infection among pregnant women attending Abuja Teaching Hospital,Nigeria

Abstract

BACKGROUND:

OBJECTIVE:

MATERIALS AND METHODS:

RESULTS:

CONCLUSION:

Keywords

Get full access to this article

References