A study of hemorheological behaviour for patients with Alzheimer's disease at the early stages

Abstract

To evaluate the change of hemorheological indexes for patients with Alzheimer's disease (AD) at the early stages and to discuss effects of these changes on AD, high shear value of whole blood viscosity (η_bh), reduced high shear value of whole blood viscosity (rη_bh), low shear value of whole blood viscosity (η_bl), reduced low shear, value of whole blood viscosity (rη_bl), KT value of whole blood viscosity, hematocrit (HCT) and blood plasma viscosity (η_P) were measured in 31 patients with probable AD at the early stages and 33 age‐matched healthy subjects. There were significant differences of all hemorheological indexes between AD group and control group except HCT. Step discriminant analysis revealed 81.25% of overall group‐classified accuracy in a hemorheological discriminant function consisting of η_bl, rη_bl, rη_bh and HCT. Significant difference of hemorheological indexes existed between AD and age‐matched healthy control subjects. The results showed that measurement of hemorheological indexes could be used as one of reference standards of diagnosis in AD.