Abstract
The effect of a commercially available human immunoglobulin G—Sandoglobulin R—on the rheological properties was quantitatively examined in 51 pregnant women with a history of two or more spontaneous abortions. The in vivo effects were assessed during 5 courses of treatment with 150 g, 102 g and 66 g immunoglobulin, respectively.
We could not demonstrate a significant effect after IVIG on erythrocyte aggregation, plasma fibrinogen and hematocrit. The dose dependent changes in plasma viscosity that occur after IVIG therapy are compensated by hemodilution.
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