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Abstract

BACKGROUND AND OBJECTIVES:

The aim of this study was to investigate the T helper (Th) to T cytotoxic (Tc) ratio in children suffering from type A hemophilia disease and to evaluate the correlation of this ratio with disease severity.

MATERIAL AND METHOD:

Two mls of EDTA anti coagulated whole blood was collected. Immunophenotyping of lymphocytes count was carried out by FACS analysis using a double CD4 and CD8 kit. The mean $\pm$ SD of absolute numbers of CD4 and CD8 lymphocytes/ml was calculated and the ratio of CD4/CD8 was evaluated by statistical method.

RESULTS:

Among 80 type A hemophilia patients, 66 (82.5%) were male. The mean age was 15 $\pm$ 3.51 years. 12 (15%) of them were suffering from mild disease and 68 (85%) had sever disease. The CD4 /CD8 ratio was obtained between 0.45 and 1.44 with mean1.79 $\pm$ 0.78. The correlation between this ration and disease severity was 0.019.

CONCLUSION:

The results showed that CD4/CD8 ratio has correlation with disease severity in type A hemophilia patients, however there was no association between this ratio and gender.

Keywords

CD4/CD8 ratio hemophilia disease

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The effect of T helper (Th)/T cytotoxic (Tc) ratio on disease severity in type A hemophilia patients