Abstract
The effect of some plasma expanders (dextran 40, polygeline, succinyl-gelatin) currently used for normovolernic hemodilution (NHD) and of isotonic saline on erythrocyte deformability was tested by a whole blood filtration technique in vitro and ex vivo after NHD. Dextran 40 resulted able to improve erythrocyte filtrability ex vivo but not in vitro. Gelatine derivatives did not change ex vivo and worsened in vitro erythrocyte filtration rate. Hyperosmolarity was a major determinant of the negative influence exerted by plasma expanders on erythrocyte flexibility in vitro.
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