Abstract
Erythrocytes (RBC) from patients with sickle cell anemia are abnormally adherent to vascular endothelium, and this is believed to participate in development of microvascular occlusion. Various studies of this phenomenon have disagreed regarding mechanism of adhesivity and identity of the most adherent RBC subpopulation. The data can be reconciled by recognizing that several factors may influence adhesivity and lead to variable participation by multiple mechanisms.
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