Non-coding RNA elongated (lncRNAs) have recently attracted as molecules that regulate gene expression of the pluripotent properties (pluripotency) of stem cells. Recently our colleagues examined the role of one of these RNAs called SOX2OT in esophageal squamous cell carcinoma, and found a concomitant increase in its expression with some regulatory genes of cell proliferation. In the present study, using the design of suitable primers from SOX2OT gene, we investigated the effect of siRNA on expression of SOX2OT.
KapranovP. et al., RNA maps reveal new RNA classes and a possible function for pervasive transcription, Science316 (2007), 1484–1488.
2.
GuttmanM. et al., Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs, Nature Biotechnology28 (2010), 503.
3.
de KoningA.J.GuW.CastoeT.A.BatzerM.A. and PollockD.D., Repetitive elements may comprise over two-thirds of the human genome, PLoS Genetics7 (2011).
4.
GuptaA.K. and GuptaM., Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications, Biomaterials26 (2005), 3995–4021.
5.
TakahashiK. et al., Induction of pluripotent stem cells from adult human fibroblasts by defined factors, Cell131 (2007), 861–872.
6.
FantesJ.RaggeJ.LynchN.K.McGillS.A.CollinN.I.Howard-PeeblesJ.R.HaywardP.N.VivianC.WilliamsonA.J.van HeyningenK., V 2003 mutations in SOX2 cause anophthalmia, Nature Genetics33, 461–463.
7.
BassA.J. et al., SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas, Nature Genetics41 (2009), 1238–1242.
8.
AmaralP.P. et al., Complex architecture and regulated expression of the SOX2OT locus during vertebrate development, Rna15 (2009), 2013–2027.
9.
HouZ. et al., A long noncoding RNA SOX2OT regulates lung cancer cell proliferation and is a prognostic indicator of poor survival, The International Journal of Biochemistry & Cell Biology53 (2014), 380–388.
10.
ShahryariA. et al., Two novel splice variants of SOX2OT, SOX2OT-S1, and SOX2OT-S2 are coupregulated with SOX2 and OCT4 in esophageal squamous cell carcinoma, Stem Cells32 (2014), 126–134.
11.
ShiX.-M. and TengF., Up-regulation of long non-coding RNA SOX2OT promotes hepatocellular carcinoma cell metastasis and correlates with poor prognosis, International Journal of Clinical and Experimental Pathology8 (2015), 4008.
12.
ZhangY.YangR.LianJ. and XuH., LncRNA SOX2OT overexpression serves as a poor prognostic biomarker in gastric cancer, American Journal of Translational Research8 (2016), 5035.
13.
JaziM.S.SamaeiN.M.GhaneiM.ShadmehrM.B. and MowlaS.J., Overexpression of the non-coding SOX2OT variants 4 and 7 in lung tumors suggests an oncogenic role in lung cancer, Tumor Biology37 (2016), 10329–10338.
14.
IbraheemD.ElaissariA. and FessiH., Gene therapy and DNA delivery systems, International Journal of Pharmaceutics459 (2014), 70–83.
