Abstract
The effect of sialic acid of erythrocytes on the cellular aggregation and deformability was quantitatively examined. Desialylated red blood cells were obtained after incubation with neuraminidase at different concentrations. The electrophoretic mobility was controlled. Erythrocyte aggregation was measured via ultrasound backscattering on erythrocytes resuspended In autoloqous plasma. Red blood cell deformability was studied on dilute suspensions In phosphate buffer by the Initial flow rate filtration method and the cell transit time analysis. For desialylated red blood cells In suspension. Aggregation is increased due to the reduction of the electrostatic repulsive force among erythrocytes. An increase of the cellular transit time is found. A reason which could explain this phenomenon is the role of the cell membrane-pore wall sieves Interactions.
Get full access to this article
View all access options for this article.