Arterial hypertension decreases fibrinogen molecules contribution to the inter‐red cells connections in stroke patients

Abstract

In a group of 36 patients with acute ischemic stroke, the study of influence of arterial hypertension on the red cells and fibrinogen interaction was carried out by the aspect of fibrinogen molecules contribution to this phenomenon, respecting the role of other plasma biochemical factors. Patients were divided into two clinical groups: with and without arterial hypertension. In the blood samples with stable haematocrit ratio the following rheological properties were estimated: plasma viscosity, yield shear stress (YSS), fibrinogen level and parameter R (the difference between twice measurements of fibrinogen concentration). There were also measured the levels of albumin, IgG, IgA, IgM, cholesterol, HDL and LDL. The value of parameter R in patients with arterial hypertension was lower than the group without accompanying disease (statistical significance was indicated for 80% and 60% of plasma dilution). The first group of patients was also characterized by significant increase of IgA level (in comparison with the control group), whereas the red cells and fibrinogen interaction measured as a value of YSS was similar in both analyzed clinical groups. This study indicated a specific character some of hemorehological changes in relation to a certain vascular pathology.