Abstract
Mutation of p53 gene is known to be one of the most common specific gene change in human cancers, although the role of the gene alternation on malignant transformation is still controversial. In this study, we report the immunolocalization of p53 protein, as well as PCNA and MIB-1, in inverted papilloma (IP) associated with squamous cell carcinoma. p53 positive nuclei were absent in the normal mucosa, basally localized in benign portion of IP and diffusely observed in the squamous cell carcinoma (SCC). Not only the number of positive nuclei, but also the change of distribution correlate to those of PCNA and MIB-1. The results suggest the important role of mutant p53 gene on malignant transformation of IP.
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