The proper phase of coagulation its physical differentiation by resonance-thrombography and thrombelastography

Abstract

Coagulation of blood is comparable to building a house. The plasmatic (fluid) phase of coagulation in the example of building includes any preparation until laying the foundation stone. Thereafter the proper phase of coagulation is the erection of the building itself. Thrombelastography and Resonance-Thrombography are the methods to measure the start and progress in raising a clot structure with elastic fibrin molecules and their condensation by platelets. Their parameter of measurement is clot elasticity, which in a wide range allows to differentiate the course of blood coagulation for diagnosis of hemorrhagic diseases as well as for the effect of clot-controlling therapeutical and experimental measures. In the Thrombelastogram (TEG) fibrin elasticity and condensating effect of platelets cannot be differentiated, a fact which in a clinical laboratory for screening of hemorrhagic disorders represents some methodical limitation. Therefore the Resonace-Thrombography was developed, which with a simulation of flow. with a permanent “natural” strain on the growing fibrin structure by minimal orbital movement and with the utilization of a resonance effect for high sensitivity in measuring elasticity module is able to give additional informations. Especially platelet dysfunctions, dysfibrinogenemias as in liver diseases and in disseminated intravascular clotting as well as combined defects of the coagulation system including fibrinolysis may in the sense of screening by differentiation early and simply be diagnosed in the Resonance-Thrombogram (RTG).