Abstract
The relative effects of three vinca alkaloids on the erythrocyte surface were assessed by evaluating erythrocyte aggregation. The time required for aggregation and the rate of sedimentation of formed aggregates was quantitated in systems utilizing Dextran, polybrene, and an antibody as the aggregation inducers. Vinca alkaloid inhibition of erythrocyte aggregation was demonstrated which appears to be concentration dependent. Vinblastine was more inhibitory than Vindesine or Vincristine. Scanning electron microscopy suggests that decreased deformability is a factor in vinca alkaloid inhibition of erythrocyte aggregation.
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