Abstract
Erythrocyte membrane lipids, ATPase activities, blood cell parameters and hemorheological changes were measured in 51 patients with acute cerebral infarction, 12 patients with arteriosclerosis and 51 normal controls. A decrease in erythrocyte deformability, ATPase activities and an increase in CHO/PL ratio and viscosity at high shear rate were observed in stroke patients in which a significant difference was found compared with that of the control group. Multivariate regression analysis indicated that membrane lipids, ATPase activities, CHO/PL ratio viscosity at high shear rate had linear correlation with erythrocyte deformability. The coefficient of multiple correlation was 0.8937.
These findings suggested that the erythrocyte membrane lipid composition and ATPase activities change significantly in stroke patients. These may be the cause of hemorheological disturbance. These changes existed before the occurrence of the stroke. So it is important to treat the circulation disorder in arteriosclerosis patients to prevent the cerebral infarction. The adoption of treatment with drugs for improving microcirculation and ion transport may be of benefit in the recovery from a stroke. We concluded from our study that CHO/PL could be a feature of arteriosclerosis or strokes, and ATPase activities may serve as an early indication of the patient's state.
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