Abstract
The effect of patient pathology on plasma production performance during plasma exchange was studied operating a continuous flow centrifugal separator (IBM 2997) in a standardized way. The disease categories were TTP, Neuro-Muscular Disorders, Hyper-Viscosity Syndrome and others (which included Hemolytic Amemia and Goodpastures Syndrome). Plasma production performance was considered from two points of view: Plasma production efficiency and residual platelet count in the separated plasma. Analysis of 254 procedures showed plasma separation efficiency is high – greater than 80% – and not strongly affected by patient pathology. Platelet clearance from separated plasma is dependent on patient pathology and was found to range from 60% to 90%.
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