Effect of beta-blocking agents on hemorheological properties

Abstract

Abnormal rheological properties of red cells are important in a wide range of microvascular diseases. A beneficial effect of beta-blocking drugs has been noted in the secondary prevention of myocardial infarction. We therefore investigated the influence of these drugs on red cell rheology. Erythrocyte filtrability was significantly increased after incubation with Metoprolol, there was no effect, however, after incubation with Propranolol or Timolol. The exact mechanism of this effect is still unknown. Differences regarding cardioselectivity do not seem to be involved. Lipophilic agents, however, induce changes within the erythrocyte membrane leading to a constant cell volume.