Abstract
Cytokine produce important effects on polymorphonuclear (PMN) functions. We have studied PMN functions in patients with acute inflammatory syndrome with endogenous production of cytokines due to myocardial infarction (MI) at D1 and D3 and in patients suffering from neoplasia submitted to different in vivo cytokines administration: Interleukine 2 (IL-2), Interferon gamma (IFN-G), association IL-2/IFN-G, Granulocyte-colony stimulating factor (G-CSF) before (D0) and at the end of treatment (D36).
In MI, leukocyte count increased on the first day and decreased at 03 certainly due to plugging and local destruction. Leukocyte activation occured at 01 and was more pronounced at D3. The in vivo administration of cytokines had contradictory effects:
– IL-2 had a significant inhibitory effect on directed chemotaxis at the end of treatment (D36), while the other functions were not modified.
– INF-G had no effect.
– This inhibitory effect of IL-2 was not observed when IFN-G was administrated together with IL-2.
– G-CSF induced the most important activation of PMN.
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