The hypersensitivity reaction to penicillin is a public health problem. Immunological responses to penicillin and other beta-lactam antibiotics can be classified into immediate and non-immediate responses. The immediate hypersensitivity is mediated by IgE; however, the non-immediate sensitivity is facilitated by other isotypes of antibody or T lymphocytes.
OBJECTIVE:
This research detected the non-IgE antibody value against penicillin in allergic and normal people.
METHODS:
Thirty-eight samples from patients with positive or negative intradermal skin testing results of penicillin allergy were included in this study. The total antibody and IgM levels against penicillin G were defined by in-house ELISA test.
RESULTS:
The results showed a significant ( 0.05) elevation in total immunoglobulin and non-IgM anti-penicillin antibody of sensitive groups; however, the anti-penicillin IgM was significantly greater in non-sensitive peoples.
CONCLUSIONS:
Although the sensitized people to penicillin cannot be certainly detected with the total antibody, specific IgG and IgM value against penicillin, these values are good indicators for prediction of immediate and late response of the immune system to penicillin.
GomezM.B.TorresM.J.MayorgaC. et al., Immediate allergic reactions to betalactams: facts and controversies, Curr Opin Allergy Clin Immunol4 (2004), 261–266.
2.
PichicheroM.E. and ZagurskyR., Penicillin and Cephalosporin allergy, Ann Allergy Asthma Immunol112 (2014), 404–412.
3.
MengX.JenkinsR.F.BerryN.G.MaggsJ.L.FarrellJ.LaneC.S.StachulskiA.V.FrenchN.S.NaisbittD.J.PirmohamedM. et al., Direct evidence for the formation of disaster eoisomeric benzyl penicilloyl haptens from benzyl penicillin and benzyl penicillenic acid in patients, J Pharmacol Exp Ther338 (2011), 841–849.
4.
SinghK.V.KaurJ.VarshneyG.C.RajeM. and SuriC.R., Synthesis and characterization of hapten-protein conjugates for antibody production against small molecules, Bioconjug Chem15(1) (2004), 168–173.
5.
MacyE., Penicillin and Beta-Lactam Allergy: Epidemiology and Diagnosis, Curr Allergy Asthma Rep14(11) (2014), 476.
6.
PadovanE.BauerT.TongioM.M.KalbacherH. and WeltzienH.U., Penicilloyl peptides are recognized as T cell antigenic determinants in penicillin allergy, Eur J Immunol27 (1997), 1303–1307.
7.
BlancaM.RomanoA.TorresM.J.FernandezJ.MayorgaC.RodriguezJ.DemolyP.BousquetP.J.MerkH.F.SanzM.L.OttH. and Atanaskovic-MarkovicM., Update on the evaluation of hypersensitivity reactions to betalactams, Allergy64 (2009), 183–193.
8.
MirakianR.LeechS.C.KrishnaM.T.RichterA.G.HuberP.A.FarooqueS.KhanN.PirmohamedM.ClarkA.T. and NasserS.M., Management of allergy to penicillins and other beta-lactams, ClinExp Allergy45(2) (2015), 300–327.
9.
MayorgaC.SanzM.L.GamboaP.M.GarciaB.E.CaballeroM.T.GarciaJ.M.LabradorM.LahozC.Longo AresoN.Lopez HoyosM.Martinez QuesadaJ. and MonteseirinF.J., In vitro diagnosis of immediate allergic reactions to drugs: an update, J Investig Allergol Clin Immunol20(2) (2010), 103–109.
10.
Co MinhH.B.BousquetP.J.FontaineC.KvedarieneV. and DemolyP., Systemic reactions during skin tests with betalactams: a risk factor analysis, J Allergy ClinImmunol117 (2006), 466–468.
11.
MeraK.NagaiM.BrockJ.W.FujiwaraY.MurataT.MaruyamaT.BaynesJ.W.OtagiriM. and NagaiR., Glutaraldehyde is an effective cross-linker for production of antibodies against advanced glycation end-products, J Immunol Methods20(334) (2008), 82–90.
12.
LaemmliK., Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature227 (1970), 680–685.
13.
CavalieriS.J., Manual of Antimicrobial Susceptibility Testing. Chapter 4: Disk Diffusion Testing, American Society for Microbiology ISBN: 1555813496, 2009, 39–52.
14.
InceogluaB.LangobJ.RabinovichaA.WhetstoneaP. and HammockB.D., The neutralizing effect of a polyclonal antibody raised against the N-terminal eighteen-amino acid residues of birtoxin towards the whole venom of Parabuthus transvaalicus, Toxicon47 (2006), 144–149.
15.
EppM., Serological procedure for the detection of antibodies to penicillin, Science130(3387) (1959),1472.
KhoobdelM.NayeriFasaeiB.ZahraeiSalehiT.KhosraviM.KoochakzadehA.TaheriM.MasihipourB.MotedayenM.H. and AkbariS., The production of anti-idiotype antivenom against Mesobuthus Eupeus (Scorpionida: Buthidae) venom in rabbits, Toxicon76 (2013), 44–49.
18.
LegendreD.P.MuznyC.A.MarshallG.D. and SwiatloE., Antibiotic hypersensitivity reactions and approaches to desensitization, Clin Infect Dis58(8) (2014), 1140–1148.
19.
SudlowG.BirkettD.J. and WadeD.N., The characterization of two specific drug binding sites on human serum albumin, Mol Pharmacol11(6) (1975), 824–832.
20.
CabauN.LevyF.M.ZivyD.BarrierJ. and RouxF., Evolution of titre of serum IgG in newborn, Neonatology25 (1974), 194–207.
21.
KlausM. and FellnerM.J., Penicilloyl-specific serum antibodies in man, Journal of Gerontology28(3) (1973), 312–316.
OettgenH.C.MartinT.R.Wynshaw-BorisA.DengC.DrazenJ.M. and LederP., Active anaphylaxis in IgE-deficient mice, Nature370 (1994), 367–370.
24.
MehlhopP.D.Van De RijnM.GoldbergA.B. et al., Allergen-induced bronchial hyper reactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma, Proc Natl Acad Sci USA94 (1997), 1344–1349.
25.
TorresM.J.GonzalezF.J.MayorgaC. et al., IgG and IgE antibodies in subjects allergic to penicillins recognize different parts of the penicillin molecule, Int Arch Allergy Immunol113 (1997), 342–344.
26.
TorresM.J.MayorgaC.PamiesR. et al., Immunologic response to different determinants of benzylpenicillin, amoxicillin, and ampicillin, Comparison Between Urticaria and Anaphylactic Shock, Allergy54 (1999), 936–943.
27.
QiaoH.L.GaoN.JiaL.J.YangJ. and TianX., Specific IgG antibodies in sera in patients with penicillin allergy, Clin Exp Med9 (2009), 105–111.
28.
ChristieG.ColemanJ.W.NewbyS.Mc Diarmaid-GordonA.HampsonJ.P.BreckenridgeA.M. and ParkB.K., A survey of the prevalence of penicillin-specific IgG, IgM and IgE antibodies detected by ELISA and defined by hapten inhibition, in patients with suspected penicillin allergy and in healthy volunteers, Br J Clin Pharmacol25(3) (1988), 381–386.
29.
LeeD.DewdneyJ.M.EdwardsR.G.NeftelK.A. and WaltiM., Measurement of specific IgG antibody levels in serum of patients on regimes comprising high total dose beta-lactam therapy, Int Arch Allergy Appl Immunol79(4) (1986), 344–348.
30.
ChandraR.K.JoglekarS.A. and TomasE., Penicillin allergy: anti-penicillin IgE antibodies and immediate hypersensitivity skin reactions employing major and minor determinants of penicillin, Archives of Disease in Childhood55 (1980), 857–860.
31.
KukkonenA.K.SavilahtiE.M.HaahtelaT.SavilahtiE. and KuitunenM., Ovalbumin-specific immunoglobulins A and G levels at age 2 years are associated with the occurrence of atopic disorders, Clin Exp Allergy41 (2011), 1414–1421.
32.
SimanI.L.de AquinoL.M.YnoueL.H.MirandaJ.S.PajuabaA.C.Cunha-JuniorJ.P.SilvaD.A. and TaketomiE.A., Allergen-specific IgG antibodies purified from mite-allergic patients sera block the IgE recognition of Dermatophagoides pteronyssinus antigens: an in vitro study, Clin Dev Immunol657424 (2013), doi: 10.1155/2013/657424.
33.
MeulenbroekL.A.de JongR.J.den HartogJagerC.F.MonsuurH.N.WoutersD.NautaA.J.KnippelsL.M.van NeervenR.J.RuiterB.LeusenJ.H.HackC.E.Bruijnzeel-KoomenC.A.KnulstA.C.GarssenJ. and van HoffenE., IgG antibodies in food allergy influence allergen-antibody complex formation and binding to B cells: a role for complement receptors, J Immunol191(7) (2013), 3526–3533. doi: 10.4049/jimmunol.1202398.
34.
MontanezM.I.ArizaA.MayorgaC.FernandezT.D. and TorresM.J., Cross-reactivity in betalactam allergy: Alternative treatments, Curr Treat Options Allergy2 (2015), 141–154.
35.
AmaliM.O.JenkinsR.E.MengX.FaulknerL.WhitakerP.PeckhamD.ParkB.K. and NaisbittD.J., Assessment of anti piperacillin IgG binding to structurally related drug protein adducts, Chem Res Toxicol (2017), doi: 10.1021/acs.chemrestox.7b00291.
