Pharmacological aspects of erythrocyte aggregation,effect of high doses of troxerutine

Abstract

Rheological factors appear to be of a great importance in Venous Insufficiency. They are related to several biological disorders, as haemoconcentration and imbalance of plasma proteins, and are markedly increased in varicose and/or altered veins. Erythrocyte hyperaggregation is thought to be the most interesting physiopathological disturbance, related, in such patients, to alteration of thyxotropic properties of the blood, as well as structural defects of low flow forming red blood cells aggregates. Troxerutine, a potent drug on vessel wall, exhibits in patients a direct action on red cell aggregation, particularly marked at high doses. The beneficial effects of troxerutine should therefore be exerted via actions on vessel wall and red blood cells.