The external perfusion software (VueBox™) for contrast-enhanced ultrasound (CEUS), enables the quantitative analysis of micro-vascularization within non-cystic lesions in terms of characterization and detection. This review summarizes our work about parathyroid gland, thyroid gland, liver, prostate and other tissues as well as original studies in the use of parametric perfusion imaging. Useful perfusion parameters are introduced.
SeitzK, StrobelD. A Milestone: Approval of CEUS for Diagnostic Liver Imaging in Adults and Children in the USA. Ultraschall in der Medizin (Stuttgart, Germany : 1980). 2016;37(3):229–32.
2.
DietrichCF, NolsøeCP, BarrRG, et al.Guidelines and Good Clinical Practice Recommendations for Contrast-Enhanced Ultrasound (CEUS) in the Liver-Update 2020 WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS. Ultrasound in Medicine & Biology. 2020;46(10):2579–604.
3.
PiscagliaF, NolsoeC, DietrichCF, et al.The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): update 2011 on non-hepatic applications. Ultraschall in der Medizin (Stuttgart, Germany : 1980). 2012;33(1):33–59.
4.
AlbrechtT, BlomleyM, BolondiL, et al.Guidelines for the use of contrast agents in ultrasound. January 2004. Ultraschall in der Medizin (Stuttgart, Germany : 1980). 2004;25(4):249–56.
5.
JungEM, StroszczynskiC, JungF. Contrast enhanced ultrasonography (CEUS) to detect abdominal microcirculatory disorders in severe cases of COVID-19 infection: First experience. Clin Hemorheol Microcirc. 2020;74(4):353–61.
6.
KlotzLV, IngrischM, EichhornME, et al.Monitoring parotid gland tumors with a new perfusion software for contrast-enhanced ultrasound. Clin Hemorheol Microcirc. 2014;58(1):261–9.
7.
ClevertDA, D’AnastasiM, JungEM. Contrast-enhanced ultrasound and microcirculation: efficiency through dynamics–current developments. Clin Hemorheol Microcirc. 2013;53(1-2):171–86.
8.
XuHX. Contrast-enhanced ultrasound in the biliary system: Potential uses and indications. World J Radiol. 2009;1(1):37–44.
9.
HuW, DongY, ZhangX, ZhangH, LiF, BaiM. The clinical value of Arrival-time Parametric Imaging using contrast-enhanced ultrasonography in differentiating benign and malignant breast lesions. Clin Hemorheol Microcirc. 2020;75(3):369–82.
10.
RennertJ, WiesingerI, BeyerLP, et al.Color coded perfusion analysis and microcirculation imaging with contrast enhanced ultrasound (CEUS) for post-interventional success control following thermal ablative techniques of primary and secondary liver malignancies. Clin Hemorheol Microcirc. 2019;73(1):73–83.
11.
GreisC. Technical aspects of contrast-enhanced ultrasound (CEUS) examinations: tips and tricks. Clinical hemorheology and microcirculation. 2014;58(1):89–95.
12.
UggowitzerMM, GotschuliG, ReiterH, PetekB. [Contrast-enhanced sonography of the liver]. Der Radiologe. 2005;45(1):24–33.
13.
PiscagliaF, BolondiL. The safety of Sonovue in abdominal applications: retrospective analysis of 8 investigations. Ultrasound in Medicine & Biology. 2006;32(9):1369–75.
14.
WildnerD, PfeiferL, GoertzRS, et al.Dynamic contrast-enhanced ultrasound (DCE-US) for the characterization of hepatocellular carcinoma and cholangiocellular carcinoma. Ultraschall in der Medizin. 2014;35(6):522–7.
15.
TranquartF, MercierL, FrinkingP, GaudE, ArditiM. Perfusion quantification in contrast-enhanced ultrasound (CEUS)–ready for research projects and routine clinical use. Ultraschall in der Medizin. 2012;33(Suppl 1):S31–8.
16.
BulvikBE, RozenblumN, GourevichS, et al.Irreversible Electroporation versus Radiofrequency Ablation: A Comparison of Local and Systemic Effects in a Small-Animal Model. Radiology. 2016;280(2):413–24.
17.
WiesingerI, WiggermannP, ZausigN, et al. Percutaneous Treatment ofMalignant Liver Lesions: Evaluation of Success Using Contrast- Enhanced Ultrasound (CEUS) and Perfusion Software. Ultraschall in der Medizin. 2017.
18.
MaxeinerA, FischerT, SchwabeJ, et al.Contrast-Enhanced Ultrasound (CEUS) and Quantitative Perfusion Analysis in Patients with Suspicion for Prostate Cancer. Ultraschall in der Medizin. 2019;40(3):340–8.
19.
JungEM, WiggermannP, GreisC, et al.First results of endocavity evaluation of the microvascularization of malignant prostate tumors using contrast enhanced ultrasound (CEUS) including perfusion analysis: first results. Clin Hemorheol Microcirc. 2012;52(2-4):167–77.
20.
MeiJJ, ZhaoYX, JiangY, WangJ, YuJS. Association Between Contrast-Enhanced Ultrasound Indicators and Prostate Cancer Biochemical Recurrence After Treatment. Cancer Manag Res. 2020;12:4959–68.
21.
BacchettaF, MartinsM, RegusciS, et al.The utility of intraoperative contrast-enhanced ultrasound in detecting residual disease after focal HIFU for localized prostate cancer. Urol Oncol. 2020;38(11):846 e1–e7.
22.
MuellerS, GosauM, WendlCM, et al.Postoperative evaluation of microvascularization in mandibular reconstructions with microvascular flaps - first results with a new perfusion software for contrast-enhanced sonography (CEUS). Clin Hemorheol Microcirc. 2012;52(2-4):187–96.
23.
GeisS, PrantlL, GehmertS, et al.TTP (time to PEAK) and RBV (regional blood volume) as valuable parameters to detect early flap failure. Clin Hemorheol Microcirc. 2011;48(1):81–94.
24.
GeisS, PrantlL, MuellerS, GosauM, LambyP, JungEM. Quantitative assessment of bone microvascularization after osteocutaneous flap transplantation using contrast-enhanced ultrasound (CEUS). Ultraschall in der Medizin. 2013;34(3):272–9.
25.
Platz Batista da SilvaN, JungEM, JungF, SchlittHJ, HornungM. VueBox® perfusion analysis of contrast-enhanced ultrasound (CEUS) examinations in patients with primary hyperparathyroidism for preoperative detection of parathyroid gland adenoma. Clin Hemorheol Microcirc. 2018;70(4):423–31.
26.
Parra RamírezP, Santiago HernandoA, Barquiel AlcaláB, Martín Rojas-MarcosP, Lisbona CatalánA, Álvarez EscoláC. Potential Utility of Contrast-Enhanced Ultrasound in the Preoperative Evaluation of Primary Hyperparathyroidism. Journal of ultrasound in medicine: official journal of the American Institute of Ultrasound in Medicine. 2019;38(10):2565–71.
27.
WendlCM, JankeM, JungW, StroszczysnskiC, JungEM. Contrast-enhanced ultrasound with perfusion analysis for the identification of malignant and benign tumours of the thyroid gland. Clin Hemorheol Microcirc. 2015;63(2):113–21.
28.
WiesingerI, KroissE, ZausigN, et al.Analysis of arterial dynamic micro-vascularization with contrast-enhanced ultrasound (CEUS) in thyroid lesions using external perfusion software: First results. Clin Hemorheol Microcirc. 2016;64(4):747–55.
29.
SchlederS, JankeM, AghaA, et al.Preoperative differentiation of thyroid adenomas and thyroid carcinomas using high resolution contrast-enhanced ultrasound (CEUS). Clin Hemorheol Microcirc. 2015;61(1):13–22.
30.
ZhangJ, ZhangX, MengY, ChenY. Contrast-enhanced ultrasound for the differential diagnosis of thyroid nodules: An updated meta-analysis with comprehensive heterogeneity analysis. PloS One. 2020;15(4):e0231775.
31.
SchwarzeV, MarschnerC, Negrao De FigueiredoG, IngrischM, RübenthalerJ, ClevertDA. Single-center study: dynamic contrast-enhanced ultrasound in the diagnostic assessment of carotid body tumors. Quant Imaging Med Surg. 2020;10(9):1739–47.
32.
NylundK, SævikF, LehS, PfefferF, HauskenT, GiljaOH. Interobserver Analysis of CEUS-Derived Perfusion in Fibrotic and Inflammatory Crohn’s Disease. Ultraschall in der Medizin. 2019;40(1):76–84.
33.
HarroisA, GrillotN, FigueiredoS, DuranteauJ. Acute kidney injury is associated with a decrease in cortical renal perfusion during septic shock. Critical Care. 2018;22(1):161.
34.
VitaliF, PfeiferL, JansonC, et al.Quantitative perfusion analysis in pancreatic contrast enhanced ultrasound (DCE-US): a promising tool for the differentiation between autoimmune pancreatitis and pancreatic cancer. Zeitschrift fur Gastroenterologie. 2015;53(10):1175–81.
35.
LengX, HuangG, MaF, YaoL. Regional Contrast-Enhanced Ultrasonography (CEUS) Characteristics of Breast Cancer and Correlation with Microvessel Density (MVD). Med Sci Monit. 2017;23:3428–36.
36.
LassauN, BonastreJ, KindM, et al.Validation of dynamic contrast-enhanced ultrasound in predicting outcomes of antiangiogenic therapy for solid tumors: the French multicenter support for innovative and expensive techniques study. Investigative Radiology. 2014;49(12):794–800.
37.
LassauN, ChamiL, KoscielnyS, et al.Quantitative functional imaging by dynamic contrast enhanced ultrasonography (DCE-US) in GIST patients treated with masatinib Contrast-Enhanced Ultrasound (CEUS) and Quantitative Perfusion Analysis in Patients with Suspicion for Prostate Cancer. Invest New Drugs. 2012;30(2):765–71.
38.
LambyP, PrantlL, Kruger-GengeA, FrankeRP, JungEM, JungF. Influence of Ultrasound Microbubbles on kidney oxygen tension. Clin Hemorheol Microcirc. 2017;67(3-4):211–4.
39.
LambyP, JungF, GrafS, et al.Effect of iodinated contrast media on renal perfusion: A randomized comparison study in pigs using quantitative contrast-enhanced ultrasound (CEUS). Scientific reports. 2017;7(1):13125.
40.
AronsonS, ThistlethwaiteRJ, WalkerR, FeinsteinSB, RoizenMF. Safety and feasibility of renal blood flow determination during kidney transplant surgery with perfusion ultrasonography. Anesth Analg. 1995;80(2):353–9.
41.
FrankeRP, FuhrmannR, HieblB, JungF. Influence of various radiographic contrast media on the buckling of endothelial cells. Microvasc Res. 2008;76(2):110–3.
42.
BachR, JungF, SchellerB, et al.Influence of a non-ionic radiography contrast medium on the microcirculation. Acta Radiologica. 1996;37(2):214–7.
43.
ReinhartWH, PleischB, HarrisLG, LütolfM. Influence of contrast media (iopromide, ioxaglate, gadolinium-DOTA) on blood viscosity, erythrocyte morphology and platelet function. Clin Hemorheol Microcirc. 2005;32(3):227–39.
44.
LambyP, MinkowA, HandtS, et al.Histological and SEM Assessment of Blood Stasis in Kidney Blood Vessels after Repeated Intra-Arterial Application of Radiographic Contrast Media. Life (Basel). 2020;10(9):167.
