Claussnitzer et al. claimed in previous work that a regulatory element within the first intron of FTO affects IRX3 and IRX5 expression during early adipogenesis. We present here a formalization of that claim, stating that all things of class “early human adipogenesis” that are in the context of a thing of class “regulatory element within the first intron of FTO” generally have a relation of type “affects” to a thing of class “expression of genes IRX3 and IRX5” in the same context.
Claussnitzer et al. [1] state that “The rs1421085 T-to-C single-nucleotide variant disrupts a conserved motif for the ARID5B repressor, which leads to derepression of a potent preadipocyte enhancer and a doubling of IRX3 and IRX5 expression during early adipocyte differentiation.”. We present here a formalization of the main scientific claim from this quote by using a semantic template called the super-pattern [2].
In the context class we use a new minted class “early human adipogenesis” that is a subclass of “adipogenesis” (Q2824461) from Wikidata. In the subject class, we use a new minted class “regulatory element within the first intron of FTO” that is related to the class “FTO” (Q14912501) and “intron” (Q207551) from Wikidata. In the object class we minted a new class “expression of genes IRX3 and IRX5” that is a subclass of “gene expression” (Q26972) from Wikidata and is related to the class “IRX5” (Q18035174) and “IRX3” (Q18046058) from Wikidata.
RDF Code
This is our formalization as a nanopublication in TriG format:
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The following nanopublications introduce the newly minted classes in TriG format.
This is the class definition of “early human adipogenesis”:
